Patents Assigned to Univeristät für Bodenkultur Wien
  • Production cell line
    Patent number: 8962277
    Abstract: The invention refers to a method of producing a recombinant polypeptide of interest (POI) in a cell culture, comprising genetically engineering a eukaryotic cell line—to specifically cause prolongation of the G2+M cell cycle phase in a pre-culture phase, and—to produce the POI in a producing phase following the pre-culture phase, a high producer cell line and cell culture as well as a method of increasing the yield of a recombinant POI production in a cell culture.
    Type: Grant
    Filed: July 4, 2011
    Date of Patent: February 24, 2015
    Assignee: Univeristät für Bodenkultur Wien
    Inventors: Diethard Mattanovich, Martin Dragosits, Brigitte Gasser, Michael Maurer, Michael Sauer