Abstract: Embodiments relate to the use of auxetic geometries to construct the pores of membranes. Auxetic geometries expand in the transverse direction when stretched along the longitudinal direction. This behavior is counterintuitive as most materials contract in the transverse direction when stretched longitudinally. A mesh with pores that are auxetic has the potential to overcome the primary limitation of most prolapse meshes—pore collapse with tensile loading.
Type:
Application
Filed:
January 11, 2022
Publication date:
July 14, 2022
Applicant:
Magee-Womens Research Institute & Foundation
Inventors:
Katrina Marquita Knight, Pamela A. Moalli, Steven D. Abramowitch, Ken Gall
Abstract: The present invention relates to an improved micro drop culture dish which is comprised of a substantially flat bottom surface portion and a wall portion integrally secured thereto. The bottom surface portion and wall portion are constructed of a rigid, transparent material. A plurality of circular wells having open upper surfaces are embedded into the substantially flat bottom surface portion as integral, concave indentations. These wells may also be cylindrical in shape with one end integrally attached in a perpendicular manner to the bottom surface portion. The wells may be concentrically arranged in a six-around-one manner, or in a variety of other useful patterns. The bottom surface portion may have numerical or alphabetical markings which identify individual wells for tracking purposes. This micro drop culture dish may be fitted with a detachable cover which is about 8 mm deep and of a size and shape which would allow it to cooperatively and circumferentially attach to the wall portion of the dish.
Abstract: The present invention describes the production of interferon-.tau. proteins and polypeptides derived therefrom. The antiviral and anticellular proliferation properties of these proteins and polypeptides are disclosed. One advantage of the proteins of the present invention is that they do not have cytotoxic side-effects when used to treat cells. Structure/function relationships for the interferon-.tau. protein are also described. In one aspect, the invention includes ovine interferon-.tau.. In another aspect the invention includes multiple forms of human interferon-.tau..
Abstract: The present invention describes the production of interferon-.tau. proteins and polypeptides derived therefrom. The antiviral and anticellular proliferation properties of these proteins and polypeptides are disclosed. One advantage of the proteins of the present invention is that they do not have cytotoxic side-effects when used to treat cells. Structure/function relationships for the interferon-.tau. protein are also described. In one aspect, the invention includes ovine interferon-.tau.. In another aspect the invention includes multiple forms of human interferon-.tau..