Patents Assigned to TOMOCUBE, INC.
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Publication number: 20230410256Abstract: The present disclosure provides a system and method for improving image resolution of a three-dimensional (3-D) refractive index microscope based on an artificial intelligence (AI) technology. The present disclosure provides a technology for converting a low-resolution 3-D refractive index microscope image into a high-resolution 3-D refractive index image without physical machine conversion and re-photographing based on AI. That is, the present disclosure applies an AI technology, such as deep learning, in order to train an AI model with a physical correlation between a low-resolution 3-D refractive index microscope image and a high-resolution 3-D refractive index image of various samples, such as a cell and a tissue, and convert a low resolution image into a high resolution image without a change in a physical microscope based on the training. Furthermore, for the training of the AI model, the present disclosure uses physical characteristics of a refractive index image.Type: ApplicationFiled: August 11, 2022Publication date: December 21, 2023Applicant: Tomocube, Inc.Inventors: Hyunseok MIN, Dongmin RYU, Woonsoo LEE, Hansol YOON
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Patent number: 11821834Abstract: A method and apparatus for measuring a 3-D refractive index tensor are presented. The method for measuring a 3-D refractive index tensor according to an embodiment comprises the steps of: controlling incident light of a plane wave with respect to at least one angle and polarization; and measuring, in a polarization-dependent manner, the 2-D diffracted light of a specimen with respect to the incident light incident at the at least one angle and polarization, wherein the birefringence value and the 3-D structure of an alignment direction of molecules in the specimen having birefringence may be measured.Type: GrantFiled: January 7, 2021Date of Patent: November 21, 2023Assignees: TOMOCUBE, INC., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Yongkeun Park, Seungwoo Shin
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Patent number: 11450062Abstract: Disclosed are a method and apparatus for generating a three-dimensional (3-D) molecular image based on a label-free method using a 3-D refractive index image and deep learning. The apparatus for generating a 3-D molecular image based on a label-free method using a 3-D refractive index image and deep learning may include a 3-D refractive index cell image measurement unit configured to measure a 3-D refractive index image of a cell to be monitored and a 3-D refractive index and fluorescence molecule staining image conversion unit configured to input a measured value of the 3-D refractive index image to a deep learning algorithm and to output a 3-D fluorescence molecule staining cell image of the cell.Type: GrantFiled: March 19, 2020Date of Patent: September 20, 2022Assignees: Tomocube, Inc., Korea Advanced Institute of Science and TechnologyInventors: YongKeun Park, Weisun Park, Youngju Jo, Hyunseok Min, Hyungjoo Cho
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Patent number: 11408725Abstract: Proposed are a three-dimensional (3D) optical tomography method and apparatus using a partially coherent light and a multi-illumination pattern. The 3D optical diffraction tomography method based on low coherence light and a multi-illumination pattern using a 3D optical diffraction tomography apparatus may include making light incident on a sample using a plurality of patterns, measuring, by an image measurement unit, different locations at different depth locations of the sample and measuring two-dimensional (2D) images of the sample, and reconstructing 3D refractive index information of the sample based on the different patterns and the 2D images obtained at the different depth locations.Type: GrantFiled: September 17, 2020Date of Patent: August 9, 2022Assignee: Tomocube, Inc.Inventors: YongKeun Park, Herve Jerome Hugonnet
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Patent number: 11410304Abstract: A non-label diagnosis apparatus for a hematologic malignancy may include a 3-D refractive index cell imaging unit configured to generate a 3-D refractive index slide image of a blood smear specimen by capturing a 3-D refractive index image in the form of the blood smear specimen in which blood (including a bone-marrow or other body fluids) of a patient has been smeared on a slide glass, an ROI detection unit configured to sample a suspected cell segment in the blood smear specimen based on the 3-D refractive index slide image and to determine, as ROI patches, cells determined as abnormal cells, and a diagnosis unit configured to determine a sub-classification of a cancer cell corresponding to each of the ROI patches using a cancer cell sub-classification determination model constructed based on a deep learning algorithm and to generate hematologic malignancy diagnosis results by gathering sub-classification results of the ROI patches.Type: GrantFiled: June 12, 2020Date of Patent: August 9, 2022Assignee: TOMOCUBE, INC.Inventors: YongKeun Park, Donghun Ryu, Young Seo Kim, Kihyun Hong, Hyun-Seok Min
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Patent number: 10976532Abstract: Presented are a structured illumination microscopy system using a digital micromirror device and a time-complex structured illumination, and an operation method therefor. A structured illumination microscopy system using a digital micromirror device and a time-complex structured illumination according to an embodiment may comprise: a light source; a digital micromirror device (DMD) for receiving light irradiated from the light source, implementing a time-complex structured illumination, and causing a controlled structured illumination to enter a sample; and a fluorescence image measurement unit for extracting a high-resolution 3D fluorescence image of the sample.Type: GrantFiled: June 9, 2017Date of Patent: April 13, 2021Assignees: Tomocube, Inc., Korea Advanced Institute of Science and TechnologyInventor: YongKeun Park
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Publication number: 20200394794Abstract: A non-label diagnosis apparatus for a hematologic malignancy may include a 3-D refractive index cell imaging unit configured to generate a 3-D refractive index slide image of a blood smear specimen by capturing a 3-D refractive index image in the form of the blood smear specimen in which blood (including a bone-marrow or other body fluids) of a patent has been smeared on a slide glass, an ROI detection unit configured to sample a suspected cell segment in the blood smear specimen based on the 3-D refractive index slide image and to determine, as ROI patches, cells determined as abnormal cells, and a diagnosis unit configured to determine a sub-classification of a cancer cell corresponding to each of the ROI patches using a cancer cell sub-classification determination model constructed based on a deep learning algorithm and to generate hematologic malignancy diagnosis results by gathering sub-classification results of the ROI patches.Type: ApplicationFiled: June 12, 2020Publication date: December 17, 2020Applicants: TOMOCUBE, INC., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: YongKeun PARK, Donghun RYU, Young Seo KIM, Kihyun HONG, Hyun-Seok MIN
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Patent number: 10215697Abstract: A method and apparatus for measuring 3D refractive-index tomograms using a wavefront shaper in ultra-high speed and high precision is provided. The method includes the steps of modifying at least one of an illumination angle and a wavefront pattern of an incident ray through the wavefront shaper and leading the modified incident ray to a sample, measuring a 2D optical field, which passes through the sample, through an interferometry along at least one or more of the incident rays, and obtaining 3D refractive-index tomograms through measured information of the 2D optical field.Type: GrantFiled: December 28, 2015Date of Patent: February 26, 2019Assignee: TOMOCUBE, INC.Inventors: YongKeun Park, Kyoohyun Kim, Seungwoo Shin
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Patent number: 10082662Abstract: An ultra-high-speed 3D refractive index tomography and structured illumination microscopy system using a wavefront shaper and a method using the same are provided. A method of using an ultra-high-speed 3D refractive index tomography and structured illumination microscopy system that utilizes a wavefront shaper includes adjusting an irradiation angle of a plane wave incident on a sample by using the wavefront shaper, measuring a 2D optical field, which passes through the sample, based on the irradiation angle of the plane wave, and obtaining a 3D refractive index image from information of the measured 2D optical field by using an optical diffraction tomography or a filtered back projection algorithm.Type: GrantFiled: August 22, 2016Date of Patent: September 25, 2018Assignees: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, TOMOCUBE, INC.Inventors: YongKeun Park, Seungwoo Shin, Gwang Sik Park