Patents Assigned to Unicler
  • Patent number: 4277497
    Abstract: Method of providing an analgesic effect by administring compounds having the general formula I ##STR1## in which each of R.sub.1 and R.sub.4 is independently hydrogen or a C.sub.1-4 alkyl, andeach of R.sub.2 and R.sub.3 is independently hydrogen, fluorine, chlorine, bromine or a C.sub.1-4 alkylor their pharmaceutically acceptable salts.The invention provides also compounds of fromula (I) where each of R.sub.1, R.sub.2 and R.sub.3 is independently hydrogen or C.sub.1-4 alkyl.
    Type: Grant
    Filed: March 16, 1979
    Date of Patent: July 7, 1981
    Assignee: Unicler
    Inventor: Jean-Pierre M. J. Fromantin
  • Patent number: 4209517
    Abstract: The invention provides new compounds of the formula ##STR1## in which one of the symbols R.sub.1 and R.sub.2 denoted a hydrogen atom and the other a hydroxyl group or, together, the two denote an oxygen atom, and R.sub.3 denotes an alkenyl group having 3 to 6 carbon atoms, a cyclohexyl group, or an aminoalkyl group in which the alkyl group has from 1 to 3 carbon atoms and the amino group is a morpholino, 4-methylpiperazino or piperidino radical, as well as the pharmaceutically acceptable addition salts of the compounds containing an amino group, which are useful as tranquilizers, anticonvulsants and anti-depressants.
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: June 24, 1980
    Assignee: Unicler
    Inventors: Andre M. Riveron, Jacques N. Astoin, Alain D. Marivain, Micheline Crucifix born Depheimer, Martine M. Lapotre, Yvette M. Torrens born Le Gargean
  • Patent number: 4177271
    Abstract: Hydroxy- and oxo-substituted .alpha.-benzylidenylcycloalkanes having the formula: ##STR1## Z.sub.1, Z.sub.2 and Z.sub.3 each denotes a methoxy group or Z.sub.1 or Z.sub.2 and Z.sub.3 together denote a methylenedioxy group, and Z.sub.3 is a hydrogen atom or chlorine atom, one of the symbols R.sub.1 and R.sub.2 denotes a hydrogen atom and the other denotes a hydroxyl group or, together the two denote an oxygen atom; R.sub.3 denotes a hydrogen atom or a methyl group; R.sub.4 denotes a hydrogen atom, a methyl group or an aminomethyl group, the amino group being a dimethylamino, diethylamino, morpholino, 4-methyl-piperazino or piperidino radical; or R.sub.3 and R.sub.4 together denote a piperonylidene group; R.sub.5 denotes a hydrogen atom or a methyl group, and A forms, with the carbon atoms to which it is attached, a cyclopentane, cyclohexane, indane, tetrahydronaphthalene, perhydronaphthalene or piperidine structure and the pharmaceutically acceptable addition salts of the compounds containing an amino group.
    Type: Grant
    Filed: July 25, 1978
    Date of Patent: December 4, 1979
    Assignee: Unicler
    Inventor: Francois M. J. Vallet
  • Patent number: 4151291
    Abstract: The invention provides novel esters of 7-hydroxycoumarin of the formula ##STR1## in which each of R.sub.1 and R.sub.2 represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, carboxy, carboxylate, C.sub.2 -C.sub.5 alkoxycarbonyl or nitrophenyl group, and R.sub.3 represents a hydrogen atom or a group of the formula --CH.sub.2 --Z in which Z represents a di(C.sub.1 -C.sub.4 alkyl)amino group, or a saturated heterocyclic amino radical containing 5 to 7 ring members which may contain a further heteroatom, and their pharmaceutically acceptable acid addition salts. The compounds are useful as medicaments, in particular as analgesics.
    Type: Grant
    Filed: November 17, 1977
    Date of Patent: April 24, 1979
    Assignee: Unicler
    Inventor: Francois M. J. Vallet