Patents Assigned to TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Unive
  • STABILIZATION OF POLY(A) SEQUENCE ENCODING DNA SEQUENCES
    Publication number: 20170166905
    Abstract: The present invention relates to nucleic acid molecules containing poly (dA:dT) regions which are stabilized in E. coli, methods of propagating such nucleic acid molecules in E. coli, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly (dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.
    Type: Application
    Filed: July 6, 2015
    Publication date: June 15, 2017
    Applicants: BioNTech RNA Pharmaceuticals GmbH, TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Unive
    Inventors: Florian EBERLE, Ugur SAHIN, Andreas KUHN, Britta VALLAZZA, Mustafa DIKEN