Abstract: Methods for inducing plasticity in effector T cells to exhibit a regulatory T cell phenotype, treating an autoimmune disease, enriching Treg cells, and preparing a subject for an organ transplant are described. The methods involve the synergstic inhibition of eIF5A and Notch signaling. Also described are compositions and kits including an eIF5A inhibitor and a Notch signaling inhibitor.

Abstract: Stably consolidated compounds assembled from a statin and a metformin analog, and metabolically labile dual prodrugs assembled from the same, methods of making both, and methods of using them to treat metabolic diseases such as cancers are described.

Abstract: A mouse model that develops type 1 diabetes spontaneously and used thereof are described. In some embodiments, the mouse model expresses a combination of HLA-DQ8 and GAD65 in a C57BL/6-BTBR congenic background, where the GAD65 is expressed under the rat insulin promoter.

Abstract: A sensor for formaldehyde gas, methods of making the same, and methods of using the same, are described.

Abstract: Hybrid molecules having pharmacophores of a ferrotoptosis inducer and an HDAC inhibitor, as well as ferroptosis inducers and HDAC inhibitors, and methods of making and using the same, are described.

Abstract: Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.

Abstract: Entirely carbohydrate immunogens, monoclonal antibodies generated from immune responses to entirely carbohydrate immunogens, vaccine compositions, pharmaceutical compositions, and methods of making and using the same, are described.

Abstract: An IVC filter retrieval device useful for removing an IVC filter from a blood vessel, and useful for removing a tilted IVC filter causing the hook to be embedded in the side (wall) of a blood vessel from the blood vessel, and methods for using the same are described. The IVC retrieval device can be used to retrieve other foreign bodies such as, but not limited to, catheters and wires that may become detached from their devices and released into the blood vessels.

Abstract: The present invention relates to an improved urinary catheter for efficiently draining urine from a urinary bladder of a patient. The improved urinary catheter includes a soft tip that is friendly to the urinary bladder. The improved urinary catheter further includes longer drainage port for proper irrigation of the catheter and thus make it simple to use and better tolerability. In addition, the improved urinary catheter also includes a catheter plug allowing the patient to move more freely and use lavatory rather than using a urine bag all the time.

Abstract: Methods measuring properdin function and kits for conducting ELISA Assays using anti-properdin antibodies and uses thereof are described.

Abstract: A method for extracting a metal species from a solution is described, where the metal species comprises a rare earth element, Th, or U. The method involves the use of poly(caffeic acid) as a sorbent material. The poly(caffeic acid) may be crosslinked with a diamine crosslinker such as ethylenediamine.

Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.

Abstract: Exosomes that express peptides in CD9 proteins, and smart exosomes that co-express two peptides incorporated into CD9 proteins to home delivery of the exosomes to a desired target and evade phagocytosis by macrophages, are described. Provided are exosomes useful for delivering drugs to desired targets. The exosomes comprise drugs, such as chemotherapeutic drugs, encapsulated in their core. The targets include pancreatic cancer cells.

Abstract: Fluorescence-based ratiometric assessment of centrioles (FRAC), and methods of using the same and assays utilizing the same, are described. FRAC allows for the diagnosis of male infertility by analyzing centriole quality of sperm.

Abstract: Methods for promoting bone growth, preventing bone damage, and regulating collagen production, involving the administration of a 14-3-3zeta protein or 14-3-3zeta mRNA, are described.

Abstract: Advanced drying systems including a vehicle having a fuzzy inference system with a speed control logic set containing fuzzy logic rules, a lane change logic set containing fuzzy logic rules, or both, and related methods and systems are described.

Abstract: Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.

Abstract: An aspiration catheter useful for intracranial thrombus removal is described, along with methods of using the same. The aspiration catheter includes an adjustable tip having sides that are adjustable by an operator through the use of pull wires that extend along, and protrude from, the aspiration catheter.

Abstract: Antimicrobial metallic foams useful in filters, methods of making and using the same, and antimicrobial filters, systems, and articles are described.

Abstract: Plasma jet assemblies utilizing evanescent mode cavity resonators, and methods of making the same and using the same, are described.