Patents Assigned to The United States Government as represented by the Department of Veterans Affairs
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Patent number: 11911481Abstract: This invention provides for a RSV-targeted nanoparticle PMN (RTPMN), combining HR2D anti-fusion peptide, and plasmid encoded siRNA against RSV-NS1 and/or RSV-P gene as a safe, effective and inexpensive anti-RSV prophylaxis and/or therapy.Type: GrantFiled: May 21, 2019Date of Patent: February 27, 2024Assignees: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, UNIVERSITY OF SOUTH FLORIDAInventors: Eleni Markoutsa, Subhra Mohapatra, Shyam Mohapatra
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Patent number: 11911487Abstract: The present invention provides methods and materials useful delivering liquids, including liquids comprising nucleic acid molecules into cells. In particular, the present invention provides methods for delivering saline solution, exogenous compositions, and isolated vectors to kidney cells, using the renal vein as a guide and under hydrodynamic pressure. The delivery methods and materials herein are useful to research, prognose, ameliorate symptoms of kidney injury, and treat kidney pathologies.Type: GrantFiled: May 3, 2013Date of Patent: February 27, 2024Assignees: Indiana University Research and Technology Corporation, United States Government as Represented by the Department of Veterans AffairsInventors: Robert Bacallao, Simon Atkinson, George Rhodes, Peter Corridon
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Patent number: 11903806Abstract: An artificial urinary sphincter can include a cuff configured to surround a portion of a length of a urethra. An actuator is configured to selectively apply a force to the cuff to thereby apply variable amount of pressure to the urethra. A controller is configured to adjust the application of the force by the actuator to cause the cuff to apply the variable amount of pressure to the urethra. A sensor can be in communication with the controller and configured to detect pressure applied against the cuff by the urethra. The controller is configured to cause the cuff to apply a first closing pressure to the urethra. In response to a detection of a threshold pressure increase by the sensor, the controller is configured to cause the cuff to apply a second closing pressure that is greater than the first closing pressure and that prevents urine from exiting the urethra.Type: GrantFiled: March 1, 2019Date of Patent: February 20, 2024Assignees: United States Government As Represented By The Department Of Veterans Affairs, Wayne State University, University of BaselInventors: Nivedita Dhar, Steven Majerus, Jeremy Rickli, Tino Toepper, Bekim Osmani, Bert Mueller
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Publication number: 20240051965Abstract: Disclosed is an oxygen-containing heterocyclic compound, and use thereof. The present disclosure provides an oxygen-containing heterocyclic compound represented by Formula I, a pharmaceutically acceptable salt thereof, deuterated derivative thereof, a solvate thereof, a solvate of the pharmaceutically acceptable salt thereof or a crystal form thereof, and the oxygen-containing heterocyclic compound is expected to selectively inhibit Smad3 activation.Type: ApplicationFiled: August 4, 2023Publication date: February 15, 2024Applicants: Icahn School of Medicine at Mount Sinai, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Richard T. BERESIS, John Cijiang HE, Kyung LEE
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Patent number: 11896349Abstract: Embodiments discussed herein facilitate determination of a response to treatment and/or a prognosis for a tumor based at least in part on features of tumor-associated vasculature (TAV). One example embodiment is a method, comprising: accessing a medical imaging scan of a tumor, wherein the tumor is segmented on the medical imaging scan; segmenting tumor-associated vasculature (TAV) associated with the tumor based on the medical imaging scan; extracting one or more features from the TAV; providing the one or more features extracted from the TAV to a trained machine learning model; and receiving, from the machine learning model, one of a predicted response to a treatment for the tumor or a prognosis for the tumor.Type: GrantFiled: December 9, 2020Date of Patent: February 13, 2024Assignees: Case Western Reserve University, The United States Government as Represented by The Department of Veteran AffairsInventors: Anant Madabhushi, Nathaniel Braman
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Publication number: 20240043931Abstract: A MS disease activity (MSDA) score is provided as a tool to detect relapse and response to glatiramer acetate (GA) therapy in subjects having relapsing-remitting multiple sclerosis (RRMS) using the blood-based biomarkers SIRT1, RGC-32, FasL, IL-21, pSIRT1 and JNK p54.Type: ApplicationFiled: August 3, 2023Publication date: February 8, 2024Applicants: UNIVERSITY OF MARYLAND, BALTIMORE, The United States Government as represented by the Department of Veterans AffairsInventors: Horea G. Rus, Freidrich ANSELMO, Alexandru TATOMIR
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Patent number: 11891442Abstract: Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells.Type: GrantFiled: December 21, 2018Date of Patent: February 6, 2024Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Anton Wyss-Coray, John Vincent Pluvinage, Michael C. Bassik, Michael Haney, Benjamin Smith, Carolyn Bertozzi
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Patent number: 11883118Abstract: A surgical navigation system may include a processor and a display. The processor may receive a patient image and sensor data captured by a sensor, receive a medical image, generate a hologram of the medical image, perform coregistration between the patient image and the hologram, superimpose the hologram on the patient image, and display the superimposed image. Coregistration may be performed manually via a user interaction, or automatically based on one or more fiducials in the medical image and sensor data related to the fiducials. The system may monitor a change in the environment and update the display correspondingly. For example, the system may monitor a movement of a body of the patient, monitor the size of an organ of the patient as the organ is being under operation, or a movement of the surgical instrument. The sensor may be an augmented reality (AR) sensor in an AR device.Type: GrantFiled: November 10, 2022Date of Patent: January 30, 2024Assignees: United States Government As Represented By The Department Of Veterans Affairs, Hennepin Healthcare Systems, Inc.Inventors: Uzma Samadani, Abdullah Bin Zahid, David P. Darrow
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Patent number: 11883468Abstract: Disclosed are methods of decreasing cachexia in a subject comprising administering to the subject a therapeutically effective amount of bPTH7-34DD or variant thereof. Disclosed are methods of decreasing bone destruction in a subject comprising administering to the subject a therapeutically effective amount of bPTH7-34DD or variant thereof. Disclosed are methods of ameliorating one or more symptoms or side effects of breast or prostate cancer in a breast or prostate cancer patient comprising administering to the subject a therapeutically effective amount of bPTH7-34DD or variant thereof. Disclosed are methods of treating osteoporosis in a subject comprising administering to the subject a therapeutically effective amount of bPTH7-34DD or variant thereof.Type: GrantFiled: October 22, 2020Date of Patent: January 30, 2024Assignee: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: John Chirgwin, Attaya Suvannasankha
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Patent number: 11877938Abstract: Pump systems for use in suspension of a prosthetic device from a residual limb and methods of suspending a prosthetic device from a residual limb are disclosed. The pump systems include a mechanically activated pump having a first compression member coupled to a second compression member, a diaphragm disposed between the first and second compression members, and coupling elements that engage and couple together the first and second compression members. The mechanically activated pump may be connected with an electrically activated pump, forming a hybrid pump system to provide vacuum engagement between a prosthetic device and a residual limb.Type: GrantFiled: October 7, 2020Date of Patent: January 23, 2024Assignees: United States Government As Represented By The Department Of Veterans Affairs, Northwestern UniversityInventors: Ryan J. Caldwell, Matthew J. Major
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Patent number: 11865328Abstract: A customizable headgear assembly for neuropsychological and neurological treatment, monitoring, or testing of a patient. The headgear assembly comprising a structural frame having a plurality of anatomical landmark tabs each individually configured to be located upon an anatomical landmark of a patient's head. The structural frame having first and second portions releasably coupled to enable the first and second portions to be at least partially separated for placement and removal from the patient's head. A plurality of electrode holders being operable coupled to the structural frame each configured to locate an electrode upon a predetermined neurological position of the patient.Type: GrantFiled: March 1, 2021Date of Patent: January 9, 2024Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, The United States Government as represented by the Department of Veterans AffairsInventors: Benjamin Hampstead, Allena Holzworth, Kevin Kramer, Alexander Rothmann, Shannon Ryan
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Patent number: 11865062Abstract: A guide system is provided that uses a plurality of sensors to identify and determine a clear path for an ambulatory vision impaired person. The system includes one or more wheels that rotate to propel the system, a platform supported by the one or more wheels and housing a processor, a rigid harness with a haptic feedback grip that is positioned to be grasped by an operator, and one or more sensors configured to sense information about the environment. In operation, the processor analyzes information sensed by the sensors to identify object in the path of the guide system and sends messages to the operator to allow the operator to avoid the identified objects. The messages may be sent to the operator via the haptic feedback grip or audibly via a speaker or via a wireless connection to a haptic or audio device being worn by the operator.Type: GrantFiled: October 13, 2017Date of Patent: January 9, 2024Assignee: United States Government as Represented by the Department of Veterans AffairsInventor: Brian L. Higgins
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Patent number: 11865125Abstract: Provided herein are formulations effective for and methods of treating or preventing a neurodegenerative disorder in a subject in need thereof that can include administering an amount of an aPKC inhibitor to a subject in need thereof.Type: GrantFiled: December 17, 2021Date of Patent: January 9, 2024Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Robert Vito Farese, Mini Paliyath Sajan, Margaret Genevieve Higgs
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Patent number: 11857550Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; and R1-R10 are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R3 or R8 is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen.Type: GrantFiled: November 19, 2020Date of Patent: January 2, 2024Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The United States Government as Represented By the Department of Veterans AffairsInventors: Beibei Chen, Rama K. Mallampalli
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Patent number: 11850259Abstract: This disclosure relates to topical lithium agents including inhalable lithium agents for treating a viral infection characterized by a cytokine storm in the respiratory tract of a subject such as a human. Topical lithium formulations can be used to mitigate such viral infections, including coronavirus infections.Type: GrantFiled: October 5, 2021Date of Patent: December 26, 2023Assignee: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventor: Carl Ganio
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Publication number: 20230407297Abstract: The present disclosure provides methods and compositions for inhibiting Wnt5a expression in cells such as prostate cancer cells.Type: ApplicationFiled: November 3, 2021Publication date: December 21, 2023Applicants: The Regents of the University of California, The United States Government as represented by the Department of Veterans AffairsInventors: Allen C. Gao, Aiming Yu
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Patent number: 11844779Abstract: Provided herein are formulations that can contain an effective amount of a PKC? inhibitor. Also provided herein are methods of inhibiting a PKC? in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKC?.Type: GrantFiled: September 13, 2021Date of Patent: December 19, 2023Assignees: UNIVERSITY OF SOUTH FLORIDA, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Niketa A. Patel, Rekha S. Patel, Robert Pleasants Sparks, Wayne Charles Guida
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Patent number: 11844724Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.Type: GrantFiled: October 25, 2021Date of Patent: December 19, 2023Assignees: California Institute of Technology, The Regents of the University of California, United States Government represented by the Department of Veterans AffairsInventors: Robert H. Grubbs, Marshall L Stoller, Ying Han, Frank L. Brodie
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Patent number: 11839649Abstract: The invention features probiotic bacteria expressing Clostridium difficile SlpA, or fragment thereof, and its use for the treatment or prevention of Clostridium difficile infection and gut colonization.Type: GrantFiled: January 22, 2021Date of Patent: December 12, 2023Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, The United States Government as represented by the Department of Veterans AffairsInventors: Gayatri Vedantam, Virinchipuram K. Viswanathan, Michael Mallozzi
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Patent number: D1012932Type: GrantFiled: March 16, 2022Date of Patent: January 30, 2024Assignees: UNITED STATE GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Rory A. Cooper, Garrett G. Grindle, Zachary Kitzmiller Anzelone, Aaron Tyler Anderson