Abstract: A method for pumping and oxygenating blood includes receiving a flow of gas including oxygen into a gas inlet manifold via a gas inlet. The flow of gas is passed through the hollow fibers from the gas inlet manifold to a gas outlet manifold. The flow of gas is output from the gas outlet manifold via a gas outlet. An impeller is rotated to generate a flow of blood that flows over the hollow fibers. Oxygen from the flow of gas is transferred to the flow of blood through the hollow fibers. Carbon dioxide is transferred from the flow of blood to the flow of gas through the hollow fibers.

Abstract: An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).

Abstract: An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).

Abstract: A flow rate of a fluid in a flow system is determined based on one or more parameters of the flow system, the parameters not including the flow rate itself. The flow rate is also measured with a calibration sensor, and the measured flow rate is used to calibrate how the flow rate is determined.

Abstract: A self-expanding cannula providing a conduit through a skin between an inside of a corpus and an outside of the corpus is disclosed. The self-expanding cannula includes a body encompassing a lumen, and has a distal-end to be positioned outside of the corpus for attachment to an extracorporeal fluid handling system and having a proximal-end to be positioned inside of the corpus, for attachment to an organ of an human or an animal. The body of the self-expanding cannula is constructed from a braided-wire, so that the self-expanding cannula is capable of expanding from a closed diameter to an opened diameter. A catheter-sheath and a catheter-sheath-assembly as well as to a method for applying and positioning a self-expanding cannula, and a catheter-sheath-assembly are disclosed.

Abstract: An expandable conduit-guide providing a leak-tight conduit through a skin between an inside of a corpus and an outside of the corpus is disclosed. The conduit-guide includes a body encompassing a lumen extending essentially axially along a center-line, and has a distal-end to be positioned outside of the corpus, and a proximal-end to be positioned inside of the corpus. The body of the conduit-guide is constructed from a braided-wire so that the conduit-guide is capable of actively expanding from a closed diameter to an opened diameter with the placement of the medical device positioned within the lumen (110) and passively collapsing from the opened diameter to the closed diameter upon withdrawal of the medical device under a spring load of the braided-wire. A catheter-sheath and a catheter-sheath-assembly, as well as to a method for applying and positioning an expandable conduit-guide (1), catheter-sheath (8) and a catheter-sheath-assembly (800) are disclosed.

Abstract: An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).