Patents Assigned to The University of Western Ontario
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Publication number: 20190307638Abstract: An oral device includes an intraoral bolus simulator comprising an exterior surface and having an interior volume Tillable with a fluid. An extraoral user interface extends from the bolus simulator, and can be used to locate or position the intraoral bolus simulator. In various embodiments, the fluid may be a gas or a liquid, or combinations thereof. In other embodiments, an oral device includes an extraoral handle, a shield connected to the handle, a tether extending from the shield, and a bolus simulator connected to the tether.Type: ApplicationFiled: December 12, 2017Publication date: October 10, 2019Applicants: Trudell Medical International, The University of Western OntarioInventors: Ruth E. Martin, Marcus Sieffert, Peter Scarrott, Andreas Rifani, Kelly Armstrong
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Patent number: 10413690Abstract: The present invention relates generally to an oral device, or mouthpiece, for delivering a fluid to the mouth or oropharynx of a user. In one embodiment, the oral device includes an intraoral portion, an extraoral portion, and an auxiliary support device that serves to stabilize the oral device. In various embodiments, the auxiliary support device may be configured with ear loops, a support band, a support frame and/or a support member. The intraoral portion generally includes at least one outlet port through which the fluid is delivered to the oral cavity or oropharynx. A method of dispensing a fluid using the oral device is also provided.Type: GrantFiled: April 13, 2016Date of Patent: September 17, 2019Assignees: The University of Western Ontario, Trudell Medical InternationalInventors: Ruth E. Martin, Michael Nuttall, Bryan Finlay, Julie Theurer, Brandon Coultes
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Patent number: 10400944Abstract: Disclosed is a counterbalance system for moving a payload and a method for counterbalancing the payload. The system and method comprise a resilient member that is in communication with the payload to be moved and two resilient members that are in communication with either end of the first resilient member. An actuator is in communication with the first and third resilient members and a payload arm, attached to the payload, is in communication with the first and second resilient members. The resilient members may be compressed and relaxed during movement of the actuator and the payload arm so that energy may be transferred between the system and the payload to counterbalance the weight of the payload.Type: GrantFiled: March 31, 2015Date of Patent: September 3, 2019Assignees: Centre for Imaging Technology Commercialization, The University of Western OntarioInventors: Jeffrey Bax, Christopher Waring, Aaron Fenster
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Patent number: 10322215Abstract: Functionalized copolymers of isoolefins and conjugated diolefins, methods of preparing the copolymers, and their use as compatibilizers are disclosed. The diolefin monomer units of the co-polymer are modified at the C—C double bond along the backbone of the copolymer to include an oxygen containing functional group such as epoxide, ester or alcohol. The functionalized copolymers improve the wettability of a non-hydrophilic surface towards hydrophilic polymer and allows for the formation of homogenous layers of the hydrophilic polymers. In particular, the spreading of a hydrophilic polymer on a non-hydrophilic substrate is facilitated by applying the co-polymers as an interfacial layer between the two incompatible materials. The resulting coated substrates exhibit resistance to protein adsorption and cell growth after grafting. The co-polymers are especially suited in the coating of biomedical devices where a high degree of uniformity of the coated surface is required.Type: GrantFiled: August 11, 2011Date of Patent: June 18, 2019Assignees: LANXESS INTERNATIONAL SA, UNIVERSITY OF WESTERN ONTARIOInventors: Goran Stojcevic, Gilles Arsenault, Elizabeth R. Gillies, Collin V. Bonduelle, Matthew J. McEachran
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Patent number: 10274499Abstract: The present invention relates to variant SH2 domains for binding a phosphotyrosine (pTyr)-containing peptide. The variant SH2 domains of the present invention include a parent SH2 domain having at least one amino acid substitution in a pre-defined region of 15 amino acid positions of the parent SR2 domain, wherein said at least one amino acid substitution increases the affinity of the variant SH2 domain for the pTyr-containing peptide relative to the parent SH2 domain. The present application relates also to methods of using the variant SH2 domains in the treatment of protein kinase-associated disorders, or the diagnosis or prognosis of protein kinase-associated disorders, for isolating and measuring the concentration of pTyr-containing molecules, and as reagents in research.Type: GrantFiled: March 27, 2013Date of Patent: April 30, 2019Assignees: THE UNIVERSITY OF WESTERN ONTARIO, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Shun-Cheng Li, Tomonori Kaneko, Xuan Cao, Sachdev Singh Sidhu, Haiming Huang
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Patent number: 10266633Abstract: A resin composition containing the reaction product of a 5-hydroxymethyl furfural (HMF) produced in-situ from e.g., glucose and a phenolic compound. Phenolic compounds include phenol, cardanol and bio-phenol. The resin is heat-curable using cross-linking agents such as tetraethylammonium chloride or lignin, etc.Type: GrantFiled: February 20, 2015Date of Patent: April 23, 2019Assignee: THE UNIVERSITY OF WESTERN ONTARIOInventors: Chunbao Xu, Yongsheng Zhang, Zhongshun Yuan
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Patent number: 10220363Abstract: A reactor comprises a reactor vessel defining a confined reactor volume, a support assembly extending about a periphery of the confined reactor volume, a basket positioned within the reactor vessel and supported by the support assembly, the basket having an interior surface and an exterior surface, a downflow zone being defined between the exterior surface of the basket and an interior surface of the confined reactor volume, an inlet screen positioned adjacent to one end of the interior surface and an outlet screen positioned adjacent to an opposite end of the interior surface, an upflow zone defined between the inlet screen and outlet screen, the inlet screen and the outlet screen containing a quantity of particulate catalyst, and a circulating device positioned above said upflow zone and configured to continuously circulate fluid upwardly though said upflow zone and downwardly through said downflow zone, the support assembly and the basket configured to promote the formation of a fluid vortex within a portiType: GrantFiled: May 3, 2017Date of Patent: March 5, 2019Assignee: The University of Western OntarioInventor: Hugo de Lasa
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Patent number: 10214609Abstract: Self-immolative polymers degrade by an end-to-end depolymerization mechanism in response to the cleavage of a stabilizing end-cap from the polymer terminus. Examples include homopolymers, mixed polymers including block copolymers, suitable for a variety of applications. A polyglyoxylate can be end-capped or capped with a linker as in a block copolymer.Type: GrantFiled: May 6, 2015Date of Patent: February 26, 2019Assignee: THE UNIVERSITY OF WESTERN ONTARIOInventors: Elizabeth R. Gillies, Bo Fan, Andrew D. Wong, John F. Trant
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Publication number: 20190055416Abstract: A polymer nanocomposite coating of an elastomeric film containing at least 30 wt % conductive nanoparticles based on combined weight of elastomer and conductive nanoparticles is provided. The conductive nanoparticles have an average particle size along each dimension of less than 500 nm for nanoparticles having an aspect ratio of less than 20:1 or have an average particle size along each dimension of less than 2000 nm for nanoparticles having an aspect ratio of 20:1 or greater. The conductive nanoparticles are formed into hierarchical micro- and nano-sized aggregates having re-entrant morphology. The coating is both superoleophobic and conductive and retains these properties even when stretched under strain to over 100%. The coatings may be produced with simple spray technology.Type: ApplicationFiled: December 9, 2016Publication date: February 21, 2019Applicants: ARLANXEO Singapore Pte. Ltd., University of Western OntarioInventors: Lorenzo P. FERRARI (deceased), Dana K. ADKINSON, Jun YANG, Binyu YU, Maxim PALIY, Brad KOBE
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Patent number: 10088751Abstract: The present disclosure discloses a method of fabrication of free standing open pore membranes with uniform pore size and shape and ordered pore distribution, and its use for synthesis of nanoparticle patterns. The method includes applying a photoresist layer to the top surface of a substrate, heating the photoresist layer for a period of time, and exposing the photoresist layer to a dose of ultraviolet radiation through a mask having a predetermined pattern. The dose of ultraviolet radiation is controlled in intensity and time and the photoresist layer is exposed such that a top portion of the photoresist layer through which the dose of ultraviolet radiation enters the photoresist layer undergoes greater cross linking than a bottom portion of the photoresist layer immediately adjacent to the top surface of the substrate such that a cross linking gradient develops through a thickness of the photoresist layer.Type: GrantFiled: November 27, 2017Date of Patent: October 2, 2018Assignee: THE UNIVERSITY OF WESTERN ONTARIOInventors: Jun Yang, Tingjie Li
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Publication number: 20180256656Abstract: The present invention relates to therapeutic use of a combination of Myxoma virus, including in combination with rapamycin. Treatment with rapamycin enhances the ability of Myxoma virus to selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon. The combination of rapamycin and Myxoma virus can be used to treat diseases characterized by the presence of such cells, including cancer. The invention also relates to therapeutic use of Myxoma virus that does not express functional M135R.Type: ApplicationFiled: May 7, 2018Publication date: September 13, 2018Applicant: The University of Western OntarioInventors: Douglas Grant McFadden, John Barrett, Marianne Michelle Stanford
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Patent number: 10052083Abstract: An actuator for an ultrasound probe comprises a housing assembly configured to accommodate an ultrasound probe and to be positioned adjacent to a target region of interest to be examined, and a motor assembly coupled to the housing assembly, the motor assembly configured to move the housing assembly in a manner to allow an ultrasound probe when accommodated by the housing assembly to perform a compound scan of the target region of interest.Type: GrantFiled: March 28, 2013Date of Patent: August 21, 2018Assignee: UNIVERSITY OF WESTERN ONTARIOInventors: Kevin Barker, Aaron Fenster, Hamid Neshat, Nirmal Kakani
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Patent number: 10054650Abstract: A magnetic resonance imaging method comprises performing imaging where more than one polarizing magnetic field strength is used during scanning and processing at least one image resulting from the scanning to yield an enhanced contrast image.Type: GrantFiled: December 9, 2014Date of Patent: August 21, 2018Assignee: THE UNIVERSITY OF WESTERN ONTARIOInventors: Jamu Alford, Blaine Chronik, Brian Rutt
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Patent number: 10028885Abstract: An oral device, or mouthpiece, for delivering a fluid to the mouth or oropharynx of a user includes an intraoral portion and an extraoral portion, which may be integrally formed. In various embodiments, the oral device may be configured with ear loops. The intraoral portion generally includes at least one outlet port through which the fluid is delivered to the oral cavity or oropharynx. A method for making an oral device is also provided.Type: GrantFiled: March 14, 2014Date of Patent: July 24, 2018Assignees: THE UNIVERSITY OF WESTERN ONTARIO, TRUDELL MEDICAL INTERNATIONALInventors: Ruth E. Martin, Michael Nuttall, Bryan Finlay, Julie Theurer, Brandon Coultes
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Patent number: 10004657Abstract: A method of activating the brain of a subject by delivering at least one gas pulse or fluid pulse of a predetermined amplitude and duration to a predetermined area or areas on the subject's body.Type: GrantFiled: February 4, 2009Date of Patent: June 26, 2018Assignee: THE UNIVERSITY OF WESTERN ONTARIOInventors: Ruth E. Martin, Peter Soros
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Patent number: 9987315Abstract: The present invention relates to therapeutic use of a combination of Myxoma virus, including in combination with rapamycin. Treatment with rapamycin enhances the ability of Myxoma virus to selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon. The combination of rapamycin and Myxoma virus can be used to treat diseases characterized by the presence of such cells, including cancer. The invention also relates to therapeutic use of Myxoma virus that does not express functional M135R.Type: GrantFiled: October 9, 2013Date of Patent: June 5, 2018Assignee: The University of Western OntarioInventors: Grant McFadden, John Barrett, Marianne Stanford
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Patent number: 9987162Abstract: Described herein is a head cooling system comprising: a source of compressed breathable gas; a vortex tube comprising an inlet, a hot gas outlet and a cold gas outlet, the inlet operably connected to the source of compressed breathable gas; and an interface for delivering cooled gas to a nasopharyngeal cavity in fluid communication with the cold gas outlet. The head cooling system may be used in a method to reduce neurodegeneration in a subject, for example neurodegeneration from ischemia, anoxia, cardiac arrest, trauma or neurodegenerative disease. The head cooling system may also be used in a method to prophylactically protect a subject at risk of neurodegeneration, for example neurodegeneration from ischemia, anoxia, cardiac arrest, trauma or neurodegenerative disease.Type: GrantFiled: March 20, 2015Date of Patent: June 5, 2018Assignee: THE UNIVERSITY OF WESTERN ONTARIOInventors: Ting-Yim Lee, Mohammad Fazel Bakhsheshi, Lynn Keenliside
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Patent number: 9945586Abstract: Methods and systems for use with solar devices. The present invention may be used with solar panels, solar dishes, or any other devices for which an optimal exposure to the sun is desired. The present invention first adjusts an azimuth of the solar device until an optimal solar exposure, from an azimuth point of view, is achieved. Then, an altitude of the solar collector is adjusted until an optimal solar exposure, from an altitude point of view, is achieved. The invention also uses a load compensation mean to alleviate the amount of lifting or braking torque needed from the motor to tilt the solar collector.Type: GrantFiled: September 21, 2012Date of Patent: April 17, 2018Assignee: THE UNIVERSITY OF WESTERN ONTARIOInventors: Kamran Siddiqui, Hassan Hassan
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Patent number: 9855187Abstract: An oral device includes an intraoral bolus simulator having an exterior surface and an interior volume fillable with a fluid. An extraoral user interface extends from the bolus simulator, and can be used to locate or position the intraoral bolus simulator. In various embodiments, the fluid may be a gas or a liquid, or combinations thereof. In other embodiments, an oral device includes an extraoral handle, a shield connected to the handle, a tether extending from the shield, and a bolus simulator connected to the tether.Type: GrantFiled: March 28, 2013Date of Patent: January 2, 2018Assignees: Trudell Medical International, The University of Western OntarioInventors: Ruth E. Martin, Marcus Sieffert, Peter Scarrott, Andreas Rifani, Kelly Armstrong
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Patent number: 9829793Abstract: The present disclosure discloses a method of fabrication of free standing open pore membranes with uniform pore size and shape and ordered pore distribution, and its use for synthesis of nanoparticle patterns. The method includes applying a photoresist layer to the top surface of a substrate, heating the photoresist layer for a period of time, and exposing the photoresist layer to a dose of ultraviolet radiation through a mask having a predetermined pattern. The dose of ultraviolet radiation is controlled in intensity and time and the photoresist layer is exposed such that a top portion of the photoresist layer through which the dose of ultraviolet radiation enters the photoresist layer undergoes greater cross linking than a bottom portion of the photoresist layer immediately adjacent to the top surface of the substrate such that a cross linking gradient develops through a thickness of the photoresist layer.Type: GrantFiled: October 3, 2012Date of Patent: November 28, 2017Assignee: THE UNIVERSITY OF WESTERN ONTARIOInventors: Jun Yang, Tingjie Li