Patents Assigned to The United States of America, as rep. by the Sec. Department of Health and Human Services
  • MODULATED PROGRAMMED DEATH LIGAND-1
    Publication number: 20120251514
    Abstract: The invention provides nucleic acids comprising a nucleotide sequence encoding programmed death ligand-1 (PD-L1) and a nucleotide sequence encoding a fusion protein comprising thymidylate kinase (TMPK) or a variant thereof and a cell surface marker or a variant thereof. Recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and kits relating to the nucleic acids are disclosed. Methods of treating or preventing a disease in a host and methods of suppressing an immune system in a host are also disclosed.
    Type: Application
    Filed: November 12, 2010
    Publication date: October 4, 2012
    Applicants: University Health Network, The United States of America, as rep. by the Sec. Department of Health and Human Services
    Inventors: Daniel Fowler, Shoba Amarnath, Jeffrey Medin, James Chian Ming Wang