Patents Assigned to Triad National Security, LLC
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Patent number: 11802045Abstract: High temperature moderators for nuclear reactors and processes for their production are disclosed. The moderators include at least one hydrided metal and/or hydride metal allow, such as yttrium hydride, thorium hydride, yttrium-cerium hydride, yttrium-gadolinium hydride, yttrium calcium hydride, cerium hydride, etc. Such metal hydrides and/or hydride alloys may have high thermal stability, a relatively low thermal neutron absorption cross section, the ability to retain hydrogen over a large temperature range, and have good mechanical properties. Such moderators may induce spectral shift in reactors which, in turn, magnifies the Doppler reactivity temperature coefficient. Such moderators to thermalize neutrons may also enhance fuel utilization and cost-effectiveness of the reactor while keeping the core portable.Type: GrantFiled: May 29, 2020Date of Patent: October 31, 2023Assignee: TRIAD NATIONAL SECURITY, LLCInventors: Venkateswara Rao Dasari, Erik Luther, Dustin Cummins, Tarik Saleh, Joshua Taylor White, Joseph Wermer, Aditya Shivprasad, A.J. Fallgren
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Patent number: 11786597Abstract: The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of antibiotic resistant skin infections. In other embodiments, the compositions direct delivery within the skin. In still other embodiments, the compositions prevent transfer of substances through the stratum corneum. The disclosed compositions and methods can be tuned and modified such that they can be used to treat or prevent a variety of different diseases and disorders.Type: GrantFiled: June 21, 2019Date of Patent: October 17, 2023Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, TRIAD NATIONAL SECURITY, LLC, THE ARIZONA BOARD OF REGENTSInventors: Michael Zakrewsky, Samir Mitragotri, David T. Fox, Andrew Koppisch, Rico Del Sesto, Katherine Lovejoy
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Patent number: 11748657Abstract: Machine-learning methods and apparatus are provided to solve blind source separation problems with an unknown number of sources and having a signal propagation model with features such as wave-like propagation, medium-dependent velocity, attenuation, diffusion, and/or advection, between sources and sensors. In exemplary embodiments, multiple trials of non-negative matrix factorization are performed for a fixed number of sources, with selection criteria applied to determine successful trials. A semi-supervised clustering procedure is applied to trial results, and the clustering results are evaluated for robustness using measures for reconstruction quality and cluster separation. The number of sources is determined by comparing these measures for different trial numbers of sources. Source locations and parameters of the signal propagation model can also be determined.Type: GrantFiled: September 14, 2020Date of Patent: September 5, 2023Assignee: Triad National Security, LLCInventors: Boian S. Alexandrov, Ludmil B. Alexandrov, Filip L. Iliev, Valentin G. Stanev, Velimir V. Vesselinov
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Patent number: 11750677Abstract: Techniques for framing data in various data transmission contexts are described. A data framing technique may include a transmitter sending a data stream including repeating bits in alternating forward and reverse order. A receiver of the data stream may fold the data stream, and correlate portions of the folded data stream for purposes of validating the data stream and/or identifying an ID in the data stream. In at least some instances, once the receiver validates the data stream, the receiver may accept payload accompanying the data stream.Type: GrantFiled: October 13, 2021Date of Patent: September 5, 2023Assignee: TRIAD NATIONAL SECURITY, LLCInventor: David Palmer
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Patent number: 11743049Abstract: Message authenticators for quantum-secured communications facilitate low-latency authentication with assurances of security. Low-latency message authenticators are especially valuable in infrastructure systems where security and latency constraints are difficult to satisfy with conventional non-quantum cryptography. For example, a message transmitter receives a message and derives an authentication tag for the message based at least in part on an authenticator that uses one or more quantum keys. The message transmitter outputs the message and its authentication tag. A message receiver receives a message and authentication tag for the message. The message receiver derives a comparison tag for the message based at least in part on an authenticator that uses one or more quantum keys. The message receiver checks whether the message is authentic based on a comparison of the authentication tag and the comparison tag. In example implementations, the authenticator uses stream-wise cyclic redundancy code operations.Type: GrantFiled: February 24, 2020Date of Patent: August 29, 2023Assignee: Triad National Security, LLCInventors: Richard J. Hughes, Jane E. Nordholt, Charles G. Peterson, Kush T. Tyagi, Christopher C. Wipf, Raymond T. Newell, Kevin P. McCabe, Nicholas Dallmann
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Patent number: 11739318Abstract: Biosensors including a nucleic acid encoding a PcaU protein, a PobR protein, a CatM protein, a PcaR protein, or a TphR protein are provided. In some examples, the biosensors include a promoter regulated by the sensed molecule operably linked to a reporter gene. The biosensors may be included in a vector or in cells including one or more of the biosensors or vectors. Modified chorismate pyruvate lyase (UbiC) and modified paraoxonase (PON1) proteins including one or more amino acid substitutions are provided. Finally, methods of selecting biocatalysts with increased activity including transforming a library of cells expressing a biosensor with one or more nucleic acids encoding one or more mutations in a gene involved in a biosynthesis pathway, determining activity of the reporter protein; and selecting a cell with increased reporter protein activity as expressing a biocatalyst with increased activity are provided.Type: GrantFiled: December 19, 2018Date of Patent: August 29, 2023Assignee: Triad National Security, LLCInventors: Ramesh K. Jha, Charlie E. Strauss, Taraka Dale
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Patent number: 11731989Abstract: Disclosed herein are embodiments of metal complexes and methods of making the same. The disclosed method embodiments provide a one-step approach to making metal complexes, such as complexes comprising lanthanide metals, rare earth metals, transition metals, main group metals, and/or actinide metals that can be used various applications, such as in separations technology, catalysis (e.g., catalysts for pharmaceutical synthesis and/or catalysts for biomass conversion), nuclear chemistry, LED phosphors, scintillator materials, magnetic materials, and nuclear fuels.Type: GrantFiled: July 11, 2019Date of Patent: August 22, 2023Assignee: Triad National Security, LLCInventors: Jaqueline Kiplinger, Ross Beattie, Justin Pagano, Karla Erickson
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Patent number: 11724306Abstract: Disclosed herein are embodiments of a coating composition for use in investment casting. The coating composition embodiments provide a solidified coat that can be as a mold for casting castable materials and that is easily removed from the casted material using water. The coating composition embodiments disclosed herein are reusable and are non-toxic and exhibit high thermal stability.Type: GrantFiled: June 25, 2021Date of Patent: August 15, 2023Assignee: Triad National Security, LLCInventors: Kyle Cluff, Matthew Lee
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Patent number: 11718598Abstract: The present disclosure relates to the selective hydrodeoxygenation (HDO) of bio-based furanic ketones with a bifunctional copper-based catalyst in the presence of a solvent to prepare alkyl furans with high yield, purity, and scalability. The alkyl furans prepared herein are useful in the preparation of surfactants.Type: GrantFiled: September 25, 2020Date of Patent: August 8, 2023Assignee: Triad National Security, LLCInventors: Andrew Sutton, Xiaokun Yang, Cameron M. Moore
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Patent number: 11714620Abstract: Decoupling loop dependencies using first in, first out (FIFO) buffers or other types of buffers to enable pipelining of loops is disclosed. By using buffers along with tailored ordering of their writes and reads, loop dependencies can be decoupled. This allows the loop to be pipelined and can lead to improved performance.Type: GrantFiled: January 14, 2022Date of Patent: August 1, 2023Assignee: Triad National Security, LLCInventors: Andrew John Dubois, Stephen Wayne Poole, Laura Marie Morton Monroe, Robert W. Robey, Brett R. Neuman
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Patent number: 11709093Abstract: System include an ultrasonic transducer configured to couple to a nondestructive testing (NDT) sample and configured to produce and direct an ultrasonic probe wave at a selected frequency into a subsurface region of the NDT sample, a 3D laser scanning vibrometer configured to direct a detection beam in a scan area on a surface of the NDT sample and to receive a return beam from the scan area, and to detect, based on the return beam, a 3D motion of the surface across a wideband frequency range, and a processor, and a memory configured with instructions that, when executed by the processor, cause the processor to produce sub-surface image data of the NDT sample at multiple harmonics of the selected frequency in the wideband frequency range based on the detected 3D surface motion, wherein the sub-surface image data describes a nonlinear defect response produced in the NDT sample by interaction of the ultrasonic probe wave with the subsurface region.Type: GrantFiled: September 28, 2020Date of Patent: July 25, 2023Assignees: Triad National Security, LLC, Tohoku UniversityInventors: Marcel Remillieux, Yoshikazu Ohara
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Patent number: 11708342Abstract: Disclosed herein are embodiments of a method for producing furfural from a hemicellulose source material. Also disclosed are embodiments of a system for carrying out the method. In particular embodiments, the method can be carried out without adding an extraneous mineral acid to facilitate pentose production from the hemicellulose source material and thus byproducts produced by the method can be used as animal feed.Type: GrantFiled: November 18, 2021Date of Patent: July 25, 2023Assignee: Triad National Security, LLCInventors: William L. Kubic, Jr., Xiaokun Yang
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Patent number: 11702465Abstract: Monoclonal antibodies that specifically bind the F1 antigen of Yersinia pestis with high affinity are described. Use of the monoclonal antibodies for the detection of Y. pestis infection and the diagnosis of plague are also described. Immunoconjugates of the monoclonal antibodies and a radionuclide can also be used for the treatment of a Y. pestis infection.Type: GrantFiled: September 25, 2020Date of Patent: July 18, 2023Assignee: Triad National Security, LLCInventors: Antonietta Maria Lillo, Nileena Velappan, Armand Earl Ko Dichosa, Stosh Anthony Kozimor, Laura Margaret Lilley
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Patent number: 11692930Abstract: A vibrometer may measure acoustic responses in portions of a structure along a scan path to acoustic excitation of the structure. A ranging device may measure distances to the portions of the structure along the scan path. A three-dimensional point cloud may be generated based on the acoustic responses in the portions of the structure and the distances to the portions of the structure. The three-dimensional point cloud may include points representing geometry of the portions of the structure. The points may be associated with the acoustic responses in corresponding portions of the structure. One or more properties of the structure may be determined based on an analysis of the three-dimensional point cloud.Type: GrantFiled: August 6, 2019Date of Patent: July 4, 2023Assignee: Triad National Security, LLCInventors: Eric Brian Flynn, Peter Hans Fickenwirth, Matthew James Adams
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Patent number: 11681059Abstract: A radiation detector includes a p-i-n architecture including a p-type contact layer, an n-type contact layer, and an intrinsic layer between the p-type contact layer and the n-type contact layer. The intrinsic layer includes a thin film comprising a highly crystalline 2D layered perovskite material. The radiation detectors according to embodiments of the present disclosure generate high open circuit voltages, have good detecting photon density limits and high sensitivities, and can be self-powered.Type: GrantFiled: September 29, 2021Date of Patent: June 20, 2023Assignee: TRIAD NATIONAL SECURITY, LLCInventors: Hsinhan Tsai, Wanyi Nie
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Patent number: 11680152Abstract: Disclosed herein are embodiments of a method for making recyclable polymers and a method for decomposing the polymers back to the monomers which can then be reused. The polymer are stable to aqueous and/or acid conditions and may have a formula II The method to decompose the polymer back to the monomers may comprise heating the polymer in a protic organic solvent.Type: GrantFiled: May 17, 2021Date of Patent: June 20, 2023Assignee: Triad National Security, LLCInventors: Andrew D. Sutton, Christopher David Roland, Cameron M. Moore
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Patent number: 11654424Abstract: The present disclosure is directed to method embodiments for making anhydrous lanthanide halide complexes. At least some embodiments comprise making a lanthanide halide complex by reacting a lanthanide metal oxide with an oxygen scavenger and catalyst in the presence of a donor solvent. The method is selective toward light lanthanide metal oxides and thus further provides a method for separating light lanthanide metal oxides from heavy lanthanide metal oxides, actinide oxides, and non-lanthanide rare earth element oxides.Type: GrantFiled: June 10, 2020Date of Patent: May 23, 2023Assignee: Triad National Security, LLCInventors: Jaqueline Loetsch Kiplinger, Louis A. Silks, Ross James Beattie
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Publication number: 20230150021Abstract: Processes for tailoring the macroscopic shape, metallic composition, mechanical properties, and pore structure of nanoporous metal foams prepared through combustion synthesis via direct write 3D printing of metal energetic ligand precursor inks made with water and an organic thickening agent are disclosed. Such processes enable production of never before obtainable metal structures with hierarchical porosity, tailorable from the millimeter size regime to the nanometer size regime. Structures produced by these processes have numerous applications including, but not limited to, catalysts, heat exchangers, low density structural materials, biomedical implants, hydrogen storage medium, fuel cells, and batteries.Type: ApplicationFiled: January 17, 2023Publication date: May 18, 2023Applicant: Triad National Security, LLCInventors: Bryce Tappan, Andrew Schmalzer, Alexander H. MUELLER
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Patent number: 11633806Abstract: A fill tool system that fills, seals, and inspects a heat pipe array, which includes one or more heat pipes with heat pipe working fluid.Type: GrantFiled: October 21, 2020Date of Patent: April 25, 2023Assignee: TRIAD NATIONAL SECURITY, LLCInventors: Robert S. Reid, Morgan T. Biel, Nicholas M. Diskerud, Lindsey M. Gaspar, Kyle B. Hammond, Martin Ward
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Patent number: 11628215Abstract: Provided herein are HIV-1 vaccines comprising a carrier and a population episensus antigen determined using the EpiGraph approach. Also provided are HIV-1 vaccines comprising a carrier, a population episensus antigen, and a tailored antigen. Also provided are methods of designing and producing an HIV-1 vaccine for a subject comprising designing vaccine antigens to optimally cover the diversity within a geographic area using an antigen amino acid sequence generated using the EpiGraph approach, and producing said designed vaccine antigen. Also provided are methods of inducing an effector memory T cell response comprising designing the one or more EpiGraph amino acid sequences, producing a vaccine comprising the one or more EpiGraph amino acid sequences and a vector, and administering the vaccine to a subject. Further provided are methods of treating HIV-1 in a subject comprising administering an effective amount of the described HIV-1 vaccines to the subject in need thereof.Type: GrantFiled: August 31, 2020Date of Patent: April 18, 2023Assignees: Vir Biotechnology, Inc., Triad National Security, LLC, Oregon Health & Science UniversityInventors: Eric Bruening, Klaus Frueh, Louis Picker, Bette T. M. Korber, James Theiler, Emily Marshall