Patents Assigned to Tokai University Educational System
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Patent number: 10524940Abstract: Provided is a stent having a novel structure, the stem simultaneously having both the stability of shape against the action of external force, such as compression force, tensile force, or torsional force, and high flexibility in the direction of twisting of the stem. Connection groups are provided at three or more positions set at circumferentially equally-spaced intervals, the connection groups each including connection sections which are disposed circumferentially close to each other between axially adjacent tubular divided bodies. The connection groups on both sides axially of each of the tubular divided bodies are provided at positions circumferentially offset from each other while at least one turning portion is present between the connection groups.Type: GrantFiled: May 12, 2014Date of Patent: January 7, 2020Assignees: TOKAI UNIVERSITY EDUCATIONAL SYSTEM, NIPRO CORPORATIONInventors: Yuji Ikari, Kuniaki Matsumoto
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Publication number: 20190255121Abstract: An object of the present invention is to provide an agent for promoting expression of N-acetylgalactosaminyltransferase that contains an extract from inflamed tissues inoculated with vaccinia virus. The present invention demonstrated that the extract from inflamed tissues inoculated with vaccinia virus promotes the expression of N-acetylgalactosaminyltransferase in intervertebral disc cells. Thus, the extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract is useful as an agent for promoting the expression of N-acetylgalactosaminyltransferase in intervertebral disc cells.Type: ApplicationFiled: February 19, 2019Publication date: August 22, 2019Applicants: TOKAI UNIVERSITY EDUCATIONAL SYSTEM, NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Daisuke SAKAI, Tomoko NAKAI, Mitsuru NAIKI, Yoji SHIBAYAMA
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Patent number: 10314834Abstract: According to the present invention, there is provided a pharmaceutical composition for treating Philadelphia chromosome positive lymphocytic leukemia, including a thalidomide derivative and BCR-ABL tyrosine kinase inhibitor. According to the present invention there is also provided a method of treating Philadelphia chromosome positive lymphocytic leukemia, including administering a thalidomide derivative and a BCR-ABL tyrosine kinase inhibitor to a patient suffering from Philadelphia chromosome positive lymphocytic leukemia.Type: GrantFiled: September 9, 2016Date of Patent: June 11, 2019Assignees: UNIVERSITY OF YAMANASHI, TOKAI UNIVERSITY EDUCATIONAL SYSTEMInventors: Kanji Sugita, Kiyoshi Ando
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Patent number: 10286014Abstract: Simplification of a preparation step of a cell population used for the treatment of ischemic diseases, and provision of a cell population that shows more effective treatment are shown. A method of producing a cell population wherein a vascular endothelial progenitor cell and/or an anti-inflammatory macrophage are/is enriched, including cultivating a mononuclear cell derived from bone marrow, cord blood or peripheral blood in a serum-free medium containing stem cell factor, interleukin-6, FMS-like tyrosine kinase 3 ligand, thrombopoietin and vascular endothelial cell growth factor, and proliferating vascular endothelial progenitor cell from the cell; and a cell population obtained by the method are shown.Type: GrantFiled: September 30, 2013Date of Patent: May 14, 2019Assignees: FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE, TOKAI UNIVERSITY EDUCATIONAL SYSTEM, STEMMED INC., JUNTENDO EDUCATIONAL FOUNDATIONInventors: Takayuki Asahara, Haruchika Masuda, Rika Tanaka
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Patent number: 10254649Abstract: A method for producing an optical waveguide composing an optical path conversion component having an extremely low signal loss, allowing a high surface packaging density and high speed operation, and allowing high productivity. A method for producing an optical waveguide that propagates light from a surface of a support to an oblique direction not vertical to the surface, the method for producing an optical waveguide comprising the steps of: (1) providing an anti-reflective coating on the support; (2) placing a photosensitive resin composition on the anti-reflective coating, and exposing the photosensitive resin composition to a light ray entering from a direction non-vertical to the surface of the support through a photomask for curing the composition; and (3) removing the unexposed photosensitive resin composition by development; and an optical waveguide obtained by the method.Type: GrantFiled: October 16, 2014Date of Patent: April 9, 2019Assignees: TOKAI UNIVERSITY EDUCATIONAL SYSTEM, NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Osamu Mikami, Kentaro Ohmori, Hideyuki Nawata
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Publication number: 20180243476Abstract: Provided is a cell sheet suitable for cartilage repair. The present invention provides a cell sheet for cartilage repair, formed from a culture of cells derived from a cartilage tissue, and the cell sheet is negative for immunostaining using an antibody against type II collagen. The present invention also provides a method for producing a cell sheet for cartilage repair, formed from a culture of cells derived from a cartilage tissue, and the method includes culturing cells derived from a cartilage tissue on a surface of a membrane, where a temperature-responsive polymer is immobilized on the surface, to give the cell sheet. The culturing is stopped before the cell sheet becomes positive for immunostaining using an antibody against type II collagen.Type: ApplicationFiled: August 30, 2017Publication date: August 30, 2018Applicants: CellSeed Inc., TOKAI UNIVERSITY EDUCATIONAL SYSTEMInventors: Masato SATO, Chikako SATO, Tomomi KOTOKU, Tomoko KAWAKE
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Publication number: 20180243284Abstract: According to the present invention, there is provided a pharmaceutical composition for treating Philadelphia chromosome positive lymphocytic leukemia, including a thalidomide derivative and BCR-ABL tyrosine kinase inhibitor. According to the present invention there is also provided a method of treating Philadelphia chromosome positive lymphocytic leukemia, including administering a thalidomide derivative and a BCR-ABL tyrosine kinase inhibitor to a patient suffering from Philadelphia chromosome positive lymphocytic leukemia.Type: ApplicationFiled: September 9, 2016Publication date: August 30, 2018Applicants: UNIVERSITY OF YAMANASHI, TOKAI UNIVERSITY EDUCATIONAL SYSTEMInventors: Kanji SUGITA, Kiyoshi ANDO
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Publication number: 20180187215Abstract: Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally relates to compositions, methods, and kits for DNA editing using single-stranded DNA. Compositions and methods for modifying gene expression using artificial microRNAs (amiRNA) are also contemplated.Type: ApplicationFiled: February 7, 2018Publication date: July 5, 2018Applicants: Board of Regents of the University of Nebraska, Tokai University Educational SystemInventors: Channabasavaiah B. Gurumurthy, Hiromi Miura, Masato Ohtsuka
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Patent number: 9777951Abstract: Disclosed is a thermoacoustic engine having: resonance pipes including a working gas; motors; and a branch pipe, where each of the motors has a regenerator, a heater, and a cooler, a temperature gradient is given between both ends of the regenerator to generate self-excited oscillation of the working gas, a channel cross-sectional area of the resonance pipe that is coupled to the heater is expanded by a same amplification factor of a work flow based on the self-excited oscillation or by an amplification factor within a range of ±30% of the amplification factor of the work flow to a channel cross-sectional area of a resonance pipe that is coupled to the cooler, and a channel cross-sectional area of the regenerator is set by 4 to 36 times of the channel cross-sectional area of the resonance pipe that is coupled to the cooler.Type: GrantFiled: November 30, 2012Date of Patent: October 3, 2017Assignee: Tokai University Educational SystemInventors: Shinya Hasegawa, Yasuo Oshinoya, Tsuyoshi Yamaguchi, Tomohiro Kaneko
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Publication number: 20160252816Abstract: A method for producing an optical waveguide composing an optical path conversion component having an extremely low signal loss, allowing a high surface packaging density and high speed operation, and allowing high productivity. A method for producing an optical waveguide that propagates light from a surface of a support to an oblique direction not vertical to the surface, the method for producing an optical waveguide comprising the steps of: (1) providing an anti-reflective coating on the support; (2) placing a photosensitive resin composition on the anti-reflective coating, and exposing the photosensitive resin composition to a light ray entering from a direction non-vertical to the surface of the support through a photomask for curing the composition; and (3) removing the unexposed photosensitive resin composition by development; and an optical waveguide obtained by the method.Type: ApplicationFiled: October 16, 2014Publication date: September 1, 2016Applicants: TOKAI UNIVERSITY EDUCATIONAL SYSTEM, NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Osamu MIKAMI, Kentaro OHMORI, Hideyuki NAWATA
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Patent number: 9095551Abstract: An object of the present invention is to enable the repair and regeneration of articular cartilage, which could not be achieved by conventional therapies, and to provide a safe and inexpensive agent that is effective for the treatment of joint diseases such as osteoarthritis. According to the present invention, a combined formulation for simultaneously, separately, or sequentially administering a hyaluronic acid and an animal mucin-type glycoprotein for the treatment of joint diseases is provided.Type: GrantFiled: January 29, 2010Date of Patent: August 4, 2015Assignees: RIKEN, TOKAI UNIVERSITY EDUCATIONAL SYSTEMInventors: Kiminori Ushida, Koji Kihira, Takayuki Baba, Kayoko Taniguchi, Makoto Urai, Masato Sato, Naoshi Ohta, Joji Mochida
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Patent number: 9040111Abstract: A method of making a stent, including preparing a solution containing a composition, the composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, including argatroban, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 3:7, the composition dissolved in a solvent selected from the group consisting of a mixture of a lower alkyl ketone and methanol, a mixture of a lower alkyl ester and methanol or a mixture of a lower halogenated hydrocarbon and methanol; coating at least an outer surface of a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces; and after the coating, removing the solvent to complete a first coated layer.Type: GrantFiled: December 28, 2012Date of Patent: May 26, 2015Assignees: JAPAN STENT TECHNOLOGY CO., LTD., TOKAI UNIVERSITY EDUCATIONAL SYSTEM, TOYO ADVANCED TECHNOLOGIES CO., LTD.Inventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
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Patent number: 8968392Abstract: A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.Type: GrantFiled: July 30, 2012Date of Patent: March 3, 2015Assignees: Japan Stent Technology Co., Ltd., Tokai University Educational System, Toyo Advanced Technologies Co., Ltd., Hiroo IwataInventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
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Patent number: 8903469Abstract: A velocity-image creating unit creates a velocity image that indicates a distribution of velocity components with respect to each of a plurality of images obtained by repeating a plurality of number of times Echo Planar Imaging (EPI) that is capable of obtaining velocity components of a Cerebrospinal Fluid (CSF) flowing inside a subject. A velocity-variance image creating unit calculates variance of velocity components along the time sequence by same position on velocity images by using a plurality of created velocity images. A superimposed-image processing unit then superimposes the distribution of the variance of the velocity components according to the velocity-variance image on an average absolute-value image, and an image display unit displays a superimposed image.Type: GrantFiled: October 2, 2009Date of Patent: December 2, 2014Assignees: Tokai University Educational Systems, Toshiba Medical Systems CorporationInventors: Shinya Yamada, Hitoshi Kanazawa
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Patent number: 8903470Abstract: A velocity-image creating unit creates a velocity image that indicates a distribution of velocity components with respect to each of a plurality of images obtained by repeating a plurality of number of times Echo Planar Imaging (EPI) that is capable of obtaining velocity components of a Cerebrospinal Fluid (CSF) flowing inside a subject. A velocity-variance image creating unit calculates variance of velocity components along the time sequence by same position on velocity images by using a plurality of created velocity images. A superimposed-image processing unit then superimposes the distribution of the variance of the velocity components according to the velocity-variance image on an average absolute-value image, and an image display unit displays a superimposed image.Type: GrantFiled: August 9, 2012Date of Patent: December 2, 2014Assignees: Tokai University Educational Systems, Toshiba Medical Systems CorporationInventors: Shinya Yamada, Hitoshi Kanazawa
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Patent number: 8821882Abstract: A vaccine preparation characterized in that Neospora caninum-derived dense granule protein 7 or apical membrane antigen 1 or an immunologically active variant or derivative thereof is included in liposomes each having an oligosaccharide capable of binding to a carbohydrate recognition molecule on the surface of antigen-presenting cells on the surface of the liposome.Type: GrantFiled: September 11, 2009Date of Patent: September 2, 2014Assignees: Obihiro University of Agriculture and Veterinary Medicine, Tokai University Educational SystemInventors: Yoshifumi Nishikawa, Naoaki Yokoyama, Naoya Kojima
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Patent number: 8641756Abstract: A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.Type: GrantFiled: June 8, 2012Date of Patent: February 4, 2014Assignees: Japan Stent Technology Co., Ltd., Tokai University Educational System, Toyo Advanced Technologies Co., Ltd., Hiroo Iwata Institute for Frontier Medical Sciences, Kyoto UniversityInventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
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Publication number: 20140031710Abstract: An apparatus for determining sleep apnea includes: an expiratory gas collector which is configured to collect an expiratory gas of a subject; an analyzer which is configured to analyze a constituent and a concentration of the constituent in the collected expiratory gas; and a determiner which is configured to determine whether the subject is in sleep apnea or not, based on a concentration of at least VOC in the analyzed expiratory gas.Type: ApplicationFiled: March 7, 2013Publication date: January 30, 2014Applicants: NIHON KOHDEN CORPORATION, TOKAI UNIVERSITY EDUCATIONAL SYSTEM, WASEDA UNIVERSITYInventors: Muneshige KURAHASHI, Naofumi Kobayashi, Sunao Takeda, Takashi Nagaoka, Tadashi Abe, Tetsuya Urano, Takuya Aoki, Chizuko Tsuji
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Patent number: D747474Type: GrantFiled: September 19, 2014Date of Patent: January 12, 2016Assignees: ASAHI INTECC CO., LTD., TOKAI UNIVERSITY EDUCATIONAL SYSTEMInventors: Jun Koizumi, Masaaki Nihonmatsu, Yukiko Enami
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Patent number: D755373Type: GrantFiled: September 19, 2014Date of Patent: May 3, 2016Assignees: ASAHI INTECC CO., LTD., TOKAI UNIVERSITY EDUCATIONAL SYSTEMInventors: Jun Koizumi, Masaaki Nihonmatsu, Yukiko Enami