Abstract: The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.
Type:
Grant
Filed:
June 28, 2022
Date of Patent:
January 23, 2024
Assignees:
The United States of America, as Represented by the Secretary, Dept. of Health and Human Services, Florida Stte University Research Foundation, Inc., The Trustees of the University of Pensylvania
Inventors:
Hengli Tang, Emily M. Lee, Wei Zheng, Ruili Huang, Miao Xu, Wenwei Huang, Khalida Shamim, Guoli Ming, Hongjun Song
Abstract: The invention provides compositions and methods for protecting organs, such as lungs, from injury associated with transplantation. Specifically, the invention relates to secoisolaricirecinol diglucoside (SDG), including natural SDG, synthetic SDG (LGM2605), (S,S)-SDG, (R,R)-SDG and mixtures thereof, as well as related molecules, for protecting lungs from injury, such as ischemia/reperfusion injury, associated with transplantation.
Type:
Application
Filed:
June 5, 2017
Publication date:
May 9, 2019
Applicant:
THE TRUSTEES OF THE UNIVERSITY OF PENSYLVANIA
Inventors:
Melpo CHRISTOFIDOU-SOLOMIDOU, EDWARD CANTU
Abstract: The present invention relates to the use of non-pathogenic antibodies to deliver biologically-active proteins to specific cellular and sub-cellular sites. The invention also relates to the use of non-pathogenic antibodies to deliver biologically-active, non-protein molecules to specific cellular and sub-cellular sites.
Type:
Application
Filed:
January 9, 2008
Publication date:
August 18, 2011
Applicants:
Trustees of The University of Pensylvania, Keio University
Inventors:
John R. Stanley, Donald L. Siegel, Amagai Masayuki