Patents Assigned to The United States Government
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Publication number: 20240184041Abstract: Optical photonic integrated optical clocks on photonic integrated circuits are described. The optical clocks can provide the timing stability of atomic clocks at ultra-low size and power. The optical clocks are be fabricated using CMOS foundry fabrication processes.Type: ApplicationFiled: December 1, 2023Publication date: June 6, 2024Applicants: The Regents of the University of California, The United States Government, as represented by the Secretary of CommerceInventors: Daniel J. Blumenthal, Scott Papp
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Publication number: 20240181015Abstract: Provided herein are compositions and methods of use thereof for the treatment of metabolic disease such as diabetes and obesity. One embodiment provides a method of treating a metabolic disease or syndrome in a subject in need thereof by administering to the subject a therapeutically effective amount of a growth hormone releasing hormone (GHRH) antagonist or a pharmaceutical composition comprising the GHRH antagonist to reduce triglyceride-rich-lipoproteins (TRL) in the subject to treat the metabolic condition or syndrome.Type: ApplicationFiled: April 4, 2022Publication date: June 6, 2024Applicants: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC., UNIVERSITY OF MIAMI, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPT. OF VETERANS AFFAIRSInventors: Neal L. WEINTRAUB, Maritza J. ROMERO LUCAS, Rudolf LUCAS, Andrew SCHALLY, Renzhi CAI
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Publication number: 20240182421Abstract: Described herein are new synthetic routes for production of Endochin-Like Quinolone (ELQ) compounds. Synthetic routes to 3-substituted 4(1H)-quinolones are presented that are amenable to industrial scale preparation. One herein presented approach is relatively short, does not require palladium, and involves no chromatographic separation. A second herein presented approach is similarly relatively short, does not require palladium, involves no chromatographic separation, and also avoids high vacuum distillation. Additionally, both approaches require no protecting group chemistry because the insoluble 4(1H)-quinolone is not formed until the final reaction step.Type: ApplicationFiled: March 17, 2022Publication date: June 6, 2024Applicants: Oregon Health & Science University, The United States Government as Represented by the Department of Veterans AffairsInventors: Michael K. Riscoe, Aaron Nilsen, Haihong Jin, Sovitj Pou, Rolf W. Winter, Rozalia Ana Dodean, Katherine M. Liebman
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Patent number: 11998520Abstract: The present disclosures provides methods for decreasing injuries associated with intraoperative hypotension by intravenously administering to a subject a therapeutically effective amount of a fat emulsion, following a period of intraoperative hypotension and after the subject's mean arterial blood pressure has recovered. The disclosure also provides methods for preventing injuries associated with intraoperative hypotension, particularly for surgical candidates that have an increased risk for intraoperative hypotension. Non-limiting examples of injuries contemplated herein include myocardial injury, myocardial infarction, and acute kidney injury.Type: GrantFiled: September 3, 2021Date of Patent: June 4, 2024Assignee: The United States Government as Represented by the Department of Veterans AffairsInventor: Guy Weinberg
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Patent number: 11999720Abstract: This invention relates to pyrazolylacylpyrazoline compounds or pharmaceutically acceptable salts thereof, and for the use of the compounds to treat neurological disorders.Type: GrantFiled: September 19, 2019Date of Patent: June 4, 2024Assignees: THE TRUSTEES OF INDIANA UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Samy Meroueh, Fletcher A. White, Alexander G. Obukhov
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Patent number: 11992519Abstract: A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed.Type: GrantFiled: June 21, 2021Date of Patent: May 28, 2024Assignees: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services, The United States Government as represented by the Department of Veterans AffairsInventors: Liyanage Parakrama Perera, Thomas Alexander Waldmann, Kevin Charles Conlon, Pin-Yu Perera
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Patent number: 11993640Abstract: Described herein are compositions and methods for treating pulmonary fibrosis and cancer. The compositions include growth hormone releasing hormone peptides. The methods include reducing lung inflammation, lung scarring, reducing expression of T cell receptor complex genes as well as inhibiting tumor growth.Type: GrantFiled: August 6, 2021Date of Patent: May 28, 2024Assignee: The United States Government as Represented by the Department of Veterans AffairsInventors: Robert M. Jackson, Andrew V. Schally, Renzhi Cai
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Patent number: 11986112Abstract: An apparatus can be used for assisting a user in donning a shoe, the shoe having a heel collar and a tongue, wherein the tongue has an underside. The apparatus can comprise a body that is partially receivable into the shoe. The body can have a top portion that is configured to extend above the heel collar when the body is partially received into the shoe. An inner portion can extend downwardly from the top portion. First and second projections that extend forwardly from the body and can be configured to bias against the underside of the tongue on opposing sides of the tongue.Type: GrantFiled: June 22, 2021Date of Patent: May 21, 2024Assignee: United States Government As Represented By The Department Of Veterans AffairsInventors: Seth R. Hills, Garrett S. Bullock
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Patent number: 11987564Abstract: Disclosed are small molecule PTPRD inhibitors and uses thereof. Methods of using the PTPRD inhibitors include methods of treating, preventing, or delaying the progression of a disorder responsive to PTPRD inhibition, including for example nicotine dependence, addiction, obesity, metabolic syndrome, and substance-use disorders such as stimulant-use disorders and opioid-use disorders.Type: GrantFiled: May 2, 2022Date of Patent: May 21, 2024Assignees: Arizona Board of Regents on Behalf of the University of Arizona, The United States Government as respresented by the Department of Veterans Affairs, The University of Kentucky Research FoundationInventors: George Richard Uhl, Ian M. Henderson, Wei Wang, Thomas Prisinzano
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Publication number: 20240156783Abstract: Provided herein are compositions suitable for treating chemically induced eye damage comprising (a) a nonsteroidal anti-inflammatory drug (NSAID), (b) a histone deacetylase (HDAC) inhibitor and (c) an angiotensin converting enzyme (ACE) inhibitor and, optionally, (d) a water-soluble vitamin. Methods of using provided compositions to treat ocular toxicity and corneal damage following exposure to chemical agents (e.g., mustard gas) are also provided.Type: ApplicationFiled: December 20, 2023Publication date: May 16, 2024Applicants: The Curators of the University of Missouri, The United States Government as Represented by the Department of Veterans AffairsInventor: Rajiv R. Mohan
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Publication number: 20240158386Abstract: Compounds which are benzoxazolone derivatives are disclosed, including compounds of the following genus: The compounds possess anti-inflammasome properties and exhibit anti-fibrotic and anti-proliferative effects. They are useful in inhibiting the activation of NLRP3 or NLRC4 receptors, and in the treatment of a variety of neuroinflammatory disorders such as autoimmune diseases, type-2 diabetes, Cryopyrin-Associated Autoinflammatory Syndromes, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, and rheumatoid arthritis.Type: ApplicationFiled: March 1, 2022Publication date: May 16, 2024Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Robert DEVITA, Giulio M. PASINETTI, Maria SEBASTIAN-VALVERDE, Francis HERMAN, Kunal KUMAR
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Patent number: 11980698Abstract: Disclosed herein are contractile cell constructs, methods for using them to treat disease, and methods for making them.Type: GrantFiled: June 1, 2021Date of Patent: May 14, 2024Assignees: Arizona Board of Regents on Behalf of the University of Arizona, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Jordan J. Lancaster, Steven Goldman
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Patent number: 11974709Abstract: A cleaning cart can comprise a body defining an underside and at least one shelf, wherein the body has a footprint. A plurality of wheels can rotatably couple to the body. A sweeping attachment can be coupled to the underside of the body. The sweeping attachment can comprise a slide comprising a track that is coupled to the body and a carriage that is configured to slide relative to the track along an axis about and between a first position that is generally within the footprint of the body and a second position that is generally outside of the footprint of the body. A sweeping assembly can be coupled to the carriage. The sweeping assembly can couple to a sweeping element.Type: GrantFiled: April 1, 2021Date of Patent: May 7, 2024Assignee: United States Government As Represented By The Department Of Veterans AffairsInventors: Larry Hillson, Micah Hambleton
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Patent number: 11972050Abstract: Instances of a single brain computer interface (BCI) system can be implemented on multiple devices. An active instance can control the associated device. The instances can each communicate with a neural decoding system that can receive neural signals from a user, process the neural signals, and output a command based on the processed neural signals. A device running the active instance of can be in communication with the neural decoding system to receive a command. The device can include a display, a non-transitory memory storing instructions, and a processor to execute the instructions to: run an instance of a control program; and execute the task based on the command.Type: GrantFiled: November 1, 2022Date of Patent: April 30, 2024Assignees: BROWN UNIVERSITY, THE GENERAL HOSPITAL CORPORATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Leigh Hochberg, John D. Simeral, Tyler Singer-Clark, Ronnie Gross, Thomas Hosman, Anastasia Kapitonava, Rekha Crawford
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Patent number: 11958786Abstract: A barrier coating system may include a super alloy or ceramic matrix composite (CMC) substrate underneath a bond coat. The barrier coating system may also include a calcium-magnesium aluminosilicate (CMAS) resistant coating configured to protect metallic, or oxide-based or silicon based components in a harsh CMAS environment.Type: GrantFiled: November 28, 2017Date of Patent: April 16, 2024Assignee: UNITED STATES GOVERNMENT ADMINISTRATOR OF NASAInventors: Dongming Zhu, Gustavo Costa
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Patent number: 11957468Abstract: Systems and methods are provided for providing a standardized pressure value representing a transient pressure event within a region of interest within a living body. An air-charged catheter is configured to record pressure data representing the region of interest. A measurement assembly includes a parameter calculation component configured to calculate at least a peak pressure representing the transient pressure event and a time to peak pressure, representing the time necessary to reach the peak pressure, from the recorded pressure data. A standardization component is configured to calculate the standardized pressure value as a function of the peak pressure and the time to peak pressure. A user interface is configured to display at least the standardized pressure value at an associated display.Type: GrantFiled: January 14, 2020Date of Patent: April 16, 2024Assignees: THE CLEVELAND CLINIC FOUNDATION, The United States Government as represented by the Department of Veterans AffairsInventors: Margot S. Damaser, Hassan K. Awada, Paul C. Fletter, Mitchell Cooper, Paul J. Zaszczurynski
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Patent number: 11951136Abstract: Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.Type: GrantFiled: December 12, 2018Date of Patent: April 9, 2024Assignees: The Regents of the University of California, The United States Government as Represented by the Department of Veterans AffairsInventors: Casey Ward, Qizhi Tang, Peter Stock, Gaetano Faleo, Gopika Nair, Matthias Hebrok, Wenhan Chang, Thuy Vo, Jeffrey A. Bluestone, Eleonora De Klerk
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Patent number: 11951152Abstract: This disclosure is directed to therapeutic compositions, and more particularly to microparticle compositions for the controlled delivery of telmisartan and actinomycin D.Type: GrantFiled: September 18, 2020Date of Patent: April 9, 2024Assignees: University of South Florida, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRSInventors: Subhra Mohapatra, Shyam S. Mohapatra, Eleni Markoutsa, Alejandro J. Gonzalez, Heta N. Jadhav
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Patent number: 11951023Abstract: A prosthesis system can comprise an upper arm prosthesis comprising a socket, the upper arm prosthesis being positioned on a first side of the prosthesis system proximate a residual limb of a user. A harness that can be coupled to the socket of the upper arm prosthesis. The harness can comprise a front portion that is configured to extend across the chest of the user and receive at least a portion of the breasts of the user therein and a back portion that is configured to extend across the back of the user and couple to opposed lateral sides of the front portion. A first end of a support strap can couple to the socket of the prosthesis at a first anchor point, and a second end can couple to the back portion of the harness on a second side of the prosthesis system opposite the first side.Type: GrantFiled: December 6, 2021Date of Patent: April 9, 2024Assignee: United States Government As Represented By The Department Of Veterans AffairsInventors: Sandra L. Winkler, Samuel Phillips, Jemy Delikat
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Patent number: 11944426Abstract: A load cell apparatus includes a base member, a cap member, a number of first members provided between the base member and the cap member and forming at least a portion of a support wall of the load cell apparatus, and a plurality of strain gauges directly coupled to the number of first members, the plurality of strain gauges being positioned to measure an axial load applied to the load cell in a direction extending from the cap member to the base member.Type: GrantFiled: January 11, 2019Date of Patent: April 2, 2024Assignees: University of Pittsburgh-Of the Commonwealth System of Higher Education, The United States Government as Represented by the Department of Veterans AffairsInventors: Jonathan L. Pearlman, Jonathan A. Duvall, Samuel T. Bucior