Patents Assigned to U.S. Department of Veterans Affairs
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Patent number: 11814687Abstract: The present invention features methods for characterizing mutational profiles in patients with bladder cancer.Type: GrantFiled: August 7, 2020Date of Patent: November 14, 2023Assignees: The Broad Institute, Inc., The General Hospital Corporation, Baylor College of Medicine, The Brigham and Women's Hospital, Inc., Northwestern University, The Johns Hopkins University, United States Government as represented by the U.S. Department of Veterans AffairsInventors: Jaegil Kim, Gad Getz, Seth Paul Lerner, David Kwiatkowski, Joshua Meeks, Joaquim Bellmunt, David McConkey
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Patent number: 11311447Abstract: An agility trainer apparatus that provides a robotic system that applies forces laterally to a harness worn by a person during walking so as to provide highly controllable interventions targeting locomotor stability.Type: GrantFiled: June 29, 2018Date of Patent: April 26, 2022Assignees: Northwestern University, U.S. Department of Veterans AffairsInventors: Keith E. Gordon, Geoffrey L. Brown, Mengnan Wu, Felix C. Huang
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Patent number: 11129734Abstract: An ankle-foot prosthesis includes a foot plate, an ankle frame attached to the foot plate, a yoke pivotally connected to the ankle frame and including a member for attaching to a leg, a damper having a first end connected to the yoke and a second end connected to the ankle frame, and a control mechanism for switching the damper between low and high settings.Type: GrantFiled: May 7, 2019Date of Patent: September 28, 2021Assignees: U.S. Department of Veterans Affairs, Regents of the University of MinnesotaInventors: Andrew H. Hansen, Eric A. Nickel
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Publication number: 20200370133Abstract: The present invention features methods for characterizing mutational profiles in patients with bladder cancer.Type: ApplicationFiled: August 7, 2020Publication date: November 26, 2020Applicants: The Broad Institute, Inc., The General Hospital Corporation, Baylor College of Medicine, The Brigham and Women?s Hospital, Inc., Northwestern University, The Johns Hopkins University, United States Government as represented by the U.S. Department of Veterans AffairsInventors: Jaegil Kim, Gad Getz, Seth Paul Lerner, David Kwiatkowski, Joshua Meeks, Joaquim Bellmunt, David McConkey
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Publication number: 20200222266Abstract: An agility trainer apparatus that provides a robotic system that applies forces laterally to a harness worn by a person during walking so as to provide highly controllable interventions targeting locomotor stability.Type: ApplicationFiled: June 29, 2018Publication date: July 16, 2020Applicants: Northwestern University, U.S. Department of Veterans AffairsInventors: Keith E. Gordon, Geoffrey L. Brown, Mengnan Wu, Felix C. Huang
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Publication number: 20200163993Abstract: Disclosed are therapeutic compositions, methods of preparing, and methods use for the treatment of infectious diseases and cancer. More specifically, Natural Killer Cell (NK Cell)-derived exosomes are demonstrated as potent therapeutic agents that can kill tumor cells in vivo, but do not kill normal cells. The exosomes can also be used to treat infectious disease.Type: ApplicationFiled: May 8, 2018Publication date: May 28, 2020Applicants: Saint Louis University, U.S. Department of Veterans AffairsInventor: Jacki KORNBLUTH
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Patent number: 10660553Abstract: Method and apparatus for providing reliable blood oxygen (SaO2) and heart rate measurements includes a chemical energy heating source in conjunction with a harness that is adapted to secure the chemical energy heating source and a pulse oximeter probe proximate to a region of the body which is to be warmed prior to measurement. Preferably, the chemical energy heating source is in the form a mixture including a metal powder, which releases heat at a predetermined rate via oxidation of the metal powder when exposed to the atmosphere. The apparatus may be designed to be reusable or disposable and can be used in a transmission or reflectance mode, or both.Type: GrantFiled: September 7, 2017Date of Patent: May 26, 2020Assignee: U.S. Department of Veteran AffairsInventor: Catherine P. Abee
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Publication number: 20200147086Abstract: In one aspect, the present disclosure provides methods of treating a bacterial infection using an inhibitor of the nucleotidyltransferase superfamily enzyme. In some embodiments, the compounds have one of the following formulas (I), (II), (III), or (IV) wherein R1, R2, and R3 are as defined herein or a pharmaceutically acceptable salt thereof. The compounds may be used to treat a bacterial infection including an infection of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species.Type: ApplicationFiled: May 16, 2018Publication date: May 14, 2020Applicants: Saint Louis University, U.S. Department of Veterans Affairs, Research Foundation of the City University of New YorkInventors: Feng CAO, John E. TAVIS, Maureen J. DONLIN, Marvin J. MEYERS, Ryan P. MURELLI, Cari ORTH, Bahaa ELGENDY
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Patent number: 10618944Abstract: The present disclosure relates to the SALL1 tumor suppressor. Methods of employing SALL1 to treat cancer, as well as the underlying mechanism by which this occurs, also are described.Type: GrantFiled: February 26, 2016Date of Patent: April 14, 2020Assignees: Saint Louis University, U.S. Department of Veterans AffairsInventors: Guangyong Peng, Michael Rauchman, Chunling Ma, Fang Wang
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Patent number: 10410355Abstract: Disclosed are methods and systems for analyzing data. An example method can comprise receiving volume data representative of an object. A first graph can be generated based on the volume data. The first graph can comprise nodes arranged in a Euclidean space. A deformation field can be determined based on the volume data. The deformation field can be applied to the first graph to form a second graph. The second graph can comprise nodes arranged in a non-Euclidean space. The second graph can be segmented.Type: GrantFiled: March 23, 2015Date of Patent: September 10, 2019Assignees: U.S. Department of Veterans Affairs, UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: Michael D. Abramoff, Li Tang, Xiaodong Wu
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Patent number: 10369254Abstract: The invention provides for a device, system, and methods for using the same with kidney progenitor cells, specifically ureteric bud (UB) cells, metanephric mesenchymal (MM) cells, and the stromal cell (SC) subpopulation of the metanephric mesenchyme, to generate an embryonic kidney organoid that can be implanted into a mammalian subject to create a living, functional kidney.Type: GrantFiled: February 6, 2015Date of Patent: August 6, 2019Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, U.S. DEPARTMENT OF VETERANS AFFAIRSInventors: Norimoto Yanagawa, Masaki Nishikawa, Morgan Hamon, Peter Viktor Hauser
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Patent number: 10105243Abstract: An ankle-foot prosthesis includes a foot plate, an ankle frame attached to the foot plate, a yoke pivotally connected to the ankle frame and including a member for attaching to a leg, a damper having a first end connected to the yoke and a second end connected to the ankle frame, and a control mechanism for switching the damper between low and high settings.Type: GrantFiled: November 22, 2016Date of Patent: October 23, 2018Assignees: U.S. Department of Veterans Affairs, Regents of the University of MinnesotaInventors: Andrew H. Hansen, Eric A. Nickel
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Patent number: 10018298Abstract: An exercise machine has a mobile base and an upright support extending upwards from the mobile base. An upper support assembly extends forward from an upper portion of the upright support and an exercise device is suspended from the upper support assembly at a location spaced forward from the upright support. The mobile base has caster wheels and can be positioned from either side of a bed so as to extend partially under a bed with the upright support located on one side of the bed and the exercise device suspended over the bed in a position accessible by a patient lying supine in the bed for performing exercise. An anchoring system resists movement of the base for stability when exercise is performed.Type: GrantFiled: March 6, 2015Date of Patent: July 10, 2018Assignee: U.S. Department of Veterans AffairsInventors: Gary Goldish, Andrew Hansen, Eric Nickel, John Ferguson
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Publication number: 20180108139Abstract: Disclosed are systems and methods for image segmentation using convolutional networks. Image data comprising an image hypervolume can be received. The image hypervolume can be provided to a trained convolutional neural network (CNN). The CNN can output a segmentation of the image hypervolume.Type: ApplicationFiled: October 19, 2017Publication date: April 19, 2018Applicant: U.S. Department of Veterans AffairsInventors: Michael Abramoff, Xiaodong Wu
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Patent number: 9889105Abstract: An in vivo method of inhibiting tumor growth, specifically pancreatic cancer, includes administering to a subject in need thereof an effective amount of a compound, composition, and/or a pharmaceutical formulation including crocetinic acid.Type: GrantFiled: April 7, 2014Date of Patent: February 13, 2018Assignees: U.S. Department of Veterans Affairs, Univ. of Kansas, The Curators of the Univ. of MissouriInventors: Animesh Dhar, William G. Gutheil
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Patent number: 9883812Abstract: Techniques and systems are disclosed for implementing multi-core beamforming algorithms. In one aspect, a method of implementing a beamformer technique includes using a spatial filter that contains lead-fields of two simultaneous dipole sources rather than a linear combination of the two to directly compute and obtain optimal source orientations and weights between two highly-correlated sources.Type: GrantFiled: June 28, 2011Date of Patent: February 6, 2018Assignees: The Regents of the University of California, U.S. Department of Veterans AffairsInventors: Ming-Xiong Huang, Roland R. Lee, Mithun Diwakar, Omer Tal, Thomas T. Liu
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Patent number: 9868786Abstract: Provided are methods for suppressing IgE and IgG-mediated allergic reactions through monoclonal antibody applications. More specifically, methods are herein provided for safe induction of rapid desensitization. Specific embodiments are herein provided for suppressing allergic reactions in a subject, including specific methods of providing a monoclonal antibody selected from the group consisting of anti-Fc?RIa and anti-Fc?RIIb / RIII; administering the antibody to a subject at a dose that is lower than the level required to induce shock; and administering sequentially escalating doses of the monoclonal antibody so as to induce rapid desensitization to an allergen, thereby suppressing allergic reaction in the subject.Type: GrantFiled: April 12, 2012Date of Patent: January 16, 2018Assignees: University of Cincinnati, Children's Hospital Medical Center, U.S. Department of Veterans Affairs, Medizinische Universität WienInventors: Fred D. Finkelman, Marat V. Khodoun, Durga Krishnamurthy, Richard T. Strait, Zeynep (Yesim) Kucuk
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Publication number: 20170367629Abstract: Method and apparatus for providing reliable blood oxygen (SaO2) and heart rate measurements includes a chemical energy heating source in conjunction with a harness that is adapted to secure the chemical energy heating source and a pulse oximeter probe proximate to a region of the body which is to be warmed prior to measurement. Preferably, the chemical energy heating source is in the form a mixture including a metal powder, which releases heat at a predetermined rate via oxidation of the metal powder when exposed to the atmosphere. The apparatus may be designed to be reusable or disposable and can be used in a transmission or reflectance mode, or both.Type: ApplicationFiled: September 7, 2017Publication date: December 28, 2017Applicant: U.S. Department of Veterans AffairsInventor: Catherine P. ABEE
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Patent number: 9795332Abstract: Method and apparatus for providing reliable blood oxygen (SaO2) and heart rate measurements includes a chemical energy heating source in conjunction with a harness that is adapted to secure the chemical energy heating source and a pulse oximeter probe proximate to a region of the body which is to be warmed prior to measurement. Preferably, the chemical energy heating source is in the form a mixture including a metal powder, which releases heat at a predetermined rate via oxidation of the metal powder when exposed to the atmosphere. The apparatus may be designed to be reusable or disposable and can be used in a transmission or reflectance mode, or both.Type: GrantFiled: November 26, 2012Date of Patent: October 24, 2017Assignee: U.S. Department of Veterans AffairsInventor: Catherine P. Abee
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Publication number: 20170156894Abstract: An ankle-foot prosthesis includes a foot plate, an ankle frame attached to the foot plate, a yoke pivotally connected to the ankle frame and including a member for attaching to a leg, a damper having a first end connected to the yoke and a second end connected to the ankle frame, and a control mechanism for switching the damper between low and high settings.Type: ApplicationFiled: February 16, 2017Publication date: June 8, 2017Applicants: U.S. Department of Veterans Affairs, Regents of the University of MinnesotaInventors: Andrew H. HANSEN, Eric A. NICKEL