Abstract: The present invention relates to therapeutic use of calreticulin in treatment of angiogenic eye diseases. Different treatment methods and pharmaceutical compositions comprising calreticulin are disclosed.
Abstract: A method using yeast as a host for production of human ER chaperone proteins, using endogenous signal peptides of intracellular human proteins that are recognized and correctly processed in the yeast cells to subsequently lead to the secretion of the human proteins. The resultant proteins possessed native amino acid sequence and were biologically active. Moreover, secretion allowed simple one-step purification of native recombinant human proteins with high yields.
Type:
Grant
Filed:
January 12, 2015
Date of Patent:
October 24, 2017
Assignee:
UAB BALTYMAS
Inventors:
Evaldas Ciplys, Rimantas Slibinskas, Kestutis Sasnauskas, Marek Michalak, Leslie Ina Gold
Abstract: A method using yeast as a host for production of human ER chaperone proteins, using endogenous signal peptides of intracellular human proteins that are recognized and correctly processed in the yeast cells to subsequently lead to the secretion of the human proteins. The resultant proteins possessed native amino acid sequence and were biologically active. Moreover, secretion allowed simple one-step purification of native recombinant human proteins with high yields.
Type:
Application
Filed:
January 12, 2015
Publication date:
July 9, 2015
Applicant:
UAB BALTYMAS
Inventors:
Evaldas Ciplys, Rimantas Slibinskas, Kestutis Sasnauskas, Marek Michalak, Leslie Ina Gold