Abstract: A polyacrylamide-based copolymer reduces or prevents aggregation of biologic molecules including proteins, peptides, and nucleic acids, and lipid-based vehicles such as liposomes, lipid nanoparticles, polymerosomes, and micelles, in aqueous formulations at hydrophobic interfaces, thereby increasing the thermal stability of the molecules in the formulation. Methods and compositions comprising the copolymer and a protein or the copolymer and insulin can be used for treating conditions including diabetes.

Abstract: Certain disclosed embodiments concern a bioremediation composition comprising microbial cells, at least one co-metabolism substrate to induce selected enzyme production by the microbial cells, and a bead or gel encapsulating the microbial cells, such as bacterial or fungi cells, and the at least one co-metabolism substrate. For certain embodiments, the substrate is a slow release compound, such as an orthosilicate that hydrolyzes to produce an alcohol growth substrate. Embodiments of a method for using the composition to transform contaminants of concern also are disclosed.

Abstract: An optically-monitored and/or optically-controlled electronic device is described. The device includes at least one of a semiconductor transistor or a semiconductor diode. An optical detector is configured to detect light emitted by the at least one of the semiconductor transistor or the semiconductor diode during operation. A signal processor is configured to communicate with the optical detector to receive information regarding the light detected. The signal processor is further configured to provide information concerning at least one of an electrical current flowing in, a temperature of, or a condition of the at least one of the semiconductor transistor or the semiconductor diode during operation.

Abstract: Provided herein is a macroscope comprising an objective apparatus comprising a multifocal widefield optics comprising a plurality of optical components configured to focus on a plurality of planes. Also provided herein are methods for analyzing a three-dimensional specimen, the method comprising obtaining, via a macroscope, synchronous multifocal optical images of a plurality of planes of the three-dimensional specimen, wherein the macroscope comprises an objective apparatus comprising a multifocal widefield optics comprising a plurality of optical components configured to focus on a plurality of planes. The three-dimensional specimen can be a biological specimen, such as brain.

Abstract: An image restoration method, apparatus and device, and a storage medium are provided. The method comprises: evaluating, by an unsharpness evaluation network, an image to be processed, to generate an a feature map; inputting said image to be processed and the unsharpness feature map into a blur elimination main network; and iteratively processing, by the blur elimination main network, the image to be processed for a set number of times according to the unsharpness feature map to output a restored image. In the above-mentioned technical solution, an unsharpness feature of an image to be processed is extracted by using an unsharpness evaluation network, and iterative processing is performed on said image to be processed by using a blur elimination main network, where the networks are trained networks having corresponding functions, such that automatic restoration of an image can be realized, and image restoration efficiency and quality are improved.

Abstract: A particle matter analysis device, an analysis method and a manufacturing method are disclosed.

Abstract: Systems and methods described herein relate to reconstructing a scene in three dimensions from a two-dimensional image. One embodiment processes an image using a detection transformer to detect an object in the scene and to generate a NOCS map of the object and a background depth map; uses MLPs to relate the object to a differentiable database of object priors (PriorDB); recovers, from the NOCS map, a partial 3D object shape; estimates an initial object pose; fits a PriorDB object prior to align in geometry and appearance with the partial 3D shape to produce a complete shape and refines the initial pose estimate; generates an editable and re-renderable 3D scene reconstruction based, at least in part, on the complete shape, the refined pose estimate, and the depth map; and controls the operation of a robot based, at least in part, on the editable and re-renderable 3D scene reconstruction.

Abstract: A catalyst obtainable by exsolving particles of Ni, Co and/or a mixture of Ni and Co from a perovskite metal oxide of formula (I) (M1aM2b)(COxNiyM3z)O3, wherein M1 and M2 are each independently an alkali earth metal or a rare earth metal, M3 is Ti or Cr, 0?a?1, 0?b?1, 0<a+b?1, 0?x<1, 0?y<1, 0?z<1, x+y+z=1 and where at least one of x and y>0. The invention includes methods of converting this catalyst into one or more catalytically active forms. The catalysts and the activated forms of same are useful in the catalysing CO oxidation and/or NO oxidation.

Abstract: Methods, systems, and computer readable media for 3D printing from images, e.g., medical images or images obtained using any appropriate volumetric imaging technology. In some examples, a method includes receiving, from a medical imaging device, a multi-dimensional image of a structure. The method includes, for each two dimensional (2D) slice of the multi-dimensional image, converting, row-by-row for each row of the 2D slice, voxels of the 2D slice into 3D printing instructions for the 2D slice. The method includes 3D printing, by controlling a 3D printing extruder, a physical model based on the structure by 3D printing, slice by slice, each 2D slice using the 3D printing instructions.

Abstract: The subject invention provides compounds as antitoxins for mitigating the toxic effects of algal toxins, e.g., brevetoxins. These compounds are mercaptan based compounds and derivatives that react rapidly with such toxins, e.g., brevetoxins and can be used to treat poisoning in a subject caused by such toxins. The subject invention also provides compositions comprising the mercaptan based compounds and derivatives for use to mitigate the toxic effects of brevetoxins. Further provided are methods of using the mercaptan based compounds and derivatives and compositions for treating and/or preventing brevetoxin poisoning in a subject such a human and marine animal.

Abstract: Novel dinuclear silver(I) pyrazolido complexes and methods of synthesizing them are provided. Advantageously, the novel silver(I) pyrazolido complexes have excellent antimicrobial activity and methods of using said complexes to treat bacterial, fungal, and viral infections are also provided.

Abstract: A handle system includes a body extending between a first end and a second end. The handle system also includes a slot extending, at least partially, in the body, the slot forming a cavity. The handle system further includes a carrier arranged, at least partially, within the slot, the carrier further comprising a friction locker and at least one arm coupled to the friction locker, the at least one arm being rotatable about the friction locker. The handle system also includes a cap arranged on at least one of the first end or the second end. The handle system further includes a blade coupled to the at least one arm, the blade being rotatable about the axis between a retracted position where the blade is positioned within the slot and an extended position where the blade extends outwardly from the body.

Abstract: A series of bio-based benzoxazine monomers were developed. These benzoxazine monomers are liquid at room temperature with good processability due to their low viscosities at or near room temperature and their relatively low polymerization temperatures. Cured materials made from these bio-based benzoxazines have excellent thermal and mechanical properties.

Abstract: Disclosed are a method and apparatus for summarization of unsupervised video with efficient key frame selection reward functions. Frame-level visual features are extracted from an input video. An attention weight is computed and an importance score is represented as a frame tracking probability for selecting a key frame using the attention weight. A temporal consistency reward function and a representativeness reward function are obtained so as to select the key frame, based on a visual similarity distance and temporal distance between key frames, and an attention-based video summarization network is trained to predict an importance score for selecting a key frame of a video summary by using the temporal consistency reward function and the representativeness reward function.

Abstract: Synthetic antimicrobial peptides, compositions comprising thereof, and methods of use for modulating one or more symptoms of an infection in a subject are disclosed. In some aspects, the infection is caused by mycobacteria, for example, a nontuberculous mycobacterium such as Mycobacterium abscessus. In other aspects, the infection is caused by Escherichia coli, Pseudomonas aeruginosa, or methicillin-resistant Staphylococcus aureus (MRSA). Also disclosed are methods of identifying synthetic antimicrobial peptides against a pathogen with no known effective treatment using a library of synthetic peptides.

Abstract: The present disclosure provides a cuboid magnetometer with high fluorescence collection efficiency, used for cardiac magnetic field measurement, and based on nitrogen-vacancy (NV) centers in diamond, and a cardiac magnetic field measurement system. The cardiac magnetic field measurement system includes a magnetic shielding chamber, a non-magnetic bed, an array probe for cardiac magnetic field measurement, a three-axis displacement platform, a high-speed data collection card, a fiber laser source, a microwave source, and a computer. The array probe for cardiac magnetic field measurement includes a non-magnetic shell, a stepping motor, a porous rotary fiber coupling apparatus, a fiber bundle set, a special photodetector (PD) set, a filter set, a ring-shaped antenna, and special diamond.

Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Abstract: A diagnostic assay strip includes a first layer that includes an iron mobile labelled specific binding partner that will bind to and iron biomarker from a sample and produce an iron complex and a vitamin A mobile labelled specific binding partner that will bind to a vitamin A biomarker from the sample and produce a vitamin A complex. A second layer includes iron and vitamin A test regions, and a control region. The iron test region has immobilized specific binding partners that will bind to the iron complex. The vitamin A test region has immobilized vitamin A biomarker that will bind to vitamin A mobile labelled specific binding partner, which is not bound to the vitamin A biomarker, passing from the first layer to the second layer. The control region has a moiety which will non-specifically bind to and immobilize the iron and vitamin A labelled specific binding partners. Methods of using the diagnostic assay strip are also discussed.

Abstract: The present invention discloses a method for directly constructing highly optically active tetrasubstituted allenic acid compounds, i.e., a one-step process for directly constructing highly optically active axially chiral tetrasubstituted allenic acid compounds by using tertiary propargyl alcohol, carbon monoxide and water as reactants in an organic solvent in the presence of palladium catalyst, chiral diphosphine ligand, monophosphine ligand and organic phosphoric acid. The method of the present invention has the following advantages: operations are simple, raw materials and reagents are readily available, the reaction conditions are mild, the substrate has high universality, the functional group has good compatibility, and the reaction has high enantioselectivity (90%˜>99% ee).

Abstract: The present disclosure provides methods of preparing a biological specimen for imaging analysis, comprising fixing and clearing the biological specimen and subsequently analyzing the cleared biological specimen using microscopy. Also included are methods of quantifying cells, for example, active populations of cells in response to a stimulant. The present disclosure also provides devices for practicing the described methods. A flow-assisted clearing device provides rapid clearing of hydrogel-embedded biological specimens without the need of specialized equipment such as electrophoresis or perfusion devices.