Abstract: A method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and/or reducing infarct size is described which involves administering an effective amount of an anti-CD18 antibody to the mammal, in the absence of removal of the arterial obstruction.
Type:
Grant
Filed:
January 22, 1997
Date of Patent:
June 22, 1999
Assignees:
Genentech, Inc., Univ. of VT and State Agricultural College
Inventors:
Martin M. Bednar, Cordell E. Gross, G. Roger Thomas