Patents Assigned to THE UNITED STATES OF AMERICAN, as represented by the Secretary, Department of Health and Human Serv
  • METHOD FOR GENERATING RETINAL PIGMENT EPITHELIUM (RPE) CELLS FROM INDUCED PLURIPOTENT STEM CELLS (IPSCs)
    Publication number: 20150368713
    Abstract: High efficiency methods for producing retinal pigment epithelial cells from induced pluripotent stem cells (iPSCs) are disclosed herein. The iPSCs are produced from somatic cells, including retinal pigment epithelial (RPE) cells, such as fetal RPE stem cells. In some embodiments, the iPSC include a tyrosinase promoter operably linked to a marker. Methods are disclosed for using the RPE cells, such as for treatment. Methods for screening for agents that affect RPE differentiation are also disclosed.
    Type: Application
    Filed: January 31, 2014
    Publication date: December 24, 2015
    Applicant: THE UNITED STATES OF AMERICAN, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Kapil Bharti, Janine Davis, Arvydas Maminishkis, Marc Ferrer-Alegre, Sheldon S. Miller