Patents Assigned to The United States as represented by the Secretary of the Department of Health and Human Services
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Patent number: 11273130Abstract: The present disclosure provides a method for delivering a neuroprotective polypeptide to at least a portion of a central nervous system (CNS) of a subject.Type: GrantFiled: October 20, 2017Date of Patent: March 15, 2022Assignees: The United States, as represented by the Secretary Department of Health and Human Services, Peptron, Inc.Inventors: Dong Seok Kim, Hee Kyung Kim, Nigel H. Greig
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Patent number: 9616139Abstract: The disclosure provides directly conjugated polysaccharide vaccine molecules and methods related thereto.Type: GrantFiled: July 11, 2012Date of Patent: April 11, 2017Assignees: The General Hospital Corporation, The United States, as represented by the secretary, Department of Health and Human Services, International Centre for Diarrhoeal Disease Research, BangladeshInventors: Edward T. Ryan, Pavol Kovac, Firdausi Qadri, Peng Xu, Stephen B. Calderwood, Willie Frank Vann, Dwight Christopher Peterson
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Patent number: 9018011Abstract: Regulatory elements, specifically insulators and transgene constructs containing insulator nucleic acid sequences, are disclosed herein. Methods of using insulators and transgene constructs including insulators to inhibit, delay, or prevent gene silencing are also disclosed herein.Type: GrantFiled: February 15, 2008Date of Patent: April 28, 2015Assignee: The United States as represented by the Secretary of the Department of Health and Human ServicesInventors: Jung-Hyun Kim, Vladimir L. Larionov, Tom Ebersole
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Publication number: 20140288022Abstract: Functionalized chondroitin sulfate, cross-linked polymer matrices comprising functionalized chondroitin sulfate, and methods of making and using the same are provided. Such polymer matrices may be used for tissue engineering, reconstructing cartilage, and the like. Kits are also provided for detection of cartilage degrading enzymes.Type: ApplicationFiled: March 17, 2014Publication date: September 25, 2014Applicants: The Johns Hopkins University, The United States, as represented by the Secretary Department of Health & Human Services, University of Maryland, BaltimoreInventors: Jennifer H. Elisseeff, Rocky S. Tuan, Qiang Li, Dongan Wang, Ronald Paul Silverman
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Publication number: 20140221234Abstract: A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on the outcome of the supervised pattern recognition method, choosing multiple data points from the data, wherein the choice is based on the relative ranking of the individual data points, and using the multiple data points to determine if an unknown set of experimental data indicates a diseased condition, a predilection for a diseased condition, or a prognosis about a diseased condition.Type: ApplicationFiled: December 30, 2013Publication date: August 7, 2014Applicant: Government of the United States Represented by the Secretary, Department of Health and Human ServiceInventors: Javed Khan, Markus Ringner, Carsten Peterson, Paul Meltzer
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Publication number: 20110081377Abstract: The present invention generally features methods for the mucosal delivery of immunogenic compositions and methods for treating or preventing diseases featuring such immunogenic compositions. In particular embodiments, the immunogenic compositions are genetic vaccines formulated as aerosols.Type: ApplicationFiled: September 21, 2010Publication date: April 7, 2011Applicant: The United States, as represented by the Secretary Department of Health and Human ServicesInventors: Mario Roederer, Srinivas Rao, Gary J. Nabel, Charla A. Andrews
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Patent number: 7314625Abstract: The invention provides chimeric proteins comprising a non-toxic Pseudomonas exotoxin A sequence and a Type IV pilin loop sequence, wherein the Type IV loop sequence is inserted within the non-toxic Pseudomonas exotoxin A. The invention also provides polynucleotides encoding the chimeric proteins, and compositions comprising the polynucleotides or the chimeric proteins. The invention also provides methods for using the chimeric proteins, polynucleotides and compositions of the invention.Type: GrantFiled: December 20, 2001Date of Patent: January 1, 2008Assignee: The United States as represented by the Secretary of the Department of Health and Human ServicesInventor: David J. FitzGerald
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Patent number: 5677274Abstract: The present invention provides a nucleic acid encoding a fusion protein comprising a nucleotide sequence encoding the anthrax protective antigen (PA) binding domain of the native anthrax lethal factor (LF) protein and a nucleotide sequence encoding an activity inducing domain of a second protein. Also provided is a nucleic acid encoding a fusion protein comprising a nucleotide sequence encoding the translocation domain and LF binding domain of the native anthrax PA protein and a nucleotide sequence encoding a ligand domain which specifically binds a cellular target. Proteins encoded by the nucleic acid of the invention, vectors comprising the nucleic acids and hosts capable of expressing the protein encoded by the nucleic acids are also provided. A composition comprising the PA binding domain of the native LF protein chemically attached to a non-LF activity inducing moiety is further provided. A method for delivering an activity to a cell is provided.Type: GrantFiled: June 25, 1993Date of Patent: October 14, 1997Assignee: The Government of the United States as represented by the Secretary of the Department of Health and Human ServicesInventors: Stephen H. Leppla, Kurt R. Klimpel, Naveen Arora, Yogendra Singh, Peter J. Nichols
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Patent number: 5418160Abstract: The present invention relates to a fat cell specific rat .beta.-adrenergic receptor that mediates lipolysis in rats. The invention further relates to cloned cells which code for the specific .beta.-adrenergic receptor that mediates lipolysis. Another aspect of the present invention relates to a diagnostic test method for determining decreased levels of fat cell .beta.-adrenergic receptors that mediate lipotysis in order to diagnosis obesity caused by less active lipolysis.Type: GrantFiled: November 1, 1991Date of Patent: May 23, 1995Assignee: The United States as represented by the Secretary of the Department of Health and Human ServicesInventors: J. Craig Venter, Claire M. Fraser, Jean-Paul Giacobino
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Patent number: 4514506Abstract: The invention comprises a method for the purification of a human lung tumor-associated antigen (hLTAA) specific to human lung tumors of diverse histological characteristics; serum levels of hLTAA correlate with lung tumor incidence, and appear to usefully discriminate between various stages of the malignancies. The invention further comprises an immunoassay predicated on purified hLTAA for the detection and quantitative determination of hLTAA in biological fluids, particularly blood serum, and diagnostic systems for clinical immunoassay procedures.Type: GrantFiled: January 28, 1983Date of Patent: April 30, 1985Assignee: The Government of the United States as represented by the Secretary of the Department of Health and Human ServicesInventors: James A. Braatz, Kenneth R. McIntire, Gerald L. Princler
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Patent number: 4332244Abstract: An anesthesia mask for laboratory animals comprising a supply tube having a generally conical mask at one end into which the animal's snout is inserted. Pressurized anesthesia gas is delivered through the tube and is prevented from leaking into the ambient environment by means of a second tube which concentrically surrounds the supply tube and is annularly spaced therefrom so that the space can be evacuated by a vacuum source. A holding bar is slidable transversely into the mask to hook onto the animal's incisors.Type: GrantFiled: October 8, 1980Date of Patent: June 1, 1982Assignee: The Government of the United States as represented by the Secretary of Department of Health and Human ServicesInventors: David E. Levy, Alfred Zwies, Thomas E. Duffy