Abstract: The tamper-evident closure is provided for a syringe with a Luer connection or a Luer lock connection, wherein at least the connection end consists of plastic. A cap which is connected to the syringe via at least one frangible web. The cap and the frangible web together with a fixation component are formed as one piece as a plastic injection molded part and are connected to the connection end of the syringe by way of welding.

Abstract: The syringe is a prefillable or prefilled syringe having a syringe cylinder which is delimited to one side by a plunger and which to the other side opens into a syringe connection having a free end closed by a membrane. The syringe cylinder, the syringe connection and the closing membrane are formed as one piece as a plastic injection molded part.

Abstract: Disclosed is a holder, attachable to a receptacle, with a hollow spike for piercing the membrane of the receptacle and with a connection piece arranged coaxially to the hollow spike for the releasable attachment of an injection syringe. For the quick and secure withdrawal of a liquid medicament from the receptacle whilst maintaining sterility demands the holder is formed as a closed-walled protective housing which accommodates the receptacle and which comprises a first housing part carrying the receptacle secured in position and a second housing part provided in its inside with the hollow spike and on the outside comprising the connection piece. The second housing part is coaxially movable relative to the first housing part between a position-secured initial position in which the hollow spike is distanced from the membrane and a working position in which the membrane is pierced through the hollow spike.