Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
Type:
Application
Filed:
September 14, 2023
Publication date:
May 2, 2024
Applicant:
TriLink Biotechnologies, LLC
Inventors:
Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7 Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
Type:
Grant
Filed:
November 6, 2020
Date of Patent:
January 23, 2024
Assignee:
TriLink BioTechnologies, LLC
Inventors:
Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
Type:
Grant
Filed:
May 26, 2022
Date of Patent:
February 14, 2023
Assignee:
TriLink Biotechnologies, LLC
Inventors:
Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
Type:
Application
Filed:
May 26, 2022
Publication date:
September 15, 2022
Applicant:
TriLink Biotechnologies, LLC
Inventors:
Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
Type:
Grant
Filed:
August 2, 2021
Date of Patent:
August 16, 2022
Assignee:
TriLink Biotechnologies, LLC
Inventors:
Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
Type:
Application
Filed:
August 2, 2021
Publication date:
December 2, 2021
Applicant:
TriLink Biotechnologies, LLC
Inventors:
Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7 Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
Type:
Application
Filed:
November 6, 2020
Publication date:
August 26, 2021
Applicant:
TriLink Biotechnologies, LLC
Inventors:
Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN