Patents Assigned to Tissue Engineering
-
Publication number: 20230293771Abstract: The disclosure provides a chondrocyte cell sheet comprising one or more layers of confluent cells comprising chondrocytes and chondroprogenitor cells. Methods of generating cartilage tissue in a subject are also provided. The disclosure also provides a method for producing chondrocyte cell sheets comprising culturing chondrocytes and chondroprogenitor cells in culture solution on a temperature-responsive polymer which has been coated onto a substrate surface of a cell culture support, wherein the temperature-responsive polymer has a lower critical solution temperature in water of 0-80° C.; adjusting the temperature of the culture solution to below the lower critical solution temperature, whereby the substrate surface is made hydrophilic and adhesion of the cell sheet to the surface is weakened; and detaching the cell sheet from the culture support.Type: ApplicationFiled: July 16, 2021Publication date: September 21, 2023Applicants: UNIVERSITY OF UTAH RESEARCH FOUNDATION, ORGANIZATION OF CELL SHEET TISSUE ENGINEERING REGENERATIVE MEDICINE INITIATIVESInventors: Mimi Egami, David Grainger, Kyungsook Kim, Makoto Kondo, Travis Maak, Teruo Okano, Hideaki Sakai
-
Patent number: 11744923Abstract: The present invention relates to a monolithic multi-layered material having at least a first layer, from which anisotropic pores originate, and a second layer, in which the anisotropic pores continue. The present invention further relates to a monolithic medical material having at least a first layer, from which anisotropic pores originate, and a second layer, in which the anisotropic pores continue. The present invention further relates to a process for the production of a multi-layered material having anisotropic pores. It further relates to a multi-layered material which can be produced by the process according to the invention.Type: GrantFiled: January 21, 2020Date of Patent: September 5, 2023Assignee: TETEC Tissue Engineering Technologies AGInventors: Kai Stuckensen, Uwe Gbureck, Juergen Groll
-
Patent number: 11642439Abstract: The present disclosure relates to injectable and expandable compositions, devices, kits and methods for use in an approach for the in-situ foaming of polymers for bone or tissue defects, namely to fill and/or fuse a tissue defect. The present disclosure relates to compositions, devices, kits and methods for use in an approach for the in-situ foaming of polymers for bone or tissue defects, namely for bone tissue defect filling/fusion. The design of extendable and expandable compositions for bone fusion is one of the most challenging fields in the intersection of polymer and biomedical engineering. An aspect of the present disclosure relates to an injectable expandable composition for use in medicine, veterinary or cosmetic, comprising a polycaprolactone particle filler; a polydopamine adhesive bound to said filler; a polymethacrylic acid plasticizer bound to said polydopamine adhesive.Type: GrantFiled: October 15, 2018Date of Patent: May 9, 2023Assignees: UNIVERSIDADE DO MINHO, ASSOCIATION FOR THE ADVANCEMENT OF TISSUE ENGINEERING AND CELL BASED TECHNOLOGIES & THERAPIES (A4TEC)—ASSOCIAÇĂOInventors: Ana Rita Cruz Duarte, Rui L. Reis, Jorge Manuel Nunes Correia Pinto, Rui Miguel Fernandes Duarte
-
Patent number: 11554160Abstract: Products, systems and methods are disclosed for lowering the concentrations of at least one of preservatives and fibrils in a liquid insulin composition. One method comprises replacing at least a portion of at least one of phenol and m-cresol with at least one of cyclodextrins, cyclodextrin polymers, cyclodextrin beads, and an ion exchange resin.Type: GrantFiled: October 29, 2020Date of Patent: January 17, 2023Assignee: Cell and Molecular Tissue Engineering, LLCInventors: Ulrike W. Klueh, Donald L. Kreutzer
-
Patent number: 11491001Abstract: Disclosed herein are medical products, including an implantable device coated with a crosslinked extracellular matrix comprising at least one of Type IV collagen and laminin, wherein the crosslinked extracellular matrix contains no more than 0.024 mg/ml total concentration of glucose, amino acids and salts having a molecular weight of 2000 daltons or less. Corresponding systems and method also are disclosed.Type: GrantFiled: August 22, 2019Date of Patent: November 8, 2022Assignee: Cell and Molecular Tissue Engineering, LLCInventors: Ulrike W. Klueh, Donald L. Kreutzer
-
Patent number: 11351289Abstract: The present disclosure relates to a silk-fibroin ink suitable for 3D printing. The ink for 3D printing now disclosed may be used in chemical and pharma industries, medicine, engineering, manufacturing namely for the production of capsules, fibres, membranes, particles, scaffolds, medical devices, microfluidic devices and patient-specific implants.Type: GrantFiled: June 11, 2018Date of Patent: June 7, 2022Assignee: ASSOCIATION FOR THE ADVANCEMENT OF TISSUE ENGINEERING CELL BASED TECHNOLOGIES & THERAPIES (A4TEC)—ASSOCIAÇÃOInventors: João Pedro Bebiano e Costa, Joana Catarina Da Silva Correia de Oliveira, Joaquim Miguel Antunes Correia de Oliveira, Rui Luís Gonçalves Dos Reis
-
Patent number: 11324855Abstract: A cell-free combination for use in the controlled, especially decelerated or retarded, release of active ingredient and/or in the production of a formulation in hydrogel form, especially depot formulation in hydrogel form, and/or as a formulation in hydrogel form, especially depot formulation in hydrogel form, and/or for the coating of a medical product, especially implant, preferably with a formulation in hydrogel form, especially depot formulation in hydrogel form, wherein the cell-free combination comprises a first component and a second component, the first component comprising crosslinkable albumin and the second component comprising a crosslinking agent for the albumin. Additionally, a hydrogel-forming material or hydrogel, to a kit or multicomponent system, to a medical product or a pharmaceutical formulation, to a discharge device, and to uses of the cell-free combination and of the hydrogel-forming material or hydrogel.Type: GrantFiled: April 24, 2018Date of Patent: May 10, 2022Assignee: TETEC Tissue Engineering Technologies AGInventors: Christoph Gaissmaier, Nils Clausen, Karin Benz
-
Patent number: 11241518Abstract: An object of the invention is to provide a cartilage regenerative material that is capable of regenerating bone and cartilage using cells. Provided is a cartilage regenerative material including a cell construct, which includes biocompatible polymer blocks and stem cells, in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the stem cells.Type: GrantFiled: October 22, 2019Date of Patent: February 8, 2022Assignees: FUJIFILM Corporation, JAPAN TISSUE ENGINEERING CO., LTD.Inventors: Kentaro Nakamura, Hayato Miyoshi, Satoko Hada, Masatoki Watanabe
-
Patent number: 11167013Abstract: The present disclosure relates to a composition for the release of the bioactive substance comprising: sucrose acetate isobutyrate dissolved in an ionic liquid and an additive selected from the list consisting of: chitin, silk fibroin, cellulose, alginate, chitosan, gellan gum, dextrin, collagen, guar gum, carregeenan, heparin, kefiran, or mixtures thereof. By taking advantage of the properties of an ionic liquid (IL), in particular 1-butyl-imidazolium acetate (BMIMAc), it was possible to achieve a good dissolution of SAIB, which combined with chitin and/or silk, natural polymers, allows the development of the structures with different shape and sizes.Type: GrantFiled: June 11, 2018Date of Patent: November 9, 2021Assignee: ASSOCIATION FOR THE ADVANCEMENT OF TISSUE ENGINEERING CELL BASED TECHNOLOGIES & THERAPIES (A4TEC)—ASSOCIAÂOInventors: Cristiana Da Mota Martins Gonçalves, Simone Dos Santos Silva, Fátima Raquel Azevedo Maia, Hajer Radhouani, Joaquim Miguel Antunes Correia De Oliveira, Rui Luís Gonçalves Dos Reis
-
Patent number: 11160902Abstract: An object of the invention is to provide a cartilage regenerative material that suppresses infiltration of fibrous soft tissue and brings about satisfactory cartilage regeneration, and a method for producing the cartilage regenerative material. Provided is a cartilage regenerative material including a porous body of a biocompatible polymer and a biocompatible polymer film, in which the porous body contains chondrocytes and cartilage matrix, and the cartilage matrix exists in a region of 10% or more of a region extending from the surface of the transplant face of the porous body to a depth of 150 ?m along the thickness.Type: GrantFiled: September 15, 2017Date of Patent: November 2, 2021Assignees: FUJIFILM Corporation, JAPAN TISSUE ENGINEERING CO., LTD.Inventors: Kentaro Nakamura, Hayato Miyoshi, Satoko Hada, Masatoki Watanabe
-
Patent number: 11065364Abstract: A combination comprising, spatially separate from one another, a first component and a second component, where the first component comprises crosslinkable albumin and the second component comprises a polymer, wherein non-terminal monomer units of the polymer comprise at least partially, more particularly only partially, an albumin-crosslinking group. Additionally disclosed is a reaction product obtainable by means of the combination, to a medical device, to a medicinal product for innovative therapies, to a kit, to a discharge apparatus, and to a functionalized hyaluronic acid.Type: GrantFiled: August 28, 2017Date of Patent: July 20, 2021Assignee: TETEC Tissue Engineering Technologies AGInventors: Helmut Wurst, Nils Clausen, Nina Baldassi
-
Patent number: 10821156Abstract: Products, systems and methods are disclosed for lowering the concentrations of at least one of preservatives and fibrils in a liquid insulin composition. One method comprises replacing at least a portion of at least one of phenol and m-cresol with at least one of cyclodextrins, cyclodextrin polymers, cyclodextrin beads, and an ion exchange resin.Type: GrantFiled: April 12, 2017Date of Patent: November 3, 2020Assignee: Cell and Molecular Tissue Engineering, LLCInventors: Ulrike W. Klueh, Donald L. Kreutzer
-
Publication number: 20200069841Abstract: An object of the invention is to provide a cartilage regenerative material that is capable of regenerating bone and cartilage using cells. Provided is a cartilage regenerative material including a cell construct, which includes biocompatible polymer blocks and stem cells, in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the stem cells.Type: ApplicationFiled: October 22, 2019Publication date: March 5, 2020Applicants: FUJIFILM Corporation, JAPAN TISSUE ENGINEERING CO., LTD.Inventors: Kentaro NAKAMURA, Hayato MIYOSHI, Satoko HADA, Masatoki WATANABE
-
Patent number: 10576042Abstract: The present disclosure relates to a composition of at least one predominantly positively charged polyelectrolyte polymer and at least one predominantly negatively charged polyelectrolyte polymer, a preferred composition comprises poly-L-lysine and a gellan gum, preferably a methacrylate gellan gum. The present subject-matter further relates to methods for generating composition of the present disclosure and to uses of a mixture according to the disclosure for biomedical applications such as cellular and acellular systems for tissue engineering and regenerative medicine applications or as drug delivery systems, for the treatment of several diseases namely diabetes mellitus.Type: GrantFiled: November 23, 2016Date of Patent: March 3, 2020Assignee: ASSOCIATION FOR THE ADVANCEMENT OF TISSUE ENGINEERING CELL BASED TECHNOLOGIES & THERAPIES ASSOCIAÇAOInventors: Silvia Cristina Araújo Vieira, Joaquim Miguel Antunes De Oliveira, Rui Luís Gonçalves Dos Reis, Joana Catarina Da Silva Correia
-
Publication number: 20190282621Abstract: The present disclosure relates to a blood derivatives based nanocomposite materials incorporating comprising oxidized cellulose nanocrystals, methods for their production, and uses thereof. Also disclosed herein is a method for the production of oxidized cellulose nanocrystals with gradients of sulfation degree and their use to modulate the affinity of protein content of blood derivatives/cellulose nanocrystals nanocomposite materials. Therefore, the present disclosure is useful use in regenerative medicine and/or tissue engineering.Type: ApplicationFiled: October 27, 2017Publication date: September 19, 2019Applicant: ASSOCIATION FOR THE ADVANCEMENT OF TISSUE ENGINEERING AND CELL BASED TECHNOLOGIES & THERAPIES A4TEC-Inventors: Bárbara Bruna DA SILVA MENDES, Rui Miguel DE ANDRADE DOMINGUES, Maria Manuela ESTIMA GOMES, Pedro Miguel DE SOUSA BABO, Rui Luís GONÇALVES DOS REIS
-
Patent number: 10405961Abstract: Disclosed herein are medical products, including a surgical mesh, with a layer of dehydrated modified basement membrane preparation formed thereon. The basement membrane has been modified before dehydration of remove low molecular weight components. In some embodiments, the basement membrane is crosslinked. Methods of making and using the products also are disclosed.Type: GrantFiled: September 2, 2016Date of Patent: September 10, 2019Assignee: Cell and Molecular Tissue Engineering, LLCInventors: Ulrike W. Klueh, Donald L. Kreutzer
-
Patent number: 10370631Abstract: An inner bag of a cell culture package is enclosed in an outer bag such that a rubber stopper is exposed to the outside. A closed space surrounded by the outer surface of the inner bag and the inner surface of the outer bag is sterile. This allows the outer surface of the inner bag, which is used for containing cell-containing deformable materials, to be maintained in a sterile condition. Since the cell culture package can be sterilized before a cell-containing deformable material is placed therein, the sterilization conditions can be relatively easily determined without considering the influence on the cell-containing deformable material. In addition, a holder allows liquid to pass through the bottom surface and side surface of a recess and the bottom surface and the side surface of a cover.Type: GrantFiled: November 6, 2014Date of Patent: August 6, 2019Assignee: JAPAN TISSUE ENGINEERING CO., LTD.Inventor: Makoto Sugiura
-
Publication number: 20190216976Abstract: An object of the invention is to provide a cartilage regenerative material that suppresses infiltration of fibrous soft tissue and brings about satisfactory cartilage regeneration, and a method for producing the cartilage regenerative material. Provided is a cartilage regenerative material including a porous body of a biocompatible polymer and a biocompatible polymer film, in which the porous body contains chondrocytes and cartilage matrix, and the cartilage matrix exists in a region of 10% or more of a region extending from the surface of the transplant face of the porous body to a depth of 150 ?m along the thickness.Type: ApplicationFiled: September 15, 2017Publication date: July 18, 2019Applicants: FUJIFILM Corporation, JAPAN TISSUE ENGINEERING CO., LTD.Inventors: Kentaro NAKAMURA, Hayato MIYOSHI, Satoko HADA, Masatoki WATANABE
-
Publication number: 20190154703Abstract: The invention relates to markers for use in vitro in the prognosis of a clinical outcome (outcome prognosis) of an autologous disc cell transplantation, in the progress assessment/progress monitoring of an autologous disc cell transplantation, in the assessment of the quality of intervertebral disc cells, in the assessment of the quality of an implant and/or advanced therapy medicinal products (ATMP) for the treatment of an intervertebral disc defect, and/or in the diagnosis of an intervertebral disc and/or spinal column defect and a corresponding in vitro method.Type: ApplicationFiled: April 25, 2017Publication date: May 23, 2019Applicant: TETEC Tissue Engineering Technologies AGInventors: Christoph GAISSMAIER, Karin BENZ, Bernd ROLAUFFS
-
Patent number: 10251730Abstract: The present invention provides an implant body formed from metal or ceramics as a raw material, the implant body including a modified surface, provided with a plurality of projections and a plurality of crevasse-like nanoscale grooves, by which focal adhesion formation, penetration of collagen fibers, arrangement of the collagen fibers in a single direction to thereby adhere to connective tissue, and soft tissue sealablity are possible. According to such a surface modification, focal adhesion formation and the arrangement of the cell cytoskeleton can be enhanced, and penetration of collagen fibers into the surface internal portion is possible.Type: GrantFiled: February 18, 2015Date of Patent: April 9, 2019Assignee: IMPLANT AND TISSUE ENGINEERING DENTAL NETWORK-TOKYO, LIMITED COInventor: Eiji Kato