Abstract: A reusable sterilization pouch 10 comprises a pair of sheets 7, 9 that provide first and second sides 12, 14 of the pouch, and a closure 16. The sheets are edge-bonded along both side edges and along the bottom edge to provide sealing seams 13, 15 and 17, respectively. The closure 16 comprises a transverse open-ended channel 19 extended across the top of the pouch and a closure strip 18 that is inserted through the channel 19. Channel 19 is large enough that closure strip 18 can be manually inserted therethrough; channel 19 may be slightly larger, but it should not be so large that closure strip 18 would be so loosely contained that it could fall out of the channel when the pouch 10 is held or tilted on edge. Channel 19 is formed by doubling or folding one end of the sheet 9, comprising side 14, back onto itself and edge-bonding the overlap to provide a transverse seam 20.