Abstract: To provide a method for manufacturing a module having a selectively permeable membrane wherein the surface of the selectively permeable membrane thereof can be washed with good efficiency and further contaminants having been exfoliated from the surface of the membrane by a washing operation can be discharged from the inside of a housing with good efficiency; and the above module having a selectively permeable membrane. A module wherein a selectively permeable membrane is held in a housing and both ends of the above selectively permeable membrane are fixed, the both ends of the above selectively permeable membrane are fixed to an upper holder and an under holder connected by at least one washing tube, and then, the membrane is held in the housing; and a module having a selectively permeable membrane manufactured by the above manufacturing method.

Abstract: The present invention provides a hollow fiber membrane where the membrane strength and pressure resistance to pressurization from the dialysate side is ensured, the retaining rate of water permeability after the repeated pressure load from outside is high, the resistance to the pressure from outside is excellent and the assembling property into module (low leakage rate at the adhered part) is satisfactory at the same time. The present invention also provides a method for manufacturing the same, and a blood purification module. An annealing spinning method was found where a spinning dope is discharged from a nozzle into a coagulation bath, an appropriate elongation is applied so as to enhance the membrane strength, an elongation is continued during a water-washing step so as not to relax the elongation, and no elongation is applied during drying whereby the strain is relaxed.

Abstract: The present invention provides a nerve regeneration-inducing tube in which collagen having excellent adhesive property, cell growth property and differentiation inducing property to nerve cells is used as a scaffold for the nerve regeneration. The nerve regeneration-inducing tube is characterized in using the collagen which is made the concentration of sodium chloride contained therein not more than 2.0% by weight or, preferably, 0.1 to 1.5% by weight in a dry state. Purification of collagen is carried out by means of an isoelectric precipitation where the pH is 6.0 or higher and is lower than 10.0.

Abstract: The problem to be solved by the present invention is to provide a biaxially oriented polyamide based mixed resin film roll with which bag forming processing by lamination is able to be performed smoothly and with high yield ratio and at the same time with which packages free of S-shaped curls can be obtained efficiently. A solution for the problem concerns the polyamide based mixed resin film roll of the present invention which includes a first sample cutout portion within 2 m from the winding end of film and a final cutout portion within 2 m from the winding start of film, and when a sample cutout portion is set up in approximately every 100 m from the first sample cutout portion, in all samples cut out from each of the cutout portions, physical properties such as elastomer content, elastic modulus in tension, boiling water shrinkage percentage and refraction index in the thickness direction are adjusted to be within a predetermined range of variation range.

Abstract: The present invention provides an expression vector which is effective in an efficient establishment of transformed cells which express the aimed protein gene in a high level. An expression vector which has a cassette for expressing the drug selective marker gene containing mRNA destabilizing sequence, at least one element for stabilizing the gene expression and a cassette for expressing the gene of the aimed protein. Preferably, the mRNA destabilizing sequence is derived from AT-rich sequence existing in the 3?-untranslated region of cytokine, interleukin or proto-oncogene, and the element for stabilizing the gene expression is derived from Chinese hamster genome.

Abstract: The invention relates to plants and their progeny with improved morphogenesis in a variety of organs; to a method for producing the plants; and to a method for producing calli.

Abstract: The purpose of the present invention is to provide a porous hollow fiber membrane that can efficiently separate and remove the substances to be removed such as small-particle virus contained in a solution and, at the same time, useful recovering substances such as protein can be efficiently permeated and the decrease of its transmission rate with elapse of time is small. The porous hollow fiber membrane of the present invention is characterized in that the filtration downstream surface thereof has dot-shaped or slit-shaped pores, the filtration upstream surface thereof is a network structure or a fine particle aggregate structure, the central region of the membrane is composed of a substantially homogeneous structure, the membrane wall is composed of a structure having substantially no macrovoids, the permeability for pure water is 10 to 300 L/(h·m2·bar) and the permeability for a 0.1% by weight solution of bovine ?-globulin is 30 to 100% of the permeability for pure water.

Abstract: [Problem] Provision of a heat-sealable multilayer polypropylene-based resin film having heat seal strength sufficient for packaging a heavy article and tight-sealing property, and a packaging material using the film. [Solving means] A heat-sealable multilayer polypropylene-based resin film comprising a crystalline polypropylene-based resin and a propylene-?-olefin copolymer, which is an oriented polypropylene-based resin film made of a laminate of 3 or more layers of a substrate layer having a melting point of 155° C. or less, an intermediate layer and a thermal adhesion layer having a melting point of 150° C. or less, wherein the intermediate layer has a xylene-soluble content of 2.5% or less, the substrate layer has a melting point higher than that of the intermediate layer, and the intermediate layer has a thickness of 4 ?m or above.

Abstract: The present invention relates to a cosmetic for skin roughness improvement/skin care containing a biosurfactant, particularly MEL-A, MEL-B or MEL-C.

Abstract: The invention provides a modified flavin adenine dinucleotide dependent glucose dehydrogenase (FADGDH), as well as a glucose sensor comprising the modified FADGDH and a method for measuring glucose comprising using the glucose sensor to measure glucose of a sample.

Abstract: The present invention provides a L-succinylacylase consisting of: (a) a protein coded by a gene consisting of a nucleic acid sequence shown in SEQ ID No: 1; (b) a protein consisting of an amino acid sequence shown in SEQ ID No: 2; (c) a protein coded by a polynucleotide which hybridizes under a stringent condition with a nucleic acid sequence which is complementary to the nucleic acid sequence shown in SEQ ID No: 1 and having an L-succinylaminoacylase activity; or (d) a protein which consists of an amino acid sequence where one or several amino acid(s) is/are substituted, deleted, inserted and/or added in the protein consisting of the amino acid sequence shown in SEQ ID No: 2 and has an L-succinylaminoacylase activity. This enzyme is able to produce a sterically bulky unnatural amino acid such as L-tert-leucine etc. which is useful as an intermediate for pharmaceuticals.

Abstract: The present invention provides an L-aminoacylase which is able to produce L-tert-leucine being useful as an intermediate for pharmaceuticals. A protein which is characterized in being represented by any of the following (a) to (d): (a) a protein coded by a gene consisting of a nucleic acid sequence shown in SEQ ID No: 1; (b) a protein consisting of an amino acid sequence shown in SEQ ID No: 2; (c) a protein coded by a polynucleotide which hybridizes under a stringent condition with a nucleic acid sequence which is complementary to the nucleic acid sequence shown in SEQ ID No: 1 and having an L-succinylaminoacylase activity; and (d) a protein which consists of an amino acid sequence where one or several amino acid (s) is/are substituted, deleted, inserted and/or added in the protein consisting of the amino acid sequence shown in SEQ ID No: 2 and has an L-succinylaminoacylase activity.

Abstract: The present invention is a process for producing a polyester-polycarbonate type thermoplastic polyester elastomer in which a hard segment consisting of a polyester constructed of aromatic dicarboxylic acid, and an aliphatic or alicyclic diol, and a soft segment consisting mainly of aliphatic polycarbonate are connected, comprising at least a step of increasing the molecular weight of an aliphatic polycarbonate diol by a reaction of an aliphatic polycarbonate diol and a chain extender, and a step of reacting aliphatic polycarbonate and a polyester constructed of aromatic dicarboxylic acid and an aliphatic or alicyclic diol in the molten state.

Abstract: [Object] An object of the present invention is to provide, for the purpose of preventing or suppressing stress at a cellular level, a composition containing a plant-derived polyamine-containing extract that has a stress-reducing action, an anti-stress action, a stress-suppressing action, a stress-preventing action, a stress-inhibiting action, a stress protective action, or the like. Another object of the present invention is to provide cosmetics, quasi drugs, medical supplies, sanitary goods, pharmaceuticals, foods, or drinks that each contain such a composition. [Solution] A stress-reducing agent including a plant-derived polyamine-containing extract serving as an active component is provided.

Abstract: Disclosed is a polyamide resin film which has excellent dimensional stability with respect to moisture absorption, excellent mechanical characteristics and sliding properties under high temperature and high humidity conditions, and excellent handling properties. Specifically disclosed is a biaxially stretched polyamide resin film, to which 0.3-10% by weight of an inorganic material including a layered compound is added. The biaxially stretched polyamide resin film is characterized in that the layered compound is in-plane oriented, and that the film has a haze of 1.0-20%, an elastic modulus in the longitudinal direction of 1.7-3.5 GPa at a relative humidity (RH) of 35%, a surface roughness (Sa) of 0.01-0.1 ?m, and a coefficient of static friction (F/B) of 0.3-1.0 at a normal stress of 0.5 N/cm2.

Abstract: It is intended to provide by improving a known method of producing hyaluronic acid in a plant, a plant or a cultured plant cells which can produce hyaluronic acid at a lower cost and a further higher yield than before, a method of preparing the same, an expression vector for transformation, a method of producing hyaluronic acid using the plant or the cultured plant cells and the like. The method of producing hyaluronic acid comprising obtaining hyaluronic acid by co-expressing a protein with hyaluronic acid synthase activity and an exogenous protein with sugar-nucleotide synthase activity in a plant cell or a plant is provided.

Abstract: The present invention provides: a protein having a fructosyl amino acid oxidase activity which protein is useful for measurement of a glycosylated protein (particularly, glycosylated hemoglobin); a modified protein thereof; and use of the protein or the modified protein. The protein of the present invention is, for example, a fructosyl valyl histidine oxidase derived from Phaeosphaeria nodorum, the fructosyl valyl histidine oxidase having excellent thermal stability and substrate specificity and also having a small Km value to fructosyl valyl histidine. This allows a glycosylated protein measuring reagent to be stored in a long time and measurement accuracy of the glycosylated protein measuring reagent to be improved.

Abstract: A fabric for an airbag includes a synthetic fiber woven fabric in which at least one side thereof is coated with a synthetic resin. A range of 0.1 to 10 g/m2 of the synthetic resin is adhered to the synthetic fiber woven fabric having a cover factor of less than 2000 and a FR value of 55% or more. Air permeability of the fabric under a pressure difference of 100 kPa after adhesion is 0.01 to 1.00 L/cm2/min. The synthetic resin can be a polyamide-based resin having a soft segment comprising a polyol with a number average molecular weight of 100 to 5000.

Abstract: A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.

Abstract: An object of the present invention is to provide a modifier which improves moldability in melt molding, particularly, injection molding, extrusion molding, profile molding, direct blow molding, or calendar processing molding using a polyester resin and, furthermore, which can improve mechanical physical property while maintaining transparency, and a polyester molded article using the modifier. The present invention relates to a modifier for a polyester resin, comprising an amorphous polyester resin (I), and a reactive compound (II) containing two or more glycidyl groups and/or isocyanate groups per one molecule and having a weight average molecular weight of not less than 200 and not more than 500 thousands.