Abstract: The disclosure relates, in some aspects, to compositions and methods for enhanced delivery of a transgene to the central nervous system (CNS) of a subject. In some embodiments, the transgene is delivered by recombinant AAV (rAAV). In some embodiments, the method of enhancing transgene delivery comprises administering a blood brain barrier (BBB)-crossing molecule (e.g., K16ApoE) and an rAAV comprising a transgene to a subject.

Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).

Abstract: Various embodiments disclosed relate to a method of forming a composite including a carbon composite structure. The method includes disposing a precursor composition on a substrate. The composition includes a porogen component, a carbon component, and a catalyst component. The method further includes irradiating the precursor composition to form the carbon composite structure.

Abstract: Aspects of the disclosure relate to compositions and methods for epigenetic regulation of endogenous gene expression from viral vectors. In some embodiments, the disclosure provides expression constructs comprising a viral vector encoding a transgene, the activation of which is regulated by a rapamycin/rapalog-based system, and the transgene is capable of epigenetically regulate an endogenous gene.

Abstract: Aspects relate to patterned nanostructures having a feature size not including film thickness of below 5 microns. The patterned nanostructures are made up of nanoparticles having an average particle size of less than 100 nm. A nanoparticle composition, which, in some cases, includes a binder, is applied to a substrate. A patterned mold used in concert with electromagnetic radiation function to manipulate the nanoparticle composition in forming the patterned nanostructure. In some embodiments, the patterned mold nanoimprints a pattern onto the nanoparticle composition and the composition is cured through UV or thermal energy. Three-dimensional patterned nanostructures may be formed. A number of patterned nanostructure layers may be prepared and joined together. In some cases, a patterned nanostructure may be formed as a layer that is releasable from the substrate upon which it is initially formed.

Abstract: System, computer products, and methods can improve the resolution of data from a sensor array. One of these methods include receiving, from an analog to digital converter, a series of measurements representing frequency samples and spatial samples from a sensor array. The method includes generating a plurality of factors based on a polynomial. The method includes applying one or more complex weights to the measurements based on the factors. The method includes combining the complex weighted measurements into a plurality of values. The method also includes identifying a characteristic of an object detected by the sensor array based on the plurality of values.

Abstract: Providing explanations in route planning includes determining a route based on at least two objectives received from a user, where a second objective of the at least two objectives is constrained to within a slack value of a first objective of the at least two objectives; receiving, from the user, a request for an explanation as to an action along the route; and providing the explanation to the user. The explanation describes an extent of violating the slack value.

Abstract: Many treatments of skin cancer need an accurate assessment of the margins of the tumor. Spectrally-encoded optical polarization imaging improves upon the demarcation of skin cancer such as keratinocytic carcinomas. When the clinician can outline the clinical boundary of each lesion, surgery and other treatments can be more efficient and effective. Optical images of the lesions are acquired at various wavelengths, then spectrally-encoded. Spectral-encoding of the images minimizes the impact of background pigmentation and vascularization so that the tumor can be accurately visualized.

Abstract: A flexible circuit module is disclosed. The flexible circuit module includes a fabric member including a plurality of fibers having non-conductive elements, and conductive elements oriented through the plane of the fabric. Each conductive element includes a first fiber element strand and a first unterminated end opposite the first fiber element strand, and a second fiber element strand having second unterminated end opposite the second fiber element strand. The fabric member further includes a first side with the first fiber element strands extending therefrom and a second side with second fiber element strands extending therefrom. A first hook-and-loop busbar is conductively connected to the first fiber element strands and a second hook-and-loop busbar is conductively connected to the second fiber element strands.

Abstract: This invention relates to methods and compositions for treatment of inv (16) leukemia and particularly to treatment of acute myeloid leukemia. Disclosed is a method of treating inv (16) leukemia comprising the step of administering to a subject in in need thereof a therapeutically effective combination of a) a compound of the formula (1) (1) and b) a BRD4 inhibitor selected from the group consisting of JQ1, CeMMECZ, 1-BET 151 (or GSK1210151A), 1-BET 762 (or GSK525762), PFI-1, bromosporine, OTX-015 (or MK-8628), TEN-010, CPI-203, CPI-0610, RVX-208, BI2536, TG101348, LY294002, ABBV-075 (or mivebresib), FT-1101, ZEN003694, pharmaceutically acceptable salts and mixtures thereof. The therapeutically effective combination synergistically inhibits proliferation of inv (16) leukemia cells. This invention also relates to pharmaceutical compositions comprising a therapeutically effective combination of the compound of formula (1) and the BRD4 inhibitor and a pharmaceutically acceptable excipient.

Abstract: Provided is a compound according to Formula 1 wherein X, R, R1, R2, R3, and R4 are as defined herein. The compound of Formula 1 can be useful in a composition and in a method for inducing ferroptosis in a cell.

Abstract: A textile-based hydrogel electrode comprises a textile-based backing layer, a conductive structure coupled to the textile-based backing layer, and a hydrogel body in contact with at least a first portion of the conductive structure, wherein the first portion of the conductive structure and the hydrogel body form an ionic interface configured to generate an electrical signal through the conductive structure corresponding to a biopotential change proximate to the textile-based hydrogel electrode.

Abstract: The present invention relates to genomic analysis. In particular, the present invention provides methods and compositions for mapping genomic interactions.

Abstract: Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (111 1) and methods of treating Huntington's disease using the same.

Abstract: In some aspects, the disclosure provides recombinant AAV and nucleic acid constructs having novel inverted terminal repeats (ITRs), cap, and/or rep genes. In some aspects, the disclosure relates to gene transfer methods using rAAVs described herein.

Abstract: The disclosure relates to a method of making carbon fiber, the method comprising pyrolyzing poly(p-phenylene) (PPP) fiber at a temperature sufficient to convert PPP fiber substantially to carbon fiber. The disclosure also relates to pre-PPP polymer, methods for making PPP fiber from pre-PPP polymer and, in turn, making carbon fiber from PPP fiber.

Abstract: Aspects of the disclosure relate to compositions and methods useful for treating ocular ciliopathies, for example Leber congenital amaurosis (LCA). In some embodiments, the disclosure provides isolated nucleic acids comprising a transgene encoding a CEP290 protein fragment, and methods of treating ocular ciliopathies using the same.

Abstract: The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).

Abstract: Real-time decision-making for a vehicle using belief state determination is described. Operational environment data is received while the vehicle is traversing a vehicle transportation network, where the data includes data associated with an external object. An operational environment monitor establishes an observation that relates the object to a distinct vehicle operation scenario. A belief state model of the monitor computes a belief state for the observation directly from the operational environment data. The monitor provides the computed belief state to a decision component implementing a policy that maps a respective belief state for the object within the distinct vehicle operation scenario to a respective candidate vehicle control action. A candidate vehicle control action is received from the policy of the decision component, and a vehicle control action is selected for traversing the vehicle transportation from any available candidate vehicle control actions.

Abstract: A unique point absorber type wave energy conversion device is disclosed that includes a Power Take Off (PTO) which uses a torsion spring to return a vertical shaft to its original position after being rotated by a rope or cord that pulls a reel via a guide system. This spring return allows the PTO and housing to stay stationary under the wave energy while a buoy at the surface provides an oscillating linear movement. The oscillating rotary motion caused by the interaction of the buoy and spring is converted into a one directional motion via a one-way clutch and is transmitted to generators using a gearbox that increases rotational speed.