Patents Assigned to The University of Miami
-
Patent number: 11963786Abstract: Systems, methods, and computer readable media for determining cognitive impairment (CI) in patients are provided herein. Various regional structural-functional parameters of the retina can serve as biomarkers for the detection of CI. The method can include forming a database including a quantification of retinal structure and retinal function of a plurality of eyes associated with a plurality of patients, providing a baseline cognitive impairment (CI) reference. The method can include determining a measure of functionality of neurons in the retina based on an electroretinogram (ERG) of a patient. The method can include determining a structural measure of the first retina based on a generalized dimension spectrum and singularity spectrum of the skeletonized retinal image, and a lacunarity parameter of the skeletonized retinal image. The method can include determining a level of cognitive impairment based on the structural and functional measures.Type: GrantFiled: December 6, 2019Date of Patent: April 23, 2024Assignee: University of MiamiInventor: Delia DeBuc
-
Publication number: 20240124570Abstract: The compositions and methods described herein include methods and agents that inhibit inflammasome signaling in a mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s) or other agents. Also described herein are compositions and methods of use thereof for detecting and treating early-stage Alzheimer's disease as well as other inflammatory neurologic conditions.Type: ApplicationFiled: September 8, 2023Publication date: April 18, 2024Applicant: University of MiamiInventors: Juan Pablo De Rivero Vaccari, Robert W. Keane, W. Dalton Deitrich, Helen M. Bramlett
-
Patent number: 11957569Abstract: A device and method for aspirating graft tissue and delivering the graft tissue to a target delivery site (for example, when performing Descemet's membrane endothelial keratoplasty). In one embodiment, an injector comprises a cylinder and a plunger at least partially located within the cylinder, the plunger being rotatably advanceable and retractable within the cylinder. In one aspect of the embodiment, rotating the plunger in a first direction within the cylinder controllably aspirates a graft tissue into the injector and rotating the plunger in a second direction opposite the first direction controllably ejects the graft tissue from the injector.Type: GrantFiled: February 28, 2020Date of Patent: April 16, 2024Assignees: TissueCor, LLC, University of MiamiInventors: Alfonso L. Sabater, Abhishek Shah, William B. Buras, Alejandro M. Sabater
-
Publication number: 20240108593Abstract: The disclosure provides a method of treating a polyamine imbalance-related disorder. The method comprises administering phenylbutyrate to a subject in need thereof, thereby treating the polyamine imbalance-related disorder.Type: ApplicationFiled: December 6, 2021Publication date: April 4, 2024Applicant: UNIVERSITY OF MIAMIInventors: Rong Grace Zhai, Xianzun Tao, Chong Li, Yi Zhu, Zoraida Diaz-Perez
-
Patent number: 11938198Abstract: The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAP?. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAP? to which PP2A binds.Type: GrantFiled: March 13, 2020Date of Patent: March 26, 2024Assignees: University of Miami, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Michael S. Kapiloff, Jinliang Li
-
Patent number: 11932898Abstract: Computer-implemented processes for precision therapeutic biomarker screening for cancer include using a model-based overlapping clustering framework to assess large numbers of possible drugs and drug combinations against patient data, including cell line responsiveness. A multivariate regression model has been developed, along with a latent overlapping cluster indicator variable. The techniques employ a new finite mixture of multivariate regression (FMMR) model and expectation-maximization (EM) algorithm for modeling. The techniques can analyze large amounts of drug data and identify complex overlapping drug clusters, as well as cluster-wise drivers that facilitate identification of new drugs for treating pathologies, such as cancer, in patients.Type: GrantFiled: July 31, 2017Date of Patent: March 19, 2024Assignee: UNIVERSITY OF MIAMIInventors: Jonnagadda Sunil Rao, Hongmei Liu
-
Publication number: 20240084276Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.Type: ApplicationFiled: November 21, 2023Publication date: March 14, 2024Applicants: Precision Biosciences, Inc., University of MiamiInventors: James Jefferson Smith, Ginger Tomberlin, John Morris, Wendy Shoop, Carlos T. Moraes
-
Patent number: 11926613Abstract: Provided herein are compounds of the general Formula (I) which act as kinase inhibitors, e.g. ROCK, S6K, and/or PKC inhibitors, and are useful in neurite growth and axonal growth.Type: GrantFiled: October 31, 2018Date of Patent: March 12, 2024Assignee: UNIVERSITY OF MIAMIInventors: Hassan Al-Ali, Vance Lemmon, John Bixby
-
Patent number: 11918659Abstract: Described herein are materials and methods for inducing therapeutic hypothermia in a subject in need thereof.Type: GrantFiled: September 19, 2019Date of Patent: March 5, 2024Assignee: UNIVERSITY OF MIAMIInventors: Sylvia Daunert, Suzana Hamdan, Dalton Dietrich, Sapna Deo, Helen Bramlett
-
Patent number: 11911450Abstract: The invention provides a method of treating or preventing pain in a subject in need thereof. The method comprising administering to the subject an expression vector comprising a nucleic acid sequence encoding carbonic anhydrase (10) or carbonic anhydrase (11) such that the nucleic acid is expressed to produce carbonic anhydrase (10) or carbonic anhydrase (11). Alternatively, the method comprising administering to the subject an expression vector comprising a nucleic acid sequence encoding a carbonic anhydrase (8) fragment such that the nucleic acid is expressed to produce the carbonic anhydrase (8) fragment.Type: GrantFiled: July 13, 2018Date of Patent: February 27, 2024Assignee: UNIVERSITY OF MIAMIInventors: Roy Levitt, Gerald Z. Zhuang
-
Patent number: 11913962Abstract: Described herein are materials and methods for stratifying risk for reactivation of a latent viral infection, such as CMV infection. The methods are particularly useful for immune compromised subjects. Also described herein are interventions, including therapeutic, prophylactic, and monitoring interventions, for subjects determined to be at elevated risk.Type: GrantFiled: May 14, 2018Date of Patent: February 27, 2024Assignee: UNIVERSITY OF MIAMIInventors: Krishna Komanduri, Eric Wieder, Jose Camargo, Erik Kimble
-
Patent number: 11866747Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.Type: GrantFiled: January 30, 2023Date of Patent: January 9, 2024Assignees: University of Miami, Precision BioSciences, Inc.Inventors: James Jefferson Smith, Ginger Tomberlin, John Morris, Wendy Shoop, Carlos T. Moraes
-
Patent number: 11850035Abstract: Systems and methods for diagnosing a condition in an individual by analyzing the individual's breath are provided. Sensors may be configured to capture data associated with the breath of an individual. The data captured by the sensors may include a change in resistance measurements recorded by solid-state sensors when the sensors are exposed to the individual's breath at several different temperatures. This captured data may be analyzed to identify one or more volatile organic compound (VOC) biomarkers in the individual's breath. Based on the identified VOC biomarkers, a condition associated with the individual may be determined. For example, a medical condition, or a condition of drowsiness or fatigue associated with the individual may be determined based on the VOC biomarkers in the individual's breath. In some examples, the sensors may be positioned inside a vehicle for determination of condition associated with a driver of the vehicle.Type: GrantFiled: June 25, 2019Date of Patent: December 26, 2023Assignee: UNIVERSITY OF MIAMIInventors: Sylvia Daunert, Jeramy Lee Rueff Baum, Carl Ivan Schulman, Sapna K. Deo, Emre Dikici, Chitvan Killawala, Kelly Withum, Kevin Miller
-
Patent number: 11840565Abstract: The compositions and methods described herein include methods and agents that inhibit inflammasome signaling in a mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s) or other agents. Also described herein are compositions and methods of use thereof for treating viral-associated lung inflammation, for example lung inflammation associated with viral infections such as SARS-CoV-2.Type: GrantFiled: November 12, 2021Date of Patent: December 12, 2023Assignee: UNIVERSITY OF MIAMIInventors: Robert W. Keane, W. Dalton Dietrich, Juan Pablo De Rivero Vaccari, Helen M. Bramlett
-
Methods of designing novel antibody mimetics for use in detecting antigens and as therapeutic agents
Patent number: 11830582Abstract: Provided herein are methods implemented by a processor in a computer for designing a clamp peptide comprising the structure A1-B-A2 wherein A1 is a first peptide arm that binds to a first binding site of a target protein, A2 is a second peptide arm that binds to a second binding site of the target protein, and B is a bridge peptide which links A1 to A2. Also provided herein are computer-readable storage media having stored thereon machine-readable instructions executable by a processor and systems. Related methods of manufacturing a clamp peptide and the clamp peptides manufactures by the methods are provided.Type: GrantFiled: June 14, 2019Date of Patent: November 28, 2023Assignee: UNIVERSITY OF MIAMIInventors: Sylvia Daunert, Sapna K. Deo, Emre Dikici, Marcello Mascini -
Publication number: 20230337905Abstract: In certain embodiments, double-vision-related vision defects determinations or modifications may be facilitated. In some embodiments, a stimulus may be to be presented at a first time at a position on a first display for a deviating eye of a user (e.g., without a stimulus being presented on a second display of for a reference eye of the user) to cause the deviating eye to fixate on the position on the first display. A deviation measurement for the deviating eye may be determined based on an amount of movement of the deviating eye occurring upon the presentation on the first display for the deviating eye at the first time. In some embodiments, a modification profile associated with the user may be determined based on the deviation measurement, where the modification profile includes one or more modification parameters to be applied to modify an image for the user.Type: ApplicationFiled: May 18, 2023Publication date: October 26, 2023Applicant: University of MiamiInventor: Mohamed ABOU SHOUSHA
-
Publication number: 20230296626Abstract: Compositions and methods for detecting components of the inflammasome in a sample from a subject as markers for inflammasome-related diseases or disorders such as multiple sclerosis, stroke, mild cognitive impairment, Alzheimer's disease, age-related macular degeneration, NASH, inflammaging or traumatic brain injury. Methods of using such inflammasome markers to determine prognosis, direct treatment and monitor response to treatment for the subject with an inflammasome-related disease or disorder such as multiple sclerosis, stroke, mild cognitive impairment, Alzheimer's disease, age-related macular degeneration, NASH, inflammaging or traumatic brain injury are also described.Type: ApplicationFiled: April 27, 2021Publication date: September 21, 2023Applicant: University of MiamiInventors: Robert W. Keane, Dalton W. Deitrich, Juan Pablo de Rivero Vaccari, Helen M. Bramlett
-
Patent number: 11730768Abstract: The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles from cell culture supernatants and biological fluids. The present invention also provides pharmaceutical compositions of microvesicles to promote or enhance wound healing, stimulate tissue regeneration, remodel scarred tissue, modulate immune reactions, alter neoplastic cell growth and/or mobility, or alter normal cell growth and/or mobility. The present invention also provides compositions of microvesicles to be used as diagnostic reagents, and methods to prepare the compositions of microvesicles.Type: GrantFiled: October 30, 2019Date of Patent: August 22, 2023Assignee: UNIVERSITY OF MIAMIInventors: Evangelos V. Badiavas, Arsalan Q. Shabbir, Stephen C. Davis
-
Patent number: 11723987Abstract: Provided herein are recombinant expression vector systems for expression by stem cells that allow for selective elimination of stem cell-derived tumorigenic cells, while preserving stem cell-derived therapeutic cells. The systems provided herein provide a means by which modified stem cells can be safely transplanted into subjects. In exemplary embodiments, the system comprises at least two suicide genes, one of which is specifically inactivated in cells exhibiting the desired phenotype and one of which is activated when the cell comprising the recombinant expression vector system behaves similarly to or the same as a tumor cell.Type: GrantFiled: September 15, 2017Date of Patent: August 15, 2023Assignee: UNIVERSITY OF MIAMIInventor: Juan Dominguez-Bendala
-
Publication number: 20230242913Abstract: The present disclosure relates, in general, to oligonucleotides that stimulate STING (STimulator of Interferon Genes) activity and increase activity of immune cells. The disclosed STING activators (STAVs) are useful in the treatment of cancer and other immune-mediated conditions.Type: ApplicationFiled: February 28, 2023Publication date: August 3, 2023Applicant: UNIVERSITY OF MIAMIInventor: GLEN N BARBER