Abstract: Growth medium are disclosed for use in fermenting a marine microorganism. The medium comprise Potassium, Calcium, Strontium, Borate and Fluoride at specific concentrations. Alternatively, the growth medium comprises cobalt at specified concentrations or comprises vitamin B12 at specified concentrations. Methods of producing certain desired compound by fermentation of a marine microorganism are also disclosed.
Type:
Grant
Filed:
September 24, 2007
Date of Patent:
March 24, 2015
Assignee:
Triphase Research and Development I Corp.
Abstract: Disclosed herein are compositions and methods for treating neoplastic diseases. Included are compositions and methods that are effective against multiple myeloma cells resistant to conventional and bortezomib treatment. Furthermore, combination treatment with two different proteosome inhibitors is shown to be synergistic for treating multiple myeloma.
Type:
Application
Filed:
March 25, 2014
Publication date:
November 27, 2014
Applicants:
Dana-Farber Cancer Institute, Inc., Triphase Research and Development I Corp.
Inventors:
Kenneth C. Anderson, Dharminder Chauhan, Michael A. Palladino
Abstract: Disclosed herein are compositions and methods for treating neoplastic diseases. Included are compositions and methods that are effective against multiple myeloma cells resistant to conventional and bortezomib treatment. Furthermore, combination treatment with two different proteosome inhibitors is shown to be synergistic for treating multiple myeloma.
Type:
Grant
Filed:
July 30, 2008
Date of Patent:
May 13, 2014
Assignees:
Triphase Research and Development I Corp., Dana-Farber Cancer Institute, Inc.
Inventors:
Kenneth C. Anderson, Dharminder Chauhan, Michael A. Palladino