Patents Assigned to The University of Sheffield
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Patent number: 11964944Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.Type: GrantFiled: June 2, 2022Date of Patent: April 23, 2024Assignees: The University of Chicago, J. Craig Venter Institute, Inc., The University of Sheffield, Institute for Systems Biology, The University of Leeds, The University of Strathclyde, The Government of the United StatesInventors: Rima McLeod, Martin McPhillie, Colin W. G. Fishwick, Hernan Alejandro Lorenzi, Kai Wang, Taek-Kyun Kim, Yong Zhou, Leroy E. Hood, Ying Zhou, Kamal El Bissati, Mark Hickman, QiGui Li, Craig Roberts
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Publication number: 20240060960Abstract: The disclosure provides for methods of predicting disease progression comprising detecting a modification of one or more disease markers in a glial cell or neuronal cell generated from a skin cell of the subject. The disclosed methods include methods of identifying subjects that are responsive to a therapeutic agent and methods of determining effectiveness of a therapeutic agent.Type: ApplicationFiled: January 13, 2022Publication date: February 22, 2024Applicants: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, THE UNIVERSITY OF SHEFFIELDInventors: Kathrin Christine Meyer, Cassandra Nicole Dennys-Rivers, Laura Ferraiuolo
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Patent number: 11815477Abstract: A method of non-destructive detection of surface and near surface abnormalities in a metallic product. The method comprises positioning a sample having a surface under a source of an incident radiation. The surface of the sample is then irradiated with the incident radiation from the source. A scattered radiation is detected and a radiation pattern from the detected scattered radiation is produced. Said radiation pattern is then analysed and the output indicative of the scattered radiation from the sample is produced. Said produced output is then compared with a threshold value, the threshold value indicative of a maximum acceptable detected surface abnormality. Finally, the presence of a surface abnormality is identified when the output exceeds the threshold value.Type: GrantFiled: March 25, 2020Date of Patent: November 14, 2023Assignee: THE UNIVERSITY OF SHEFFIELDInventors: Matthew Brown, Peter Lawrence Crawforth, Bradley Peter Wynne, Hassan Ghadbeigi
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Patent number: 11813071Abstract: Apparatus for determining the electrical conductivity of target cervical tissue using magnetic impedance spectroscopy comprising: an excitation coil for producing a magnetic field which is capable of inducing currents in the target cervical tissue; a gradiometer for detecting perturbations in said magnetic field caused by said induced currents, the gradiometer including screening means for minimising sensitivity to tissues other than the target tissue; processing means for determining an electrical conductivity of said target cervical tissue from said perturbations.Type: GrantFiled: December 21, 2016Date of Patent: November 14, 2023Assignee: THE UNIVERSITY OF SHEFFIELDInventors: Brian Brown, Dilichukwu Anumba
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Publication number: 20230313134Abstract: The present invention relates generally to the identification and isolation of human otic progenitor cells. More specifically, the present invention relates to a method of using cell markers to identify and isolate human otic progenitor cells from a mixed population of cells, methods of enrichment and production of human otic progenitor cells, and associated kits for use in identification and/or isolation of human otic progenitor cells, wherein the cell markers are selected from SSEA1 (CD15), disialoganglioside GD3, TRA-2-49 (liver/bone/kidney alkaline phosphatase), SSEA4, ganglioside GD2 and CD141.Type: ApplicationFiled: March 13, 2023Publication date: October 5, 2023Applicant: THE UNIVERSITY OF SHEFFIELDInventors: Carlos Marcelo Nicolas Rivolta, Sarah Louise Boddy
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Patent number: 11660049Abstract: An apparatus for determining a force Ftip applied to a tip of an electrical impedance spectroscopy probe includes a load cell, accelerometer, and a processing means. The probe tip has a substantially planar distal end for contacting human or animal tissue. The load cell measures the force Floadcell applied axially along a longitudinal axis when the probe tip is in contact with human or animal tissue. The accelerometer measures a gravity vector Aaxial. The apparatus includes a means for compensating for the mass of the probe tip using the measured force and the gravity vector to produce a calibrated measurement force F applied to the probe tip.Type: GrantFiled: December 21, 2016Date of Patent: May 30, 2023Assignee: THE UNIVERSITY OF SHEFFIELDInventors: Dilichukwu Anumba, Timothy James Healey
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Patent number: 11634687Abstract: The present invention relates generally to the identification and isolation of human otic progenitor cells. More specifically, the present invention relates to a method of using cell markers to identify and isolate human otic progenitor cells from a mixed population of cells, methods of enrichment and production of human otic progenitor cells, and associated kits for use in identification and/or isolation of human otic progenitor cells, wherein the cell markers are selected from SSEA1 (CD15), disialoganglioside GD3, TRA-2-49 (liver/bone/kidney alkaline phosphatase), SSEA4, ganglioside GD2 and CD141.Type: GrantFiled: September 14, 2017Date of Patent: April 25, 2023Assignee: THE UNIVERSITY OF SHEFFIELDInventors: Carlos Marcelo Nicolas Rivolta, Sarah Louise Boddy
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Publication number: 20230109504Abstract: This disclosure concerns transcription cassettes comprising nucleic acid molecules comprising a nucleotide sequence encoding AP-4 subunits; vectors comprising said transcription cassettes; pharmaceutical compositions comprising said vector; and vectors or compositions for use in the treatment of AP-4-Hereditary Spastic Paraplegia.Type: ApplicationFiled: April 9, 2021Publication date: April 6, 2023Applicant: University of SheffieldInventors: Mimoun Azzouz, Joseph Scarrott, Evangelia Karyka
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Patent number: 11612626Abstract: A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.Type: GrantFiled: February 13, 2020Date of Patent: March 28, 2023Assignees: Virttu Biologics Limited, The University of SheffieldInventors: Joe Conner, Munitta Muthana, Claire Elizabeth Lewis
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Publication number: 20230038479Abstract: The present disclosure relates to transcription cassettes comprising nucleic acids encoding RuvBL1 and/or RuvBL2 and the use of said vectors in gene therapy for the treatment of neurodegenerative diseases that result from expression of polymorphic repeat expansions of the GGGGCC (SEQ ID NO: 5) hexanucleotide-repeat sequence in the first intron of the C9ORF72 gene; pharmaceutical compositions comprising said vectors and including uses and methods to treat neurodegenerative diseases.Type: ApplicationFiled: February 2, 2021Publication date: February 9, 2023Applicant: University of SheffieldInventors: Mimoun Azzouz, Christopher Webster
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Publication number: 20230001146Abstract: A guiding device for a vascular catheter that is inserted over a guidewire. The guiding device comprising a tapered component for passing through a bore of the vascular catheter and extending from a distal end thereof. The tapered component has an aperture through which the guidewire may pass so that the tapered component (12) may move along the guidewire. A pushing means extends from the tapered component and is configured to extend beyond a proximal end of the vascular catheter. The tapered component comprises a first section, a second section and the third section. The first section is disposed between the proximal end of the tapered component and the second section, the second section is disposed between the first section and the third section, and the third section is disposed between the second section and a distal end of the tapered component. The first section is a cylinder and the second and the third sections are conical. The taper of the second section differs from the taper of the third section.Type: ApplicationFiled: November 24, 2020Publication date: January 5, 2023Applicant: THE UNIVERSITY OF SHEFFIELDInventors: Julian Philip George GUNN, Paul David Morris
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Patent number: 11535859Abstract: The present invention relates to the modification of gene expression in plants in order to manipulate stomatal number, in particular to the modification of expression in plants of epidermal patterning factor (EPF). The invention also relates to genetically modified plants or plant parts with altered stomatal patterning compared to corresponding wild type plants or plant parts, where the plant stomatal development is altered by modification of the expression of EPF.Type: GrantFiled: April 26, 2018Date of Patent: December 27, 2022Assignee: The University of SheffieldInventors: Julie Elizabeth Gray, Lee Hunt, William Paul Quick
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Patent number: 11504033Abstract: Polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicating monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.Type: GrantFiled: January 13, 2017Date of Patent: November 22, 2022Assignees: Smith & Nephew PLC, University of SheffieldInventors: John Kenneth Hicks, Richard Hoskins, Stephen Rimmer, Dorothy McCulloch
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Patent number: 11471076Abstract: Device comprising polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicator monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.Type: GrantFiled: January 13, 2017Date of Patent: October 18, 2022Assignees: Smith & Nephew PLC, University of SheffieldInventors: John Kenneth Hicks, Richard Hoskins, Stephen Rimmer, Dorothy McCulloch
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Patent number: 11400081Abstract: Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein R1, R2, R3, R4, R5, R6, R8, R9, X, X1, X2, X3, L1 and n are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.Type: GrantFiled: May 16, 2018Date of Patent: August 2, 2022Assignee: The University of SheffieldInventors: Gareth Richards, Timothy M. Skerry, Joseph P. A. Harrity, Jean-Olivier Zirimwabagabo, Matthew J. Tozer, Karl Richard Gibson, Roderick Alan Porter, Paul Matthew Blaney, Paul Alan Glossop
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Publication number: 20220218790Abstract: The disclosure relates to long acting parathyroid or parathyroid hormone like fusion polypeptides comprising a receptor polypeptide and its use in the treatment of hypoparathyroidism and osteoporosis.Type: ApplicationFiled: March 30, 2022Publication date: July 14, 2022Applicant: University of SheffieldInventors: Ian Wilkinson, Richard Ross
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Publication number: 20220205934Abstract: A method of non-destructive detection of surface and near surface abnormalities in a metallic product. The method comprises positioning a sample having a surface under a source of an incident radiation. The surface of the sample is then irradiated with the incident radiation from the source. A scattered radiation is detected and a radiation pattern from the detected scattered radiation is produced. Said radiation pattern is then analysed and the output indicative of the scattered radiation from the sample is produced. Said produced output is then compared with a threshold value, the threshold value indicative of a maximum acceptable detected surface abnormality. Finally, the presence of a surface abnormality is identified when the output exceeds the threshold value.Type: ApplicationFiled: March 25, 2020Publication date: June 30, 2022Applicant: THE UNIVERSITY OF SHEFFIELDInventor: Matthew BROWN
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Patent number: 11345064Abstract: A method for removing a hollow support element (17) from within a moulded part (15) to form a cavity (25) within the moulded part, the hollow support element being disposed within the moulded part and composed of material having a softening temperature, the method comprising: heating a liquid (20) to a temperature at least equal to the softening temperature of the material; injecting the heated liquid into an opening (24) in the moulded part to deform the material; and removing deformed material and liquid from the cavity.Type: GrantFiled: April 20, 2018Date of Patent: May 31, 2022Assignees: McLaren Automotive Limited, The University of SheffieldInventors: Claudio Santoni, Elaine Arnold, Timothy Swait, Mark Laycock
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Patent number: 11345945Abstract: The present invention provides a polypeptide comprising an N-terminal polypeptide domain having luciferase activity and a C-terminal polypeptide domain having VAMP1, VAMP2 or VAMP3 activity where VAMP stands for vesicle-associated membrane protein. Corresponding nucleic acid molecules, expression vectors and genetically modified cells are also provided. The invention also provides methods and uses of the same.Type: GrantFiled: February 14, 2018Date of Patent: May 31, 2022Assignee: The University Of SheffieldInventors: Bazbek Davletov, Andrew Alexander Peden, Aleksander Mikael Rudolf Rust, Ciara Louise Doran
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Patent number: 11344606Abstract: The disclosure relates to long acting parathyroid or parathyroid hormone like fusion polypeptides comprising a receptor polypeptide and its use in the treatment of hypoparathyroidism and osteoporosis.Type: GrantFiled: April 27, 2018Date of Patent: May 31, 2022Assignee: University of SheffieldInventors: Ian Wilkinson, Richard Ross