Patents Assigned to Tomita Pharmaceuticals Co., Ltd.
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Patent number: 11866611Abstract: The purpose of the present invention is to provide a plasma spray material which is capable of forming a hydroxyapatite film that exhibits high adhesion strength with respect to substrates such as metal substrates. When used as a plasma spray material, hydroxyapatite powder having a modal diameter of 550-1000 nm in a pore diameter of at most 5000 nm as measured by a mercury intrusion method is capable of forming a hydroxyapatite film that exhibits high adhesion strength with respect to substrates such as metal substrates.Type: GrantFiled: December 6, 2018Date of Patent: January 9, 2024Assignee: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Naoyuki Kitamura, Akihito Bando, Yuta Tsumura, Shota Minami
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Patent number: 11124420Abstract: Provided is powdered gyrolite-type calcium silicate that has a relatively large particle size, yet is endowed with both a high oil absorption and a high particle strength. The powdered gyrolite-type calcium silicate has (1) an oil absorption of at least 2.8 mL/g, (2) an average particle diameter of at least 40 ?m, and (3) in treatment where the gyrolite-type calcium silicate is charged into a laser diffraction-type particle size analyzer within the range of a diffraction volume of from 0.1 to 0.6 and circulated at a flow rate of 32.5 mL/s for 5 minutes, a percent change in average particle diameter following treatment with respect to average particle diameter before treatment of 15% or less.Type: GrantFiled: November 7, 2014Date of Patent: September 21, 2021Assignee: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Yuuta Tsumura, Kazuki Kamai, Yukinori Konishi, Kazuhiko Tamagawa
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Patent number: 10793696Abstract: An object of the present invention is to provide a polyolefin composition prepared by kneading a hygroscopic inorganic filler into a polyolefin, without substantially using an additive such as a dispersant or an antioxidant, the polyolefin composition having good dispersibility of the hygroscopic inorganic filler as well as excellent moldability. By kneading anhydrous magnesium sulfate as a hygroscopic inorganic filler into a polyolefin, without substantially adding an additive such as a dispersant or an antioxidant, and by setting the moisture content in the kneaded product to 0.1 wt % or less, a polyolefin composition having good dispersibility of anhydrous magnesium sulfate as well as excellent moldability can be obtained.Type: GrantFiled: January 19, 2016Date of Patent: October 6, 2020Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Hideyuki Aoyama, Yoshiyasu Bando, Masanori Sumi, Masaya Uemoto, Makoto Fujii, Seiji Sato
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Patent number: 10531684Abstract: Provided is a powder containing ferric pyrophosphate that affords high iron absorbability, as a main component of an oral iron preparation. The present invention relates to a composite powder containing ferric pyrophosphate, which is a powder containing ferric pyrophosphate and a sodium component, wherein (1) the content of ferric pyrophosphate is 95 wt % or higher, and (2) a (Fe+Na)/P molar ratio is 0.8 to 1.0.Type: GrantFiled: December 10, 2015Date of Patent: January 14, 2020Assignee: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Sadayoshi Watanabe, Yukinori Konishi, Shota Minami, Akihito Bando, Naoyuki Kitamura
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Patent number: 10525078Abstract: A solid dialysis A agent is provided, which is to be used in preparing a bicarbonate dialysis fluid, wherein: the solid dialysis A agent contains glucose, acetic acid and an acetate salt; at least a part of a mixture of the acetic acid with the acetate salt is an alkali metal diacetate; and the acetic acid/acetate salt molar ratio is adjusted to 1/0.5 to 1/2. This solid dialysis A agent makes it possible to prepare a bicarbonate dialysis fluid which has a total acetate ion concentration of 2 to less than 6 mEq/L. Further, the dialysis A agent exhibits excellent stability of ingredients and a reduced acetic acid odor.Type: GrantFiled: October 2, 2014Date of Patent: January 7, 2020Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Michiko Myose, Hiroshi Noguchi, Junya Kikuishi, Hideyuki Aoyama, Mina Hashimoto, Yusuke Yoshimoto
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Patent number: 10517825Abstract: Provided is a powder composition containing an oily substance, the powder composition having good oxidation stability and excellent compression moldability. The powder composition containing an oily substance contains a powdery calcium silicate-based material, and an oily substance impregnated into the material. In the material, a cumulative pore volume for a pore size of 10 to 70 nm is 1.1 cc/g or more, and a cumulative pore volume for a pore size of 70 to 500 nm is 2.0 cc/g or less.Type: GrantFiled: May 27, 2016Date of Patent: December 31, 2019Assignee: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Takanori Taniwaki, Kazuki Kamai, Yuuta Tsumura, Daichi Masaki
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Patent number: 10292913Abstract: Provided is a powdered tobermorite-type calcium silicate-based material capable of demonstrating high oil absorption. The powdered tobermorite-type calcium silicate-based material is characterized in that (1) a molar ratio of SiO2/CaO in the material is 1.5 or more, and (2) a cumulative pore volume having a pore size of 3.6 nm to 200 nm in the material is 0.9 cc/g or more, and a cumulative pore volume having a pore size of 3.6 nm to 5000 nm is 2.6 cc/g or more.Type: GrantFiled: March 26, 2015Date of Patent: May 21, 2019Assignee: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Yuka Okada, Kazuki Kamai, Yuuta Tsumura, Yukinori Konishi
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Patent number: 10251988Abstract: A dialysis agent A including a mixture containing glucose, acetic acid, and acetate salt, but not sodium bicarbonate, wherein the molar ratio of acetic acid:acetate salt is 1:0.5 to 1:2, and wherein a total amount of the acetic acid and acetate salt contained in the dialysis agent A is between 2 mEq/L and 6 mEq/L when the dialysis agent A is dissolved in 1 L of a bicarbonate dialysate.Type: GrantFiled: February 20, 2018Date of Patent: April 9, 2019Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Hiroshi Noguchi, Michiko Myose, Junya Kikuishi, Mina Hashimoto, Hideyuki Aoyama
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Publication number: 20180236433Abstract: A magnesium sulfate-based desiccant comprising powder composed of coated particles that contain a particle of magnesium sulfate represented by the chemical formula MgSO4.nH2O (0?n?3) and a coating layer on the surface of the particle, wherein: (1) the coating layer contains a coating material that is at least one of carboxylic acids and salts thereof; (2) the powder has an average particle diameter of 5 ?m or less; and (3) a contact angle of water relative to the face formed with the powder is 20 degrees or more, and to a method for producing the same.Type: ApplicationFiled: April 23, 2018Publication date: August 23, 2018Applicant: Tomita Pharmaceutical Co., Ltd.Inventors: Kazuhito Kayama, Koh Konishi, Masahiro Hitomi, Minoru Kometani, Masashi Konishi, Ariumi Kawamoto
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Patent number: 9931453Abstract: The purpose of the present invention is to provide a dialysis agent A, which is able to set the total acetate ion content in the dialysate to a low value, excellent in storage stability of glucose, able to reduce the acetic acid odor, and able to suppress the corrosion of the dialysate delivery system and the dialysis machine, as well as to provide a two pack type dialysis agent utilizing the dialysis agent A. In the dialysis agent A used in the preparation of a bicarbonate dialysate, which is used as one part of a two pack type dialysis agent, it becomes possible to prepare a bicarbonate dialysate having the total acetate ion concentration of between 2 mEq/L or more and less than 6 mEq/L by allowing to include glucose, acetic acid and acetate salt and to satisfy the molar ratio of 1:0.5 to 2 of acetic acid and acetate salt, and include acetic acid and acetate salt in a total amount of between 2 mEq or more and less than 6 mEq in the dialysis agent A required to prepare 1 L of the bicarbonate dialysate.Type: GrantFiled: October 9, 2013Date of Patent: April 3, 2018Assignee: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Hiroshi Noguchi, Michiko Myose, Junya Kikuishi, Mina Hashimoto, Hideyuki Aoyama
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Patent number: 9463266Abstract: Technology for preparing a dialysis fluid capable of flexibly changing bicarbonate ion concentration and maintaining concentrations of electrolytes such as potassium, calcium, and magnesium at constant levels during dialysis according to the disease state of a patient. A three-component dialysate containing an agent S containing sodium chloride, an agent B containing sodium bicarbonate, and an agent A containing electrolyte components other than sodium chloride and sodium bicarbonate, with suitable adjustment of the amount of the agent B during dialysis fluid preparation maintains concentrations of trace metal ions such as potassium ions, calcium ions, and magnesium ions in a dialysis fluid at constant levels and flexibly changes the bicarbonate ion concentration therein. Adjusting the ratio between the amount of the agent S and agent B when the dialysate is used also makes it possible to maintain the sodium ion concentration at a constant level or flexibly change the sodium ion concentration.Type: GrantFiled: December 27, 2012Date of Patent: October 11, 2016Assignee: Tomita Pharmaceuticals Co., Ltd.Inventors: Hiroshi Noguchi, Junya Kikuishi, Hideyuki Aoyama, Mina Hashimoto
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Patent number: 9149434Abstract: The present invention provides a core particle for a pharmaceutical preparation which features the requisite properties of a core particle, and which has enough chemical stability, and in which reactivity with the drug (an active pharmaceutical ingredient) is limited or prevented. More specifically, the present invention relates to a core particle wherein a film containing an active pharmaceutical ingredient can be formed on the surface thereof, and (1) the core particle comprises a pharmaceutically acceptable inorganic material, (2) the inorganic material is poorly soluble in water, and (3) pH of a solution of the inorganic material is 5 to 8.Type: GrantFiled: September 8, 2008Date of Patent: October 6, 2015Assignee: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Masashi Konishi, Shouichi Oonishi, Akira Ookubo, Masashi Yunoki, Ariumi Kawamoto, Kanako Hattori
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Patent number: 8980330Abstract: Provided is a method that enables a calcium silicate-based material to be produced more efficiently. The method of producing a calcium silicate-based material comprises: (1) a step of obtaining a reaction product by reacting raw materials containing a calcium component, a silicon component and an aluminum component in an aqueous medium; and (2) a step of forming calcium silicate by subjecting the reaction product to hydrothermal treatment.Type: GrantFiled: February 27, 2013Date of Patent: March 17, 2015Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Koh Konishi, Yuta Tsumura, Seiki Shinomiya, Masashi Konishi, Yukinori Konishi
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Publication number: 20140171571Abstract: The present invention is to provide a magnesium sulfate-based desiccant comprising powder composed of coated particles that contain a particle of magnesium sulfate represented by the chemical formula MgSO4.nH2O (0?n?3) and a coating layer on the surface of the particle, wherein: (1) the coating layer contains a coating material that is at least one of carboxylic acids and salts thereof; (2) the powder has an average particle diameter of 5 ?m or less; and (3) a contact angle of water relative to the face formed with the powder is 20 degrees or more, and to a method for producing the same.Type: ApplicationFiled: July 13, 2012Publication date: June 19, 2014Applicant: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Kazuhito Kayama, Koh Konishi, Masahiro Hitomi, Minoru Kometani, Masashi Konishi, Ariumi Kawamoto
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Publication number: 20140097386Abstract: The purpose of the present invention is to provide a dialysis agent A, which is able to set the total acetate ion content in the dialysate to a low value, excellent in storage stability of glucose, able to reduce the acetic acid odor, and able to suppress the corrosion of the dialysate delivery system and the dialysis machine, as well as to provide a two pack type dialysis agent utilizing the dialysis agent A. In the dialysis agent A used in the preparation of a bicarbonate dialysate, which is used as one part of a two pack type dialysis agent, it becomes possible to prepare a bicarbonate dialysate having the total acetate ion concentration of between 2 mEq/L or more and less than 6 mEq/L by allowing to include glucose, acetic acid and acetate salt and to satisfy the molar ratio of 1:0.5 to 2 of acetic acid and acetate salt, and include acetic acid and acetate salt in a total amount of between 2 mEq or more and less than 6 mEq in the dialysis agent A required to prepare 1 L of the bicarbonate dialysate.Type: ApplicationFiled: October 9, 2013Publication date: April 10, 2014Applicant: Tomita Pharmaceutical Co., Ltd.,Inventors: Hiroshi NOGUCHI, Michiko MYOSE, Junya KIKUISHI, Mina HASHIMOTO, Hideyuki AOYAMA
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Patent number: 8679547Abstract: Provided is a method that enables a calcium silicate-based material to be produced more efficiently. The method of producing a calcium silicate-based material comprises: (1) a step of obtaining a reaction product by reacting raw materials containing a calcium component, a silicon component and an aluminum component in an aqueous medium; and (2) a step of forming calcium silicate by subjecting the reaction product to hydrothermal treatment.Type: GrantFiled: October 20, 2011Date of Patent: March 25, 2014Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Koh Konishi, Yuta Tsumura, Seiki Shinomiya, Masashi Konishi, Yukinori Konishi
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Patent number: 8668852Abstract: The present invention provides a powder for molding that reduces or prevents drawbacks such as unevenness and low fluidity when a mixed powder is used as a powder for molding. The present invention relates to powders for molding including particles in which each particle contains an inorganic component and a water-soluble organic polymer component and methods for producing the same.Type: GrantFiled: February 26, 2010Date of Patent: March 11, 2014Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Akira Ookubo, Tomohide Koizumi, Kazuma Tamura
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Publication number: 20130171270Abstract: Provided is a method that enables a calcium silicate-based material to be produced more efficiently. The method of producing a calcium silicate-based material comprises: (1) a step of obtaining a reaction product by reacting raw materials containing a calcium component, a silicon component and an aluminum component in an aqueous medium; and (2) a step of forming calcium silicate by subjecting the reaction product to hydrothermal treatment.Type: ApplicationFiled: February 27, 2013Publication date: July 4, 2013Applicant: TOMITA PHARMACEUTICAL CO., LTD.Inventor: Tomita Pharmaceutical Co., Ltd.
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Publication number: 20130168316Abstract: Technology for preparing a dialysis fluid capable of flexibly changing bicarbonate ion concentration and maintaining concentrations of electrolytes such as potassium, calcium, and magnesium at constant levels during dialysis according to the disease state of a patient. A three-component dialysate containing an agent S containing sodium chloride, an agent B containing sodium bicarbonate, and an agent A containing electrolyte components other than sodium chloride and sodium bicarbonate, with suitable adjustment of the amount of the agent B during dialysis fluid preparation maintains concentrations of trace metal ions such as potassium ions, calcium ions, and magnesium ions in a dialysis fluid at constant levels and flexibly changes the bicarbonate ion concentration therein. Adjusting the ratio between the amount of the agent S and agent B when the dialysate is used also makes it possible to maintain the sodium ion concentration at a constant level or flexibly change the sodium ion concentration.Type: ApplicationFiled: December 27, 2012Publication date: July 4, 2013Applicant: TOMITA PHARMACEUTICAL CO., LTD.Inventor: TOMITA PHARMACEUTICAL CO., LTD.
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Publication number: 20130101685Abstract: Provided is a method that enables a calcium silicate-based material to be produced more efficiently. The method of producing a calcium silicate-based material comprises: (1) a step of obtaining a reaction product by reacting raw materials containing a calcium component, a silicon component and an aluminum component in an aqueous medium; and (2) a step of forming calcium silicate by subjecting the reaction product to hydrothermal treatment.Type: ApplicationFiled: October 20, 2011Publication date: April 25, 2013Applicant: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Koh Konishi, Yuta Tsumura, Seiki Shinomiya, Masashi Konishi, Yukinori Konishi