Patents Assigned to Trifarma S.r.l.
  • Process for the preparation of 10-OXO-10, 11-dihydro-5H-dibenz (b,f) azepin-5-carboxamide
    Patent number: 5808058
    Abstract: A novel process for the preparation of 10-0.times.0-10,11-dihydro-5H-dibenz(b,f)azepin-5-carboxamide (VI) consists of starting group 10-methoxy-5H-dibenz(b,f)azepine (IV) and subjecting compound (IV) to direct carbamoylation with isocyanic acid generated in situ from cyanates and acids and then subjecting the product to acid hydrolysis of the enol ether. An alternative process to obtain (VI) starts (IV) effecting the hydrolysis reaction before the carbamoylation. In this case the carbamoylating agent is chlorosulfonyl isocyanate.
    Type: Grant
    Filed: December 24, 1996
    Date of Patent: September 15, 1998
    Assignee: Trifarma S.r.l.
    Inventor: Alberto Milanese