Patents Assigned to Tufts Medical Center, Inc.
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Patent number: 9199067Abstract: An endovascular implantable shunt device for draining cerebrospinal fluid from a patient's subarachnoid space includes a shunt having opposed first and second ends, a one-way valve is located at the first end of the shunt, a helical tip is disposed at the second end, and a hollow passageway extends between the helical tip and one-way valve. The helical tip is constructed to penetrate a patient's sinus wall. Cerebrospinal fluid drains through the helical tip and out through the valve.Type: GrantFiled: February 13, 2014Date of Patent: December 1, 2015Assignee: Tufts Medical Center, Inc.Inventors: Carl Heilman, Adel M. Malek
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Patent number: 9095420Abstract: An intravascular stent is provided for treatment of an aneurysm in a vessel wall of a cranial blood vessel. The stent includes at least one a flow-shaping member including a flow-facing surface that protrudes from an inner surface of the stent and is configured to control at least one of the direction, velocity and secondary flow characteristics of the blood flow within the aneurysm.Type: GrantFiled: January 18, 2012Date of Patent: August 4, 2015Assignee: TUFTS MEDICAL CENTER, INC.Inventor: Adel M. Malek
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Publication number: 20140366887Abstract: An oral airway includes a curved body having a front wall which includes a concave portion of the body, and a rear wall which includes a convex portion of the body. The front wall is configured to translate relative to the rear wall, while remaining engaged with the rear wall. In addition, the rear wall is formed of a first material, and at least a portion of the front wall is formed of a second material, the second material being relatively flexible as compared to the first material.Type: ApplicationFiled: August 30, 2012Publication date: December 18, 2014Applicant: Tufts Medical Center, Inc.Inventor: Pei-Shan Zhao
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Publication number: 20140336559Abstract: An implantable shunt device for draining cerebrospinal fluid from a patient's subarachnoid space. The device includes a shunt having opposed first and second ends. A one-way valve is located at the first end of the shunt. A helical tip is disposed at the second end. The helical tip is constructed to penetrate a sinus wall of the patient. Upon implantation, a hollow passageway extends between the helical tip and one-way valve such that fluid can be drained through the helical tip and out through the valve. The endovascular cerebrospinal fluid shunt of the present invention can be placed into a patient percutaneously via a catheter inserted into the venous system of the body through a needle hole, without the need for open surgery and the skin incisions required with current shunt devices. The device also allows for more physiologic drainage of cerebrospinal fluid since the device is shunting cerebrospinal fluid into the same cerebral venous system that occurs naturally in normal people.Type: ApplicationFiled: February 13, 2014Publication date: November 13, 2014Applicant: TUFTS MEDICAL CENTER, INC.Inventors: Carl Heilman, Adel M. Malek
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Publication number: 20140309125Abstract: Described herein are compositions, kits and methods for diagnosing and tracking the progression of AMD in a subject by detecting the presence or absence of particular lipid metabolism markers associated with AMD. Predictive computer models of disease risk are also disclosed.Type: ApplicationFiled: December 10, 2013Publication date: October 16, 2014Applicants: THE GENERAL HOSPITAL CORPORATION, TUFTS MEDICAL CENTER, INC.Inventors: Johanna M. Seddon, Mark Daly
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Patent number: 8841109Abstract: Polypeptide agents useful in the treatment of IgA1 deposition diseases and methods of using such polypeptide agents. Methods of screening for inhibitors of IgA1 proteases and agents that inhibit IgA1 proteases are also disclosed.Type: GrantFiled: April 20, 2010Date of Patent: September 23, 2014Assignees: The University of Kansas, Tufts Medical Center, Inc.Inventors: Todd Holyoak, Jiazhou Qiu, Andrew G. Plaut
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Publication number: 20140243378Abstract: Disclosed are methods of treating a muscle disease and improving normal muscle function by administering a therapeutically effective amount of an isoprenoid antibiotic. Also disclosed are methods of upregulating hnRNP L and hnRNP L targets by administering a therapeutically effective amount of an isoprenoid antibiotic. Methods of screening compounds for use in treating muscle disease and improving muscle function are also described.Type: ApplicationFiled: October 19, 2012Publication date: August 28, 2014Applicants: Tufts Medical Center, Inc., Children's Medical Center CorporationInventors: Isabelle Draper, Louis M. Kunkel, Matthew S. Alexander, Alan S. Kopin
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Publication number: 20140234319Abstract: Endoglin has now been shown to be an important target of therapy to reduce disease symptoms associated with heart failure, particularly cardiac fibrosis. Soluble Endoglin is identified as an anatogonist to TGF?1 activity, while membrane-bound Endoglin is identified as a necessary component to promote TGF?1 activity in heart failure. The present invention therefore features methods and kits for treatment of subject having heart failure or a related disorder by administering a composition that decreases TGF?1 signaling through either direct inhibition of membrane-bound Endoglin or promoting expression of soluble Endoglin.Type: ApplicationFiled: July 31, 2012Publication date: August 21, 2014Applicant: Tufts Medical Center, Inc.Inventors: Navin K. Kapur, Richard H. Karas
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Patent number: 8808328Abstract: A spinal implant includes a first rod, a second rod, and connector. The first rod has a first end configured to be connected to a first bone, a second end opposed to the first end, and a longitudinal axis that passes through the first and second ends. The second rod has a first end configured to be connected to the second bone, a second end opposed to the first end. The second rod is parallel to the longitudinal axis and non-coaxial with the first rod, and at least a portion of the second end of the second rod overlaps the second end of the first rod. The connector connects the second end of the first rod to the second end of the second rod, and is configured to urge the first rod and the second rod in opposed directions that are parallel to the longitudinal axis.Type: GrantFiled: April 2, 2013Date of Patent: August 19, 2014Assignee: Tufts Medical Center, Inc.Inventor: Steven W. Hwang
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Publication number: 20140227718Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.Type: ApplicationFiled: January 30, 2013Publication date: August 14, 2014Applicant: Tufts Medical Center, Inc.Inventors: Athan Kuliopulos, Lidija Covic
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Patent number: 8781194Abstract: An approach to automatically detecting, classifying and/or highlighting abnormal structures such as brain aneurysms is based on three-dimensional studies of the brain vessels. The approach is applicable to effectively all currently available modalities of acquisition of the cerebral vessels, including magnetic resonance angiography (MRA), computed tomography angiography (CTA), and conventional catheter-based three-dimensional rotational angiography (3DRA).Type: GrantFiled: April 16, 2010Date of Patent: July 15, 2014Assignee: Tufts Medical Center, Inc.Inventors: Adel M. Malek, Eric Miller, Alexandra Lauric
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Publication number: 20140107671Abstract: Needle-stick injuries are associated with considerable risk of morbidity for healthcare workers and patients. The present invention of a handheld surgical suturing device allows tor visualization of surgical field and better control of the suture needle with possible one-hand operation. The device also provides active safety features that protect the surgeon from needle-stick injury.Type: ApplicationFiled: October 8, 2013Publication date: April 17, 2014Applicant: TUFTS MEDICAL CENTER, INC.Inventor: William Travis LAU
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Publication number: 20140087993Abstract: Disclosed here is the rational design and use of potent and specific GPCR antagonist pepducins based on GPCR regions such as the third intracellular loop and adjacent regions.Type: ApplicationFiled: April 9, 2012Publication date: March 27, 2014Applicant: TUFTS MEDICAL CENTER, Inc.Inventors: Athan Kuliopulos, Lidija Covic
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Patent number: 8672871Abstract: An implantable shunt device for draining cerebrospinal fluid from a patient's subarachnoid space includes a shunt having opposed first and second ends and a one-way valve located at the first end of the shunt. A hollow passageway extends between the tip and one-way valve such that fluid can be drained through the tip and out through the valve. The endovascular cerebrospinal fluid shunt of the present invention can be placed into a patient percutaneously via a catheter inserted into the venous system of the body through a needle hole, without the need for open surgery. The device allows for more physiologic drainage of cerebrospinal fluid since the device shunts cerebrospinal fluid into the same cerebral venous system that occurs naturally in normal people.Type: GrantFiled: August 8, 2012Date of Patent: March 18, 2014Assignee: Tufts Medical Center, Inc.Inventors: Carl Heilman, Adel M. Malek
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Publication number: 20140031920Abstract: An intravascular stent is provided for treatment of an aneurysm in a vessel wall of a cranial blood vessel. The stent includes at least one a flow-shaping member including a flow-facing surface that protrudes from an inner surface of the stent and is configured to control at least one of the direction, velocity and secondary flow characteristics of the blood flow within the aneurysm.Type: ApplicationFiled: January 18, 2012Publication date: January 30, 2014Applicant: Tufts Medical Center, Inc.Inventor: Adel M. Malek
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Patent number: 8577111Abstract: High resolution time sequences of 3D images that show the dynamics of a time varying changes are provided. The 3D time series of images representing an object that include time varying changes may be produced from lower dimensional image time sequences, such as 2D images. The 2D images may be generated using angiography and may include fluid flow information (e.g., arrival times). The fluid flow information may be provided, for example, by injecting a chemical into the fluid and analyzing its position in the object or body over time. A varying contrast model may be applied to determine the location of the chemical at different points in time which may assist in detecting an ailment.Type: GrantFiled: March 7, 2013Date of Patent: November 5, 2013Assignees: The Charles Stark Draper Laboratory, Inc., Tufts Medical Center, Inc.Inventors: Rami Mangoubi, Mukund Desai, Adel Malek, Andrew Copeland
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Publication number: 20130281761Abstract: A cardiac assist device includes a cannula that terminates in a flexible tip. The tip is generally Y-shaped and includes a proximal end that extends from the end of the cannula, and a bifurcated distal end opposed to the proximal end. The bifurcated distal end includes a first portion detached from a second portion, and the tip further includes a pair of through channels extending from the proximal end to the bifurcated distal end. The tip is configured so that one channel of the pair of channels extends through the first portion, and the other channel of the pair of channels extends through the second portion.Type: ApplicationFiled: October 31, 2011Publication date: October 24, 2013Applicant: Tufts Medical Center, Inc.Inventor: Navin K. Kapur
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Patent number: 8563519Abstract: The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.Type: GrantFiled: March 7, 2005Date of Patent: October 22, 2013Assignee: Tufts Medical Center, Inc.Inventors: Athan Kuliopulos, Lidija Covic
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Publication number: 20130268003Abstract: A spinal implant includes a first rod, a second rod, and connector. The first rod has a first end configured to be connected to a first bone, a second end opposed to the first end, and a longitudinal axis that passes through the first and second ends. The second rod has a first end configured to be connected to the second bone, a second end opposed to the first end. The second rod is parallel to the longitudinal axis and non-coaxial with the first rod, and at least a portion of the second end of the second rod overlaps the second end of the first rod. The connector connects the second end of the first rod to the second end of the second rod, and is configured to urge the first rod and the second rod in opposed directions that are parallel to the longitudinal axis.Type: ApplicationFiled: April 2, 2013Publication date: October 10, 2013Applicant: Tufts Medical Center, Inc.Inventor: Steven W. Hwang
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Patent number: 8551122Abstract: Needle-stick injuries are associated with considerable risk of morbidity for healthcare workers and patients. The present invention of a handheld surgical suturing device allows for visualization of surgical field and better control of the suture needle with possible one-hand operation The device also provides active safety features that protect the surgeon from needle-stick injury.Type: GrantFiled: July 24, 2009Date of Patent: October 8, 2013Assignee: Tufts Medical Center, Inc.Inventor: William Travis Lau