Patents Assigned to Universita Degli Studi Di Milano, Bicocca
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Publication number: 20240110931Abstract: The present disclosure relates to delta-2-tubulin and its use as a biomarker for determining if a subject is at risk of developing peripheral neuropathy or if a subject has developed peripheral neuropathy. The present disclosure further relates to methods for the treatment of peripheral neuropathy in a subject and assays for identifying compounds that can be used to treat and/or prevent peripheral neuropathy.Type: ApplicationFiled: December 5, 2023Publication date: April 4, 2024Applicants: The Trustees of Columbia University in The City of New York, Università Degli Studi Di Milano-BicoccaInventors: Francesca Bartolini, Maria Elena Pero, Guido Cavaletti
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Patent number: 11906437Abstract: A spectroscopic analysis apparatus may include: a sample holder to retain a gem in analysis position; a first light source configured to emit a first primary beam at an excitation wavelength toward the analysis position to generate emission or diffusion of light; a second light source configured to emit a second primary beam comprising UV light toward the analysis position to impact on the first side; an optical focusing system to focus the light emitted or diffused by the first side in a secondary optical beam; a spectral dispersion device arranged to collect and spatially disperse the secondary optical beam; a first photodetector device arranged to collect the dispersed light and to output a distribution of spectral intensity as a function of emission wavelength; a second photodetector device to collect visible light transmitted through the gem; and a film of fluorescent material to UV light.Type: GrantFiled: December 20, 2018Date of Patent: February 20, 2024Assignee: Università degli Studi di Milano - BicoccaInventors: Roberto Lorenzi, Alberto Maria Felice Paleari, Andrea Zullino
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Patent number: 11874284Abstract: The present disclosure relates to delta-2-tubulin and its use as a biomarker for determining if a subject is at risk of developing peripheral neuropathy or if a subject has developed peripheral neuropathy. The present disclosure further relates to methods for the treatment of peripheral neuropathy in a subject and assays for identifying compounds that can be used to treat and/or prevent peripheral neuropathy.Type: GrantFiled: May 27, 2020Date of Patent: January 16, 2024Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCAInventors: Francesca Bartolini, Maria Elena Pero, Guido Cavaletti
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Patent number: 11697831Abstract: Disclosed is the production by fermentation of poly D-lactic acid (PDLA) and poly L-lactic acid (PLLA). In particular, there is provided engineered (prokaryotic or eukaryotic) cells for the direct synthesis of PLLA polymers and engineered eukaryotic cells for the direct synthesis of PDLA polymers starting from a carbon source, including residual biomasses of the different production chains.Type: GrantFiled: July 31, 2019Date of Patent: July 11, 2023Assignees: UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA, GALATEA BIOTECH S.R.L.Inventors: Danilo Porro, Paola Branduardi, Stefano Bertacchi, Nadia Maria Berterame
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Patent number: 11613863Abstract: A device for simulating injections of liquid chemical/cementitious substances into soils, comprising a first observation chamber which delimits an injectable space adapted to accommodate a soil sample, a second observation chamber which delimits a perforation space adapted to accommodate at least one stretch of an injection device, with longitudinal extension along a longitudinal axis of the second observation chamber, wherein the first observation chamber and the second observation chamber are directly bordering to each other in an interface area, a retaining partition wall which can be inserted in the interface area so as to separate the injectable space from the perforation space and extracted so as to put the perforation space into communication with the injectable space, as well as first transparent portions formed in a first containment wall of the first observation chamber for viewing in real time a propagation of the chemical substance injected into the soil sample by means of the injection device.Type: GrantFiled: February 12, 2019Date of Patent: March 28, 2023Assignees: UNIVERSITÁ DEGLI STUDI DI MILANO-BICOCCA, SIREG GEOTECH S.R.L., STUDIO ING. ANDREA PETTINAROLI S.R.L.Inventors: Riccardo Castellanza, Stefania Zenoni, Gabriele Balconi, Andrea Maria Romildo Pettinaroli
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Publication number: 20220390627Abstract: A sensitized composite scintillator which optionally interacts with ionizing radiation is provided having a vitreous or plastic matrix in which there are incorporated perovskite nanostructures which sensitize light emitters.Type: ApplicationFiled: November 3, 2020Publication date: December 8, 2022Applicants: UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA, GLASS TO POWER S.P.A.Inventors: Sergio BROVELLI, Mauro FASOLI, Luca GIRONI, Marina GANDINI, Anna VEDDA
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Publication number: 20220313607Abstract: The present invention relates to a liposome containing a lipid or lipid mixture, phosphatidic acid and/or cardiolipin and apolipoprotein E for use in the treatment and/or prevention of amyloidosis, wherein the amyloidosis is not Alzheimer's disease and pharmaceutical compositions containing the same.Type: ApplicationFiled: July 31, 2020Publication date: October 6, 2022Applicant: UNIVERSITÀ DEGLI STUDI DI MILANO - BICOCCAInventors: Francesca RE, Massimo Ernesto MASSERINI, Marco Antonio Ercole SARDINA
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Publication number: 20220162611Abstract: The present invention relates to an inhibitor of miR-129, relative compounds and pharmaceutical compositions for use in the treatment and/or prevention of amyotrophic lateral sclerosis and Alzheimer's disease. The invention also relates to a method for the diagnosis and/or prognosis of Alzheimer's disease in a subject or to identify a subject at risk to develop amyotrophic lateral sclerosis or Alzheimer's disease and to a method for the measuring the efficacy of a therapy for amyotrophic lateral sclerosis or for Alzheimer's disease and relative kits.Type: ApplicationFiled: March 26, 2020Publication date: May 26, 2022Applicants: UNIVERSITÀ DEGLI STUDI DI MILANO BICOCCA, FONDAZIONE IRCCS "CA' GRANDA - OSPEDALE MAGGIORE" POLICLINICOInventors: Stefania CORTI, Silvia Maria Luisa BARABINO, Monica NIZZARDO, Alessia LOFFREDA
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Patent number: 11273023Abstract: An implantable medical device obtained by means of two-photon laser polymerisation of a resin to form a three-dimensional matrix, wherein: said three-dimensional matrix comprises a number of levels distributed in height; and said three-dimensional matrix comprises reference means designed to uniquely identify the height of each level from a pre-set reference, by means of a multi-photon fluorescence-excitation microscope; said implantable medical device being characterised in that said reference means comprise a solid having a cross section that varies with height.Type: GrantFiled: December 18, 2018Date of Patent: March 15, 2022Assignees: POLITECNICO DI MILANO, UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA, CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Manuela Teresa Raimondi, Giulio Cerullo, Claudio Conci, Tommaso Zandrini, Roberto Osellame, Giuseppe Chirico
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Publication number: 20210399152Abstract: A glass brick having a luminescent solar concentrator inserted inside it, between the preformed glass portions which constitute the body of the glass brick is provided.Type: ApplicationFiled: October 28, 2019Publication date: December 23, 2021Applicants: UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA, GLASS TO POWER S.P.A.Inventors: Francesco MEINARDI, Sergio BROVELL, Francesco BRUNI, Marina GANDINI, Emillo SASSONE CORSI, Graziella GARIANO, Chiara CAPITANI
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Publication number: 20210388666Abstract: An insulating glazing having at least two panels made of transparent or semi-transparent material is provided. At least one of these panels is a luminescent solar concentrator.Type: ApplicationFiled: October 28, 2019Publication date: December 16, 2021Applicants: UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA, GLASS TO POWER S.P.A.Inventors: Francesco MEINARDI, Sergio BROVELLI, Francesco BRUNI, Marina GANDINI
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Patent number: 11041270Abstract: Process for the plasma surface treatment under vacuum of a fabric, nonwoven fabric or paper material for obtaining materials to be used for the filtration and separation of two immiscible liquids.Type: GrantFiled: May 3, 2017Date of Patent: June 22, 2021Assignee: Universita' degli Studi Di Milano-BicoccaInventors: Claudia Riccardi, Stefano Zanini
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Publication number: 20210052723Abstract: The present invention relates to new synthetic molecules with agonist activity of human Toll-like Receptor 4 (TLR4), compositions comprising them and uses thereof for the treatment of diseases in which it is useful to induce or increase an immune response. The compounds have general formula (1), wherein R1 is a saturated C8-C16 aliphatic chain having a =0 on C1, said chain being free from —OH substituents on C3, wherein R2 is a saturated C8-C16 aliphatic chain having a ?O on C1, said chain being free from —OH substituents on C3, wherein R3 is a saturated C8-C16 aliphatic chain having a ?O on C1, said chain being free from —OH substituents on C3; wherein R4 is a hydrogen atom (H) or a phosphate group (PO42?).Type: ApplicationFiled: November 5, 2018Publication date: February 25, 2021Applicant: UNIVERSITA DEGLI STUDI DI MILANO - BICOCCAInventors: Francesco PERI, Alberto MINOTTI
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Publication number: 20200362507Abstract: Process for the plasma surface treatment under vacuum of a fabric, nonwoven fabric or paper material for obtaining materials to be used for the filtration and separation of two immiscible liquids.Type: ApplicationFiled: May 3, 2017Publication date: November 19, 2020Applicant: Universita' degli Studi Di Milano-BicoccaInventors: Claudia Riccardi, Stefano Zanini
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Publication number: 20200333359Abstract: The present disclosure relates to delta-2-tubulin and its use as a biomarker for determining if a subject is at risk of developing peripheral neuropathy or if a subject has developed peripheral neuropathy. The present disclosure further relates to methods for the treatment of peripheral neuropathy in a subject and assays for identifying compounds that can be used to treat and/or prevent peripheral neuropathy.Type: ApplicationFiled: May 27, 2020Publication date: October 22, 2020Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCAInventors: Francesca Bartolini, Maria Elena Pero, Guido Cavaletti
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Publication number: 20200157418Abstract: Disclosed are a colloidal coating dispersion containing electrochromic polymer particles, a method for manufacturing the colloidal coating dispersion, the use of the colloidal coating dispersion for depositing at least one electrochromic layer on a substrate, and an article including a layer deposited from the colloidal coating dispersion.Type: ApplicationFiled: November 8, 2019Publication date: May 21, 2020Applicants: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E. V., Università degli Studi di Milano - BicoccaInventors: Sven MACHER, Uwe POSSET, Luca BEVERINA, Mauro SASSI, Marco SCHOTT
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Patent number: 10644303Abstract: It is described a method for realizing catalytically active electrochemical electrodes with maximized surface area. In the method, InGaN is deposited epitaxially in form of a thin layer on a Silicon substrate exposing a (111) crystal fac, thus forcing the InGaN electrode material to grow exposing a catalytically active surface. The substrate is then removed, the InGaN layer is made into fragments and these are transferred onto a conductive support with one-, two- or three-dimensional structure which can be a wire, a two-dimensional conductive foil which, possibly folded, or a three-dimensional conductive fabric, sponge or cage-like structure. It is thus possible to obtain an InGaN-based electrode with increased surface area and exposing surfaces with high catalytic activity.Type: GrantFiled: March 14, 2017Date of Patent: May 5, 2020Assignee: UNIVERSITÁ DEGLI STUDI DI MILANO BICOCCAInventors: Richard Noetzel, Stefano Sanguinetti
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Publication number: 20200095387Abstract: The present invention regards a solid master elastomeric composition (masterbatch, MB) comprising silicate fibres with needle-shaped morphology of nanometric size, characterised by high fibre content and uniformity, a process advantageous for the preparation thereof and its use in manufacturing tyres for vehicles. Advantageously the present elastomeric composition allows minimising the drawbacks associated with the handling of the powdery fibres in the manufacturing of compounds for tyres, without altering the final performances thereof.Type: ApplicationFiled: December 18, 2017Publication date: March 26, 2020Applicants: PIRELLI TYRE S.p.A., POLITECNICO DI MILANO, UNIVERSITA' DEGLI STUDI DI MILANO BICOCCAInventors: Luciano TADIELLO, Valeria Rosaria CIPOLLETTI, Luca GIANNINI, Thomas HANEL, Maurizio GALIMBERTI, Roberto SCOTTI, Barbara DI CREDICO, Franca MORAZZONI, Massimiliano D'ARIENZO, Irene TAGLIARO
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Patent number: 10143969Abstract: The present invention relates to novel molecules suitable to the use in the separation/removal of carbon dioxide from gaseous mixtures as liquid-phase carbon dioxide absorbers and suitable to allow the subsequent release of the absorbed carbon dioxide in form of different ionic liquids, preferentially a glycine salt with choline hexanoate, ester between glycine and hexanoic alcohol (hexyl glycinate) and glycerol ester with glycine and hexanoic acid. The present invention also relates to a method and a plant for the capture of carbon dioxide from gaseous mixtures by using an absorber for carbon dioxide in liquid phase with a heating jacket.Type: GrantFiled: January 16, 2015Date of Patent: December 4, 2018Assignee: UNIVERSITA DEGLI STUDI DI MILANO-BICOCCAInventors: Maurizio Filippo Acciarri, Simona Olga Binetti, Bruno Vodopivec, Maurilio Giuseppe Meschia
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Patent number: 10010505Abstract: New liposomes are described, comprising: (i) phosphatidic acid and/or cardiolipin; (ii) apolipoprotein E (ApoE) or derivatives thereof. The so modified liposomes, administered systemically, obtain a dramatic in-vivo reduction of the amyloid plaque in the central nervous system, allowing an effective treatment of neurodegenerative diseases, in particular Alzheimer's disease.Type: GrantFiled: October 2, 2014Date of Patent: July 3, 2018Assignee: UNIVERSITA DEGLI STUDI DI MILANO-BICOCCAInventors: Massimo Masserini, Francesca Re, Giulio Sancini, Gianluigi Forloni, Mario Salmona