Abstract: The invention relates to single-beam side deflectors with effective refractive indexes of respective channel and target film waveguides, a refractive index of the cladding and substrate, and a periodicity ? of the channel waveguide that satisfy the single-beam diffraction conditions. The invention also relates to wavelength multiplexers/demultiplexers, optical antenna feeders, and methods which use all of them.

Abstract: The invention relates to a waveguide and a polarisation splitter based on said waveguide, in which a rotation of an angle greater than zero is applied to a plurality of sections of a core material and a plurality of sections of a covering material, thereby achieving an independent control of the refractive indices of a zero-order transverse electric mode and a zero-order transverse magnetic mode. This document also describes a manufacturing method of said waveguide which allows the birefringence of the light that passes through the waveguide.

Abstract: A bricked sub-wavelength periodic waveguide and a modal adapter, power divider and polarization splitter that use the waveguide. The waveguide includes blocks disposed periodically with a period “Lz” on a substrate and which alternate with a covering material. The first blocks have a width “ax” and the second blocks have a width “bx”, alternating on the substrate according to a period “Lx”, the second blocks being shifted a distance “dz” the first blocks in the direction of propagation. A modal adapter, a power divider and a polarization splitter all use the periodic waveguide and can operate with larger wave periods without leaving the sub-wavelength regime.

Abstract: The invention relates to a waveguide and a polarisation splitter based on said waveguide, in which a rotation of an angle greater than zero is applied to a plurality of sections of a core material and a plurality of sections of a covering material, thereby achieving an independent control of the refractive indices of a zero-order transverse electric mode and a zero-order transverse magnetic mode. This document also describes a manufacturing method of said waveguide which allows the birefringence of the light that passes through the waveguide.

Abstract: The invention relates to an integrated polarisation splitter based on a sub-wavelength multimode interference coupler (110), in other words, a multimode interference coupler (110) with an anisotropic multimode waveguide region formed by a plurality of sections of core material (210) and a plurality of sections of a cladding material (230) alternately arranged in a periodic way, with a period (?) smaller than the wavelength of a light propagated through said anisotropic region. The core material sections (210) are rotated an angle (?) greater than zero with respect to a perpendicular with an input waveguide (120) to increase the anisotropic character of the multimode waveguide region.

Abstract: The invention relates to a recombinant protein and uses thereof in the diagnosis and treatment of multiple sclerosis. The invention also relates to the recombinant protein IFNAR2.3, antibodies, compositions comprising same, and uses thereof. Among the uses thereof, the invention especially relates to a method for the diagnosis of multiple sclerosis, and to the diagnosis kit. The invention further relates to the use of the protein IFNAR2.3 in the preparation of a medicament for the treatment of multiple sclerosis.

Abstract: A tool coupling includes a first tool part and a second tool part, the second tool part being movable in relation to the first tool part. The tool coupling further includes a first base part for detachably retaining the first tool part and a second base part movable in relation to the first base part for detachably retaining the second tool part. The first base part has a pusher movable in relation to the first base part for detaching the first tool part and the second base part has a cap movable in relation to the second base part for detaching the second tool part.

Abstract: The invention relates to the field of oncology and cancer treatment. The invention relates to methods for predicting the risk of recurrence of breast tumors using the expression signature of particular miRNAs. Specifically, the invention relates to a method for determining the risk of recurrence of breast cancer which comprises measuring the expression levels of at least one miRNA selected from the group consisting of miR-149-5p (SEQ ID NO: 1), miR-10a-5p, (SEQ ID NO: 2), miR-20b-5p, (SEQ ID NO: 3), miR-30a-3p (SEQ ID NO: 4), and miR-342-5p, (SEQ ID NO: 5) in a sample of the tumor, wherein a change in the expression level of at least one miRNA in the tumor with respect to the expression level in a control sample is indicative of a high risk of recurrence of the tumor. The invention also relates to tools and kits for carrying out the method of the invention.

Abstract: The invention refers to a method, and to a device to produce emulsions and particle suspensions by using electro-hydrodinamic forces and microfluidics This combined use allow the production of droplets with mean diameters which may be either smaller than those obtained in conventional microfluidic devices or larger than those obtained by electrospray, bridging the gap between the two methods acting independently.

Abstract: The invention relates to an automobile braking system with grip prediction and continuous control of braking pressure, including a hydraulic circuit which regulates braking pressure by controlling a proportional pressure value (8) which maintains the necessary pressure on the brake piston (6) in order to perform suitable braking. Braking control is permanently performed by a control system capable of recognizing actual grip conditions at all times and of establishing the ideal pressure conditions on the braking piston (6), said pressure being under optimal control at all times, ensuring that none of the wheels of the vehicle are subject to excessive skidding. Automobile braking can also be performed manually when the value (4) is in a standby position or in the event of a malfunction of the automatic braking control.

Abstract: The invention relates to a method of producing nanotubes from coaxial jets of immiscible liquids or poorly-miscible liquids. The purpose of the invention is to produce hollow fibers (nanotubes) or composite fibers having diameters ranging from a few micras to tens of nanometers and comprising walls, in the case of nanotubes, with a thickness ranging from hundreds of nanometers to a few nanometers. The inventive nanotube-formation method involves the generation of coaxial nanojets of two liquids using electrohydrodynamic technology.

Abstract: Robotic system for assisting in minimally-invasive surgery, which can position a surgical instrument in response to orders from a surgeon, is not attached to the operating table and does not require pre-calibration of the insertion point. The system includes: a manipulator robot having three active degrees of freedom, which is provided with an end actuator having two passive degrees of freedom, said actuator being used to attach a surgical instrument; a robot controller built into the structure thereof, which can perform a method for calculating the movement to be imparted to the carried surgical instrument so that it reaches the desired location without requiring pre-calibration and without the assembly having to be attached to the operating table; and an interface system for ordering the system to perform the desired actions. The assembly comprising the robot, the controller and the interface system is battery operated.