Abstract: Method are provided for evaluating reaction time data obtained from a stimulus-response testing system. One exemplary method comprises: obtaining reaction time data, the reaction time data comprising a plurality of reaction times, each reaction time comprising an estimate of a time required for a subject to respond to a corresponding stimulus event; assigning a weight to each reaction time in the reaction time data in accordance with a weighting function, the weighting function comprising a rule that defines a mapping between reaction times and corresponding weights; and determining a weighted reaction time metric based at least in part on a sum of the weights assigned to the reaction times in the reaction time data.

Abstract: Systems and methods are provided for generating individualized predictions of alertness or performance for human subjects. Alertness or performance predictions may be individualized to incorporate a subject's individual traits and/or individual states. These individual traits and/or individual states (or parameters which represent these individual traits and/or individual states) may be represented by random variables in a mathematical model of human alertness. The mathematical model and/or prediction techniques may incorporate effects of the subject's sleep timing, the subject's intake of biologically active agents (e.g. caffeine) and/or the subject's circadian rhythms. The mathematical model and/or prediction techniques may incorporate feedback from the subject's measured alertness and/or performance.

Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast cancer predisposing gene (BRCA2), some mutant alleles of which cause susceptibility to cancer, in particular breast cancer. More specifically, the invention relates to germline mutations in the BRCA2 gene and their use in the diagnosis of predisposition to breast cancer. The present invention further relates to somatic mutations in the BRCA2 gene in human breast cancer and their use in the diagnosis and prognosis of human breast cancer. Additionally, the invention relates to somatic mutations in the BRCA2 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA2 gene, including gene therapy, protein replacement therapy and protein mimetics.

Abstract: Antibodies specifically reactive with an abnormally phosphorylated peptide comprising SEQ ID NO: 3 wherein a serine in SEQ ID NO: 3 is abnormally phosphorylated are provided. Methods of detecting abnormally phosphorylated .tau. in a test sample and methods of diagnosing Alzheimer's Disease with these antibodies are also provided.

Abstract: Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

Abstract: Methods for the suppression and inhibition of carcinogenesis are provided in which a Bowman-Birk product produced in accordance with the processes described are administered. The methods are particularly adaptable to the prevention or treatment of colon, lung, liver, esophagus, oral epithelium (squamous carcinomas), and bone marrow cancer. The preferred mode of administration is as a dietary supplement.

Abstract: A multiple tuning NMR probe includes a radio frequency (RF) probe tuned by means of a circuit which creates a multiple pole circuit response in the probe, each of the poles being sufficiently separated from each other as to cause resonance of the probe at distinct frequencies. When tuning for nuclei with resonances substantially apart, this function may be accomplished using a parallel capacitor-inductor (L-C) trap with an impedance matching network. When tuning for nuclei with substantially closely spaced resonances, a tank circuit is used which has a single resonance which is split into two resonances by strongly coupling it to another tank circuit in resonance with the sample coil tank circuit.