Patents Assigned to Two To Biotech Ltd.
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Patent number: 9296786Abstract: The present invention relates to an isolated polypeptide comprising (a) the amino acid sequence set forth in SEQ ID NO: 21; or (b) an amino acid sequence that is at least 95% identical to SEQ ID NO: 21, and to therapeutic treatments based thereon.Type: GrantFiled: January 2, 2014Date of Patent: March 29, 2016Assignee: Two To Biotech Ltd.Inventors: Tamara Sandler, Orly Devary
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Patent number: 9150642Abstract: Polyclonal and monoclonal antibodies which specifically recognize the KTPAF50 protein, and compositions comprising thereof are provided. Also provided are uses of the KTPAF50-specific antibodies, in the diagnosis and therapeutic of conditions such as cancer, autoimmune diseases, graft rejection, neurodegenerative diseases and diabetes.Type: GrantFiled: June 29, 2010Date of Patent: October 6, 2015Assignee: Two To Biotech Ltd.Inventors: Orly Devary, Tamara Sandler
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Publication number: 20140155324Abstract: The invention relates to polypeptides exhibiting metabolic-modulating as well as immunomodulatory properties, nucleic acids encoding them, compositions comprising them, and methods of treating metabolic disorders and/or immune-related disorders comprising their administration and to their use in preparing pharmaceutical compositions for the treatment, amelioration, prophylaxis or delaying the onset of at least one of a metabolic disorder and an immune-related disorder.Type: ApplicationFiled: August 6, 2012Publication date: June 5, 2014Applicant: TWO TO BIOTECH LTD.Inventors: Tamara Sandler, Orly Devary
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Patent number: 8647632Abstract: Provided herein are four polypeptides, named PRT5, PRT6, PRT7 and PRT8, the nucleic acids encoding the same, compositions comprising the proteins, as well as their uses in therapeutic and diagnostic methods. Antibodies which specifically recognize the polypeptides are also provided, as well as their uses. Characterization of each protein showed that PRT5 and PRT8 are involved in glucose metabolism, PRT6 is involved in androgen regulation, while PRT7 correlates with cancer.Type: GrantFiled: August 2, 2010Date of Patent: February 11, 2014Assignee: Two to Biotech Ltd.Inventors: Tamara Sandler, Orly Devary
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Patent number: 8329861Abstract: Provided is a novel, isolated polypeptide including an amino acid sequence of SEQ. ID. NO: 2 or SEQ. ID. NO: 4, and the nucleic acid molecule which encodes it. The polypeptide may be used in a method for treating various diseases including cancer, immune associated, viral and inflammatory diseases.Type: GrantFiled: December 25, 2008Date of Patent: December 11, 2012Assignee: Two To Biotech Ltd.Inventors: Tamar Sandler, Orly Devary
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Publication number: 20120121602Abstract: Provided herein are four polypeptides, named PRT5, PRT6, PRT7 and PRT8, the nucleic acids encoding the same, compositions comprising the proteins, as well as their uses in therapeutic and diagnostic methods. Antibodies which specifically recognize the polypeptides are also provided, as well as their uses. Characterization of each protein showed that PRT5 and PRT8 are involved in glucose metabolism, PRT6 is involved in androgen regulation, while PRT7 correlates with cancer.Type: ApplicationFiled: August 2, 2010Publication date: May 17, 2012Applicant: TWO TO BIOTECH LTD.Inventors: Tamara Sandler, Orly Devary
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Publication number: 20120100147Abstract: Polyclonal and monoclonal antibodies which specifically recognize the KTPAF50 protein, and compositions comprising thereof are provided. Also provided are uses of the KTPAF50-specific antibodies, in the diagnosis and therapeutic of conditions such as cancer, autoimmune diseases, graft rejection, neurodegenerative diseases and diabetes.Type: ApplicationFiled: June 29, 2010Publication date: April 26, 2012Applicant: TWO TO BIOTECH LTD.Inventors: Orly Devary, Tamara Sandler
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Publication number: 20100286026Abstract: Provided is a novel, isolated polypeptide including an amino acid sequence of SEQ. ID. NO: 2 or SEQ. ID. NO: 4, and the nucleic acid molecule which encodes it. The polypeptide may be used in a method for treating various diseases including cancer, immune associated, viral and inflammatory diseases.Type: ApplicationFiled: December 25, 2008Publication date: November 11, 2010Applicant: TWO TO BIOTECH LTD.Inventors: Tamar Sandler, Orly Devary