Abstract: An inflatable cushioned seating assembly and method is disclosed, which assembly and method alternates the areas of supporting contact of inflatable portions of the assembly with the body of a user seated in the seating device while providing continuous overall cushioned support to the user to thereby reduce or alleviate medical problems and/or fatigue caused by prolonged seating. The assembly includes a plurality of first and second alternating sets of elongated inflatable compartments that extend across both the seat and backrest of a seating device, with each set substantially independently supporting the user when pressurized to a pressure greater than that of the other set. Selected compartments of each set may be varied in size and/or material for support of selected contours of the user's body, for example, the lumbar region of the spine, and the compartments extend beyond the front edge of the seat portion of the seating device.