Abstract: A determination of supramolecular organization in a substance includes target molecules and nanocarriers at least one of which is luminescent, based on a step of collecting of lifetime decay data of at least a standard substance pure or substantially pure where a known organization state of the target molecules and the nanocarriers is pure or substantially pure; and a step of comparing the standard data and test data from a test substance.

Abstract: In a method for manufacturing prestressed shells having tunable bistability, in order to determine the appropriate prestress to be applied to the bistable structure/shell, it provides: clamping a shell by applying a predetermined curvature on a portion of its edge; defining a discrete shell model dependent on a small number of configuration parameters q_i, (i<5), by projecting the non-linear shell model of Marguerre-von Kármán onto an appropriate finite dimensional space so that the projection does not significantly alter the strain elastic energy; tracing the stability maps in the space of the design parameters by minimizing the discrete representation of the strain elastic energy E(q_i;p_i) thus obtained; and choosing the design parameters providing the prestress needed to obtain the desired response in terms of project requirements.

Abstract: An aqueous composition comprising chitosan and fibroin nanoparticles, with a diameter equal or lower than 140 nm, and an acid agent, with pH equal or lower than 6, and viscosity equal or lower than 3.5 kg×m?1×s?1 measured at 25.0±0.1° C., kit and method for finishing and/or preservation and/or restoration and/or renovation and/or repairing and/or consolidation of manufactures, in particular ancient manufactures are disclosed.

Abstract: miRNAs for in vitro diagnosis of resistance of tumors to BRAF/MEK pathway (also named as MAPK 5 pathway) inhibiting drugs and for treatment of tumors which are treated with said drugs, such as melanoma, by stimulating or inhibiting the expression of down-regulated or up-regulated miRNAs, respectively.

Abstract: Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).

Abstract: The method of the invention envisages estimation and learning of the state of the system using the data traffic of the network itself, with co-ordination of a node, selected as collector, which, in addition to its normal data-collection role, determines and changes dynamically the network-protocol stack used, for optimizing the performance of interest, where for this purpose said node, with a processing unit thereof, implements a computer program referred to as “protocol selector”, which: executes monitoring of the network state and collection of the data on the performance of the network itself; evaluates at periodic intervals the performance of the protocol in the last interval and executes a step of a reinforcement-learning algorithm at the end of which it evaluates whether to change or not the protocol for the next interval and resumes the main execution flow.

Abstract: An echo-scintigraphic probe for medical applications and the method of merging images. It is constituted by the union of an ultrasound probe suitably integrated, both in geometric terms, and in terms of image processing, with a scintigraphic probe or gamma camera (3). With a single application of said probe, one is able to provide a double image of the object under examination. The ultrasound probe is housed in the head, above the plane of the collimator and kept projecting to favor the direct contact with the body part of the patient to be examined. The collimator is able to obtain images of the biodistribution of a radiolabelled drug by radiation with frontal incidence, maintaining the characteristics of the ultrasound probe. The probe is applicable to both clinical diagnosis and intraoperative diagnosis of cancer with the use of radio tracers.

Abstract: Disclosed is a dental adhesive including a polymeric adhesive and a nanofiller dispersed in the polymeric adhesive, the nanofiller being constituted by graphene nanostructures which are properly dispersed inside the polymer adhesive and over the surface of the adhesive layer without formation of agglomerates, so that the dental adhesive exhibits significant antimicrobial and antibiofilm properties against pathogens of the oral cavity.

Abstract: A multi-performance hysteretic rheological device. The invention concerns a mechanical device capable of providing restoring forces with non-linear hysteresis loops whose shapes can be adjusted depending on the specifications required by the application. The forces exerted on rigid sliding blocks on smooth bars are for example produced by the wire ropes composed of steel and shape-memory material wires. The device according to the invention can be used in very different applications including: vibration damper, hysteretic insulator, energy absorber, shock absorber, applications in which a specific rheological body with force-displacement characteristics of hysteretic type is required.

Abstract: The method of the invention envisages determining, for each packet that is to be transmitted/retransmitted, through an LLC communication protocol, which is the top sublayer of the datalink layer of the ISO-OSI model, (LLC logic) autonomously, node by node, the specific communication apparatus to be used from the ones available on the single node, to which subset of the nodes said packet is to be transmitted (routing logic), i.e., the number and the set of neighbouring nodes to which it is to be transmitted, the specific communication apparatus to be used from the multiple ones that may be available, and the maximum number of retransmissions to be made, by using a decentralized self-learning algorithm that enables each node to learn and select dynamically the best operating mode, according to the number of transmissions already made.

Abstract: The present invention relates to a structural element known in the technical field as “tensairity”, which introduces as distinctive elements with respect to the known art: (i) ropes in the shape-memory alloy (SMA) with superelastic (SE) and shape memory (ME) behavior; (ii) mechanical tensioners for the adjustment of the initial tension in the ropes; (iii) optionally a control apparatus (processor) is connected to electric circuits that induce flow of intensity variable current through the SMA wire ropes; (iv) optionally devices for real-time monitoring of the temperature and the level of tension in the SMA ropes; (v) optionally devices for real-time monitoring of the tensairity oscillations; (vi) optionally new structural geometries capable of sustaining static actions and multidirectional dynamics.

Abstract: The present invention concerns a nucleic acid molecule capable of expressing, in at least one plant tissue, a chimeric protein comprising a polygalacturonase (PG) of fungal, bacterial or insect origin and a plant polygalacturonase inhibitor protein (PGIP) plant capable of inhibiting said PG. The present invention also relates to transgenic plants that express said chimeric protein.

Abstract: The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB).

Abstract: A method of processing a computing task required by wireless equipment of a cellular communication network, including classifying the task in at least one class of immediate offloaded execution and a class of immediate local execution, by traversing oriented graph decision nodes and terminal nodes each assigned to one of the classes, the decision nodes being distributed into at least three hierarchical levels themselves distributed into at least three subsets of levels. Traversal of the graph includes: during transit through any decision node of a first subset of levels, verification of a feasibility criterion for the offloading of the task for execution by third-party equipment; during transit through any decision node of a second subset of levels, verification of a criticality criterion for execution of the task, and during transit through any decision node of a third subset of levels, verification of an opportunity criterion for execution of the task.

Abstract: The present invention relates to the use of keratinocyte growth factor (KGF/FGF7) and pharmaceutical compositions thereof in the treatment of vaginal atrophy, dysuria, vaginal pain and/or vaginal dryness induced by a post-menopausal state, by surgical intervention, by illness and/or by chemotherapy or radiotherapy treatments.

Abstract: A device for connecting the elastic elements and dissipaters of variable type of a mechanical suspension interposed between two vibrating or tilting mechanical systems, the source body and the receiving body, respectively, in order to reduce the forces acting on the receiving body, and/or the displacement thereof, and/or the speed thereof, or combinations of the previous physical magnitudes and/or of any other ones, which are produced on the receiving body due to the motion or forces to which the source is subjected.

Abstract: A process for producing GNP-based polymeric nanocomposites for electromagnetic applications such as shielding and/or absorption of the energy associated to electromagnetic fields envisages a plurality of steps that include: controlled synthesis, for optimizing the morphological and electrical properties thereof, of graphene nanoplatelets (GNPs) to be used as nanofillers in a polymeric matrix; selection of the polymeric matrix so as to optimize its chemical compatibility with the type of GNPs thus obtained; production via the solution-processing technique of GNP-based polymeric nanocomposites with dielectric permittivity and electric conductivity controlled and predictable via the equivalent-effective-medium model by calibrating the parameters of the model for the specific type of polymeric matrix and GNPs used.

Abstract: The damping device comprises a cluster of resonators with a predetermined frequency distribution, that, when attached to a main or ‘master’ structure, is capable of absorbing irreversibly its vibrational or/and acoustic energy produced by a vibrating body. the density of natural frequencies of the plurality of resonators is comprised within a curve that lies below the envelope curve determined by the formula, e( )=1/?1.

Abstract: The present invention relates to a construct able to express in at least one plant tissue, a chimeric receptor, said chimeric receptor being essentially made of the extracellular region, comprising the external juxtamembrane portion, of a first kinase receptor R1; and the transmembrane region and the intracellular region, comprising the internal juxtamembrane portion, of a second kinase receptor R2, wherein R1 and R2 are different and uses thereof.

Abstract: The invention relates to the therapy of Duchenne Muscular Dystrophy (DMD) by means of modulating the amount of a specific miRNA (miR-31).