Patents Assigned to Trustees of Darmouth College
  • Patent number: 9673729
    Abstract: High power output may be obtained from a photovoltaic (PV) system by controlling each photovoltaic cell of a solar array individually to operate at its maximum power point. Each cell may have associated power electronics and control circuitry that may be integrated together on a chip which may be advantageously implemented in CMOS, enabling reductions in cost and size. A perturb and observe algorithm may be used to find the maximum power point by measuring the power produced at different operating points, and modifying the operating point in the direction of increased power production. In one aspect, performance of a perturb and observe algorithm may be improved in the presence of noise.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: June 6, 2017
    Assignees: Massachusetts Institute of Technology, Trustees of Darmouth College
    Inventors: David Perreault, Robert Pilawa-Podgurski, Charles Sullivan, Alexander Latham
  • Patent number: 9163063
    Abstract: Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: October 20, 2015
    Assignees: Trustees of Darmouth College, Mayo Foundation for Medical Education and Research
    Inventors: Debabrata Mukhopadhyay, Priyabrata Mukherjee, Mark Spaller
  • Patent number: 8592168
    Abstract: The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: November 26, 2013
    Assignee: Trustees of Darmouth College
    Inventor: William G. North
  • Publication number: 20030236303
    Abstract: Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
    Type: Application
    Filed: March 24, 2003
    Publication date: December 25, 2003
    Applicant: Trustees of Darmouth College
    Inventors: Gordon W. Gribble, Tadashi Honda, Michael B. Sporn, Nanjoo Suh
  • Patent number: 6472385
    Abstract: Compositions which abrogate DNA damage induced cell cycle arrest thereby enhancing the cell killing activity of DNA damaging anticancer agents for use in the treatment of cancer, and in particular, p53 defective cancers are provided.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: October 29, 2002
    Assignee: Trustees of Darmouth College
    Inventors: Alan Eastman, Gordon W. Gribble
  • Publication number: 20020009450
    Abstract: Method for the treatment of multiple sclerosis and other T cell mediated autoimmune disorders is described. The method involves administering to a subject a therapeutically effective amount of an antagonist of a receptor on a surface of a T cell which mediates contact dependent helper effector functions, for example, an anti-gp39 antibody.
    Type: Application
    Filed: May 8, 2001
    Publication date: January 24, 2002
    Applicant: Trustees of Darmouth College
    Inventors: Randolph J. Noelle, Eric Claassen
  • Patent number: 5496699
    Abstract: Methods are provided for detecting and quantitating gene sequences, such as mutated genes and oncogenes, in biological fluids. The fluid sample (e.g., plasma, serum, urine, etc.) is obtained, deproteinized and the DNA present in the sample is extracted. Following denaturation of the DNA, an amplification procedure, such as PCR or LCR, is conducted to amplify the mutated gene sequence.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: March 5, 1996
    Assignee: Trustees of Darmouth College
    Inventor: George D. Sorenson