Patents Assigned to The University of Tokyo
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Publication number: 20240025901Abstract: A first object of the present invention is to provide a method for producing a cyclic imide compound with high yield and high purity. A second object of the present invention is to provide a composition that can be used in the method for producing a cyclic imide compound with high yield and high purity. A third object of the present invention is to provide an intermediate compound that can be used in the method for producing a cyclic imide compound with high yield and high purity. The method for producing a cyclic imide compound according to the present invention includes reacting a compound represented by formula (1) below with at least one amine compound to obtain a compound represented by formula (2) below.Type: ApplicationFiled: July 13, 2023Publication date: January 25, 2024Applicants: FUJIFILM Corporation, The University of TokyoInventors: Hiroki SUGIURA, Yukio TANI, Tetsuya MATSUSHITA, Tetsuya WATANABE, Toshihiro OKAMOTO
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Publication number: 20240024266Abstract: [Problem] To develop novel therapeutic agents for viral diseases such as coronavirus infections. [Solution] The present invention provides a therapeutic or prophylactic agent for viral diseases containing a compound with inhibitory activity against the function of Pin1 or a pharmaceutically acceptable salt thereof as an active ingredient.Type: ApplicationFiled: November 16, 2021Publication date: January 25, 2024Applicants: Hiroshima University, Tokyo University of Pharmacy & Life Sciences, The University of TokyoInventors: Tomoichiro Asano, Takemasa Sakaguchi, Takeshi Yamamotoya, Yusuke Nakatsu, Hisanaka Ito, Takayoshi Okabe, Jeffrey Encinas
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Patent number: 11879722Abstract: An objective of the present invention is to provide a method, or the like, for estimating the convergence of dimensional changes in a molded article over time, by utilizing the polarization intensity of terahertz waves. The present invention provides a method for estimating the convergence of changes in the dimensions of a molded article over time, the method comprising: irradiating a molded article with terahertz waves at multiple positions thereon, wherein the molded article is irradiated with the terahertz waves at each position thereon in multiple orientations about the optical axis; measuring polarization intensities of the terahertz waves transmitted through or reflected from the molded article; and determining whether the polarization intensities at the multiple positions are in a given relationship with each other.Type: GrantFiled: February 27, 2020Date of Patent: January 23, 2024Assignees: IIDA Co., Ltd., THE UNIVERSITY OF TOKYOInventors: Shigeo Miyake, Yusuke Kajihara, Shuichi Nowatari, Seiichiro Iwasaki, Junya Nowatari
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Patent number: 11878268Abstract: Provided is a method of fixing a sufficient amount of carbon dioxide contained in a carbon dioxide-containing gas (e.g., a plant exhaust gas) simply, at low cost, and efficiently. The method of fixing carbon dioxide includes a contact step of bringing a carbon dioxide-containing gas into contact with powdery or grainy particles, which are each formed of a cementitious hardened body and each have a particle size of 40 mm or less, at a temperature of from 75° C. to 110° C. to fix carbon dioxide contained in the carbon dioxide-containing gas to the powdery or grainy particles, wherein the relative humidity of the carbon dioxide-containing gas is adjusted in accordance with the particle size of the powdery or grainy particles and the state of adjustment of moisture content of the powdery or grainy particles before the contact step.Type: GrantFiled: December 2, 2019Date of Patent: January 23, 2024Assignees: TAIHEIYO CEMENT CORPORATION, THE UNIVERSITY OF TOKYOInventors: Dianchao Wang, Takafumi Noguchi, Takahito Nozaki, Yasuhide Higo
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Publication number: 20240020853Abstract: The invention relates to automatic discovery and evaluation of a motion by treating motion recognition as an optimization problem by considering a series of basic motions obtained by segmenting a subject motion. The method comprises segmenting time series data defining a motion of a subject into a plurality of segments, classifying each segment into a class for a basic motion by using time series data of the segment, and converting the motion of the subject to a sequence of high rank symbols in which each high rank symbol is formed from a series of the basic motions, wherein a function that calculates a score based on a set of a high rank symbol and a sequence of basic motions is provided and the motion of the subject is converted to the sequence of the high rank symbols by an optimization calculation using dynamic programming.Type: ApplicationFiled: August 28, 2019Publication date: January 18, 2024Applicant: THE UNIVERSITY OF TOKYOInventors: Yoshihiko NAKAMURA, Wataru TAKANG, Yosuke IKEGAMI
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Publication number: 20240019323Abstract: An object of the present disclosure is to enable behavior of a linear structure in water to be estimated. The present disclosure is an apparatus that: expresses at least one parameter in a plurality of discrete values, and forecasts behavior of a linear structure by using each of the discrete values; acquires behavior of the linear structure detected using an optical fiber; calculates a likelihood between the forecasted behavior of the linear structure and the acquired behavior of the linear structure; updates at least one of the plurality of discrete values on the basis of the likelihood; and calculates behavior of the linear structure by using the updated plurality of discrete values.Type: ApplicationFiled: October 18, 2021Publication date: January 18, 2024Applicants: NIPPON TELEGRAPH AND TELEPHONE CORPORATION, THE UNIVERSITY OF TOKYOInventors: Takashi MATSUI, Kazuhide NAKAJIMA, Nobutomo HANZAWA, Ryota WADA, Hideaki MURAYAMA
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Publication number: 20240009224Abstract: The present invention provides a nucleic acid having excellent cell membrane permeability.Type: ApplicationFiled: September 1, 2023Publication date: January 11, 2024Applicants: The University of Tokyo, AGC Inc.Inventors: Takashi OKAZOE, Kohsuke AIKAWA, Honoka WATANABE, Akimitsu OKAMOTO, Kunihiko MORIHIRO, Taiichi KAGEYAMA
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Patent number: 11866497Abstract: The present invention provides an antibody to a fibrosis-related molecule and medical application thereof. The antibody of the present invention is an antibody that binds to CHL1 protein and an antibody that neutralizes the binding of the CHL1 protein to a fibroblast.Type: GrantFiled: August 11, 2021Date of Patent: January 9, 2024Assignee: The University of TokyoInventors: Yosuke Kurashima, Hiroshi Kiyono
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Patent number: 11867691Abstract: An image processing device includes a determination unit configured to determine a type of autophagy induced in a cell, based on information indicative of autophagic activity in the cell present in a cell image in which the cell is image captured and based on information indicative of congestion of molecules in the cell present in the cell image.Type: GrantFiled: February 3, 2017Date of Patent: January 9, 2024Assignees: NIKON CORPORATION, THE UNIVERSITY OF TOKYOInventors: Kenta Imai, Mamiko Masutani, Masayuki Murata, Fumi Kano, Yoshiyuki Noguchi
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Patent number: 11867610Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.Type: GrantFiled: January 10, 2023Date of Patent: January 9, 2024Assignees: The University of Tokyo, Osaka UniversityInventors: Sadao Ota, Ryoichi Horisaki, Kazuki Hashimoto
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Publication number: 20240000858Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.Type: ApplicationFiled: December 20, 2022Publication date: January 4, 2024Applicants: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational InstitutionInventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
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Publication number: 20240000050Abstract: The present invention provides a method for preparing a somatic chimera by using a pluripotent cell genetically engineered not to differentiate into a predetermined type of cell. The present invention particularly provides a method for preventing a pluripotent cell from contributing to the brain and gonad in a somatic chimera animal.Type: ApplicationFiled: June 15, 2023Publication date: January 4, 2024Applicant: THE UNIVERSITY OF TOKYOInventors: Hiromitsu NAKAUCHI, Hideyuki SATO, Hideki MASAKI, Motoo WATANABE
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Publication number: 20240000932Abstract: The present invention relates to a novel combination of (1) a substance that suppresses or inhibits the function of extracellular TCTP (translationally controlled tumor protein), especially released from tumor cells, and (2) a cancer immunotherapeutic agent for the treatment of cancer. Preferably, such a cancer immunotherapeutic agent is an immune checkpoint inhibitor. The substance that suppresses or inhibits the function of extracellular TCTP functions as an activator or enhancer of anti-tumor immune cells including T cells and natural killer (NK) cells and/or an antagonist of immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs), in the tumor immune microenvironment (TIME). The combination according to the present invention is useful for treating or preventing cancer. The combination according to the present invention is also useful for alleviating, reverting, or preventing immune suppression in the tumor immune microenvironment.Type: ApplicationFiled: June 30, 2022Publication date: January 4, 2024Applicants: Boostimmune, Inc., The University of TokyoInventors: Gwanghee LEE, Jeonghyun RYOU, Jiwon HUH, Tadatsugu TANIGUCHI, Sho HANGAI, Hideyuki YANAI
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Patent number: 11856927Abstract: The present invention has found that chimeric animals suffer from noticeable inflammation after birth, though neither immune response nor inflammation in the fetal period of these animals has been reported hitherto. This is an unexpected finding since chimeric animals in the fetal period were exclusively analyzed in prior studies and thus it is deemed that immunotolerance has been theoretically established therein. The present invention provides a composition for suppressing immune response or inflammation in the fetal period of a born chimeric animal.Type: GrantFiled: January 25, 2018Date of Patent: January 2, 2024Assignee: The University of TokyoInventors: Hiromitsu Nakauchi, Tomoyuki Yamaguchi, Sanae Hamanaka, Hideyuki Sato, Hideki Masaki, Naoaki Mizuno, Motoo Watanabe
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Patent number: 11861889Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.Type: GrantFiled: November 29, 2022Date of Patent: January 2, 2024Assignees: The University of Tokyo, Osaka UniversityInventors: Sadao Ota, Issei Sato, Katsuhito Fujiu, Satoko Yamaguchi, Kayo Waki, Yoko Itahashi, Ryoichi Horisaki
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Publication number: 20230417459Abstract: A refrigeration cycle apparatus includes a refrigerant circuit and an adsorbent. The refrigerant circuit includes a compressor that compresses a refrigerant. The refrigerant circuit configures a vapor compression refrigeration cycle in which the refrigerant circulates. The adsorbent adsorbs and desorbs the refrigerant circulating in the refrigerant circuit. The adsorbent adsorbs and desorbs the refrigerant in accordance with a change in a pressure of the refrigerant circulating in the refrigerant circuit.Type: ApplicationFiled: June 27, 2023Publication date: December 28, 2023Applicants: DAIKIN INDUSTRIES, LTD., The University of TokyoInventors: Eiji KUMAKURA, Ryuhei KAJI, Hiroki UEDA, Masaki TANAKA, Kosuke NISHIMURA, Kazuhiro FURUSHO, Yoshimasa KIKUCHI, Hirofumi DAIGUJI, Arun MAJUMDAR, Wei-Lun HSU, Jubair Ahmed SHAMIM
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Publication number: 20230414765Abstract: A polymer represented by the following formula (I): wherein each symbol is as described in the specification, is useful as a drug carrier in effectively delivering a drug to a target site.Type: ApplicationFiled: September 8, 2023Publication date: December 28, 2023Applicants: AGC INC., THE UNIVERSITY OF TOKYO, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Mihoko HARA, Rintaro HARA, Kanjiro MIYATA, Mitsuru NAITO, Takanori YOKOTA
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Publication number: 20230417460Abstract: A refrigerant circuit includes a compressor that compresses refrigerant and an expansion mechanism that decompresses refrigerant. The refrigerant circuit configures a vapor compression refrigeration cycle in which the refrigerant circulates. The adsorbent adsorbs and desorbs the refrigerant circulating in a first unit. The refrigerant circuit includes a high-pressure region and a low-pressure region. The refrigeration cycle apparatus is operated under at least one of a first condition and a second condition. In the first condition, the refrigerant in the high-pressure region has a pressure lower than or equal to a critical pressure of the refrigerant, and the refrigerant in the high-pressure region has a temperature exceeding a critical temperature of the refrigerant.Type: ApplicationFiled: June 27, 2023Publication date: December 28, 2023Applicants: DAIKIN INDUSTRIES, LTD., The University of TokyoInventors: Eiji KUMAKURA, Hirofumi DAIGUJI, Arun MAJUMDAR, Wei-Lun HSU, Jubair Ahmed SHAMIM
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Patent number: 11854751Abstract: The present invention provides a light-transmitting electrode which has high electrical conductivity and high electron blocking performance. The present invention also provides a solar cell which is capable of achieving high energy conversion efficiency at low cost. The present invention provides a method for producing a light-transmitting electrode that has a light-transmitting substrate, a carbon nanotube film which is formed directly or indirectly on the light-transmitting substrate, and a metal oxide film which is formed directly on the carbon nanotube film. This production method includes vapor depositing the metal oxide film, which contains oxygen and a metal element belonging to the group 4, 5 or 6 of the periodic table, on one surface or both surfaces of the carbon nanotube film. The present invention provides a light-transmitting electrode which includes a light-transmitting substrate and a conductive carbon nanotube film that is formed directly or indirectly on the light-transmitting substrate.Type: GrantFiled: January 15, 2021Date of Patent: December 26, 2023Assignees: The University of Tokyo, Aalto University, Denso CorporationInventors: Shigeo Maruyama, Yutaka Matsuo, Il Jeon, Kehang Cui, Esko I. Kauppinen, Albert G. Nasibulin
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Patent number: 11851648Abstract: A mammalian or avian cell line that expresses high levels of human influenza virus receptors is provided. In one embodiment, the cell line supports human influenza virus, e.g., human A/H3 influenza virus, isolation and growth much more effectively than corresponding conventional (unmodified) cells or in corresponding human virus receptor-overexpressing cells, and the propagated viruses may maintain higher genetic stability than in the corresponding cells.Type: GrantFiled: February 7, 2020Date of Patent: December 26, 2023Assignees: Wisconsin Alumni Research Foundation (WARF), The University of TokyoInventors: Yoshihiro Kawaoka, Kosuke Takada, Masaki Imai