Patents Assigned to TrovaGene, Inc.
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Publication number: 20180087114Abstract: Provided is a method of determining responsiveness of a subject to a treatment for a cancer. Also provided is a method of determining treatment recommendations for a subject with cancer. Additionally provided is a method of treating a subject with cancer.Type: ApplicationFiled: March 4, 2016Publication date: March 29, 2018Applicant: Trovagene, Inc.Inventors: Vlada Melnikova, Mark G. Erlander
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Patent number: 9909118Abstract: This invention provides compositions and methods for rapid separation, isolation and purification of nucleic acids from biological samples using anionic exchange media. The method can utilize commercially available strong or weak anion exchanger materials with selected solutions of known ionic strength for adsorption and elution. The instant method is particularly advantageous as it permits the purification and identification of shorter fragments of nucleic acids from bodily fluids which, until now, had not been identified.Type: GrantFiled: April 30, 2015Date of Patent: March 6, 2018Assignee: Trovagene, Inc.Inventors: Samuil R Umansky, Hovsep S Melkonyan, Erik Meyer, William John Feaver
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Patent number: 9816148Abstract: The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids.Type: GrantFiled: August 6, 2015Date of Patent: November 14, 2017Assignee: Trovagene, Inc.Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Eugene M. Shekhtman
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Patent number: 9725767Abstract: The invention relates to new nucleophosmin protein (NPM) mutants, corresponding gene sequences and relative uses thereof for diagnosis, monitoring of minimal residual disease; prognostic evaluation and therapy of the acute myeloid leukaemia (AML).Type: GrantFiled: August 6, 2013Date of Patent: August 8, 2017Assignee: Trovagene, Inc.Inventors: Brunangelo Falini, Cristina Mecucci
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Patent number: 9725755Abstract: The present disclosure relates to the enrichment of target nucleic acid sequences present in low-abundance relative to corresponding non-target or reference nucleic acid sequence in a sample. In particular, the methods allow for a substantially greater level of detection sensitivity of target sequence by orders of magnitude enrichment of a low-abundance sequence.Type: GrantFiled: September 3, 2016Date of Patent: August 8, 2017Assignee: Trovagene, Inc.Inventors: Jason Poole, Saege Handcock, Karena Kosco, Vlada Melnikova, Peter Croucher, Tim Lu, Mark Erlander, Errin Samuelsz
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Publication number: 20170096661Abstract: Provided is a method for concentrating nucleic acids in urine which can be performed without use of toxic reagents and without centrifugation steps. The method allows a 10× or greater concentration of the nucleic acids, removes impurities, and allows processing of volumes greater than 20 ml as a single sample.Type: ApplicationFiled: October 20, 2016Publication date: April 6, 2017Applicant: TROVAGENE, INCInventors: Karena Kosco, Jason Poole, Mark G. Erlander
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Publication number: 20170016078Abstract: The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identifies individuals at risk of developing or in the early stages of cervical carcinoma.Type: ApplicationFiled: July 25, 2016Publication date: January 19, 2017Applicant: Trovagene, Inc.Inventors: Hovsep S. Melkonyan, Samuil R. Umansky, Zhenghan Xin
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Publication number: 20170009276Abstract: The present disclosure relates to the enrichment of target nucleic acid sequences present in low-abundance relative to corresponding non-target or reference nucleic acid sequence in a sample. In particular, the methods allow for a substantially greater level of detection sensitivity of target sequence by orders of magnitude enrichment of a low-abundance sequence.Type: ApplicationFiled: September 3, 2016Publication date: January 12, 2017Applicant: Trovagene, Inc.Inventors: Jason Poole, Saege Handcock, Karena Kosco, Vlada Melnikova, Peter Croucher, Tim Lu, Mark Erlander, Errin Samuelsz
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Patent number: 9453265Abstract: The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identifies individuals at risk of developing or in the early stages of cervical carcinoma.Type: GrantFiled: February 4, 2014Date of Patent: September 27, 2016Assignee: Trovagene, Inc.Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Zhenghan M. Xin
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Publication number: 20160115556Abstract: Provided is a method determining responsiveness to a treatment in a patient with a cancer.Type: ApplicationFiled: January 2, 2016Publication date: April 28, 2016Applicant: Trovagene, Inc.Inventors: Mark G. Erlander, Karena Kosco, Cecile Rose Vibat
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Publication number: 20160060717Abstract: The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids.Type: ApplicationFiled: May 20, 2013Publication date: March 3, 2016Applicant: TROVAGENE, INC.Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Eugene M. Shekhtman
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Patent number: 9222137Abstract: The present invention relates to hairy cell leukemia biomarkers and methods of utilizing these biomarkers to diagnose and/or treat hairy cell leukemia.Type: GrantFiled: May 10, 2012Date of Patent: December 29, 2015Assignee: Trovagene, Inc.Inventors: Enrico Tiacci, Brunangelo Falini, Raul Rabadan
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Publication number: 20150329920Abstract: The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids.Type: ApplicationFiled: August 6, 2015Publication date: November 19, 2015Applicant: TROVAGENE, INC.Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Eugene M. Shekhtman
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Patent number: 9163229Abstract: This invention provides compositions and methods for rapid isolation and purification of nucleopolymers from biological samples using anionic exchange media. The method of this invention can utilize commercially available anion exchanger materials with selected solutions of known ionic strength for absorption and elution. The medium/nucleoprotein bound complex may be optionally stored or transported, and is subsequently treated with eluents to remove undesirable proteins and inorganic salts. The partially purified complex may also be stored or transported. This method is particularly advantageous since it allows rapid isolation and purification of soluble nucleic acids from a large volume of biological fluids with easy handling and storage, stabilizing the samples against degradation prior to analysis. It also permits the purification and identification of shorter fragments of nucleic acids from bodily fluids which, until now, had not been identified.Type: GrantFiled: October 10, 2007Date of Patent: October 20, 2015Assignee: Trovagene, Inc.Inventors: Hovsep Melkonyan, Erik Meyer, William John Feaver, Samuil R. Umansky
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Publication number: 20150275198Abstract: This invention provides compositions and methods for rapid separation, isolation and purification of nucleic acids from biological samples using anionic exchange media. The method can utilize commercially available strong or weak anion exchanger materials with selected solutions of known ionic strength for adsorption and elution. The instant method is particularly advantageous as it permits the purification and identification of shorter fragments of nucleic acids from bodily fluids which, until now, had not been identified.Type: ApplicationFiled: April 30, 2015Publication date: October 1, 2015Applicant: TROVAGENE, INC.Inventors: Samuil R Umansky, Hovsep S Melkonyan, Erik Meyer, William John Feaver
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Publication number: 20140363807Abstract: The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identifies individuals at risk of developing or in the early stages of cervical carcinoma.Type: ApplicationFiled: February 4, 2014Publication date: December 11, 2014Applicant: TROVAGENE, INC.Inventor: Natalya Ossina
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Patent number: 8642261Abstract: The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identify individuals at risk of developing or in the early stages of cervical carcinoma.Type: GrantFiled: October 26, 2009Date of Patent: February 4, 2014Assignee: Trovagene, Inc.Inventors: Samuil R. Umansky, Zhenghan Xin, Natalya Ossina
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Patent number: 8486626Abstract: Described are non-invasive methods of detecting in vivo cell death by measuring levels of ubiquitous and tissue specific miRNA. The method can be applied for detection of pathologies caused or accompanied by cell death, as well as for diagnosis of infectious disease, cytotoxic effects induced by different chemical or physical factors, and the presence of specific fetal abnormalities.Type: GrantFiled: August 22, 2008Date of Patent: July 16, 2013Assignee: Trovagene, Inc.Inventors: Samuil R. Umansky, Hovsep S. Melkonyan, Vladimir S. Scheinker
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Publication number: 20130178544Abstract: The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The analysis of the nucleic acids is performed through hybridization of the nucleic acids with specific probes, or through a chain amplification reaction with specific primers. The methods are applicable to all viral pathogenic agents, including RNA, DNA, episomal, or integrated viruses.Type: ApplicationFiled: February 26, 2013Publication date: July 11, 2013Applicant: Trovagene, Inc.Inventors: Hovsep S. MELKONYAN, Angela Cannas, Louis David Tomei, Samuil R. Umansky
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Patent number: 8383335Abstract: The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The analysis of the nucleic acids is performed through hybridization of the nucleic acids with specific probes, or through a chain amplification reaction with specific primers. The methods are applicable to all viral pathogenic agents, including RNA, DNA, episomal, or integrated viruses.Type: GrantFiled: May 24, 2011Date of Patent: February 26, 2013Assignee: Trovagene, Inc.Inventors: Hovsep Melkonyan, Angela Cannas, Louis David Tomei, Samuil R. Umansky