Patents Assigned to Universite Claude Bernard Lyon 1
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Publication number: 20220348587Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing the compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.Type: ApplicationFiled: June 3, 2022Publication date: November 3, 2022Applicants: CENTRE LEON BERARD, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Toufic RENNO, Isabelle COSTE-INVERNIZZI, Stéphane GIRAUD, Serge LEBECQUE
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METHOD AND DEVICE FOR ANALYSING A SAMPLE USING A RESONANT SUPPORT, ILLUMINATED BY INFRARED RADIATION
Publication number: 20220317031Abstract: A method for analysing a sample uses a resonant support. The sample extends on the support having a surface on which a plurality of separated photonic crystals extend. The sample extends between a light source and the crystals, wherein a resonance wavelength is associated with each crystal addressing the analyte and the wavelengths of the crystals define a resonance spectral band extending between 2 ?m and 20 ?m. The transmission or reflection of light by each crystal addressing the analyte is maximum at the associated resonance wavelength. The method includes illuminating the support by the light source, the light source emitting an illumination lightwave defining an illumination spectral band which at least partially covers the resonance spectral band, such that a plurality of crystals are simultaneously illuminated; acquiring an image of the support, and then determining the presence of the analyte in the sample from the image.Type: ApplicationFiled: June 4, 2020Publication date: October 6, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CPE LYON FORMATION CONTINUE ET RECHERCHE, ECOLE CENTRALE DE LYON, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVESInventors: Mathieu DUPOY, Maryse FOURNIER, Taha BENYATTOU, Cécile JAMOIS, Lotfi BERGUIGA, Nicolas GAIGNEBET, Thomas GEHIN -
Publication number: 20220317028Abstract: A method for analysing a sample uses a resonant support having a surface on which a plurality of separated photonic crystals extends. At least two crystals are configured to capture the same analyte. A resonance wavelength associated with each crystal varies with an amount of analyte in contact with the crystal. The wavelengths define a resonance spectral band between 200-1500 nm. The transmission/reflection of the light is maximum at an associated resonance wavelength. The method includes: illuminating the support in the resonance spectral band, the intensity of the lamination being variable in band; acquiring a measurement image using an image sensor, the image having different regions-of-interest each optically coupled to a photonic crystal; using a reference image representative of an image acquired by the image sensor, when the support is illuminated in the resonance spectral band in a reference configuration; and comparing the measurement image with the reference image.Type: ApplicationFiled: June 4, 2020Publication date: October 6, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CPE LYON FORMATION CONTINUE ET RECHERCHE, ECOLE CENTRALE DE LYON, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, AVALUN, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Mathieu DUPOY, Taha BENYATTOU, Lotfi BERGUIGA, Jean-Marc FEDELI, Maryse FOURNIER, Nicolas GAIGNEBET, Cecile JAMOIS, Patrick POUTEAU
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Publication number: 20220305480Abstract: A process for preparing a catalyst material, includes: (a) providing a support material having surface hydroxyl (OH) groups, the support material is ceria (CeO2), zirconia (ZrO2) or a combination, and the support material contains between 0.3 and 2.0 mmol OH groups/g of the support material; (b) reacting the support material with at least one of: (b1) a compound containing at least one alkoxy or phenoxy group bound though its oxygen atom to a metal element from Group 5 (V, Nb, Ta) or Group 6 (Cr, Mo, W); (b2) a compound containing at least one hydrocarbon group bound though a carbon atom to a metal element from Group 5 or 6; (b3) a compound containing at least one hydrocarbon group bound though a carbon atom to a metal element which is copper (Cu); and (c) calcining the product obtained in step (b).Type: ApplicationFiled: June 4, 2019Publication date: September 29, 2022Applicants: TOYOTA MOTOR EUROPE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1, ECOLE SUPERIEURE DE CHIMIE PHYSIQUE ELECTRONIQUE DE LYONInventors: Phuc Hai NGUYEN, Nicolas MERLE, Marc-Olivier CHARLIN, Kai Chung SZETO, Mostafa TAOUFIK
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Publication number: 20220305464Abstract: A process for preparing a catalyst material, includes the steps of: (a) providing a support material having surface hydroxyl (OH) groups, wherein the support material is ceria (CeO2), zirconia (ZrO2) or a combination of thereof; (b) reacting the support material having surface hydroxyl (OH) groups of step (a) with a precursor containing two transition metal atoms, each chosen independently from the group consisting of: W, Mo, Cr, Ta, Nb, V, Mn; (c) calcining the product obtained in step (b) in order to provide a catalyst material showing dual site surface species containing pairs of transition metal atoms derived from the precursor that are present in oxide form on the support material. Additionally, a catalyst material is obtained by the process set out above, and the catalyst material is used as an ammonia selective catalytic reduction (NH3-SCR) catalyst for nitrogen oxides (NOx) reduction.Type: ApplicationFiled: June 4, 2019Publication date: September 29, 2022Applicants: TOYOTA MOTOR EUROPE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1, ECOLE SUPERIEURE DE CHIMIE PHYSIQUE ELECTRONIQUE DE LYONInventors: Phuc Hai NGUYEN, Marc-Olivier CHARLIN, Cherif LARABI, Kai Chung SZETO, Mostafa TAOUFIK
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Patent number: 11440932Abstract: The present invention relates to a compound of formula (I): (I) as defined in the description. The present invention also relates to a method for extracting biological membrane-associated membrane proteins, comprising a step of bringing an aqueous solution of biological membrane-associated membrane proteins into contact with at least one compound of the invention. The present invention also relates to a method for stabilizing membrane proteins in solution in an aqueous solution, comprising a step (i) consisting in bringing an aqueous solution of a membrane protein in solution into contact with at least one compound of the invention.Type: GrantFiled: December 27, 2017Date of Patent: September 13, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1, UNIVERSITE GRENOBLE ALPESInventors: Pierre Falson, Julien Dauvergne, Ahcène Boumendjel, Marine Peuchmaur, Kim Anh Nguyen, Sandrine Magnard
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Publication number: 20220267289Abstract: A compound of formula (I): or pharmaceutically acceptable enantiomer, salt or solvate thereof, or a mixture thereof, the ring A, and the substituents Z, Y and R1 being as defined herein.Type: ApplicationFiled: June 1, 2020Publication date: August 25, 2022Applicants: UNIVERSITE GRENOBLE ALPES, CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Ahcène BOUMENDJEL, Pierre FALSON, Alexis MORENO, Basile PERES, Emile ROUSSEL
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Publication number: 20220259661Abstract: A kit for in vitro measurement of a at least one IL7R gene transcript in a blood sample, including specific reagents for measuring the transcript, and a control sample calibrated to contain the IL7R gene transcript corresponding to the mean quantity measured in a pool of reference blood samples from human patients in a state of septic shock when reference blood samples are taken, or who were in a state of septic shock within 72 h after taking the reference blood samples, and who were known to have survived, and/or a calibrated to contain the quantity of an IL7R gene transcript corresponding to the mean quantity measured in reference blood samples from patients in a state of septic shock when the reference blood samples are taken, or who were in a state of septic shock within 72 h after taking the reference blood samples, and not to have survived.Type: ApplicationFiled: April 26, 2022Publication date: August 18, 2022Applicants: BIOMERIEUX, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Elisabeth CERRATO, Benjamin DELWARDE, Guillaume MONNERET, Estelle PERONNET, Julien TEXTORIS, Fabienne VENET
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Patent number: 11390643Abstract: The present invention relates to a modified oligonucleotide having two or more thiol functions, which can be immobilized on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or carbon-carbon triple bond or haloacetamide functions, preferably maleimide or acrylamide functions. The invention also relates to a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridization between a modified oligonucleotide and a target nucleic acid amplified from the biological sample. The invention relates more particularly to a method for detecting, genotyping or sequencing a pathogenic organism, preferably a virus.Type: GrantFiled: February 8, 2019Date of Patent: July 19, 2022Assignees: ETABLISSEMENT FRANÇAIS DU SANG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE MONTPELLIER, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Chantal Fournier-Wirth, Myriam Lereau, Jean-François Cantaloube, Jean-Jacques Vasseur, François Morvan, Albert Meyer, Julie Mayen, Carole Chaix, Carole Farre
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Patent number: 11389793Abstract: The present invention relates to a method for producing a microfluidic device, in particular, a sol-gel method for producing a microfluidic device in hybrid silica glass. The invention also relates to a microfluidic device obtainable by the method as described above and to microfluidic device in hybrid silica glass comprising at least one microchannel having a depth of at least 1 ?m, preferably between 1 ?m and 1 mm, and more preferably between 10 and 100 ?m.Type: GrantFiled: September 8, 2017Date of Patent: July 19, 2022Assignees: TOTAL SA, ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Michael Levant, Denis Bartolo, Stéphane Parola, Denis Chateau
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Publication number: 20220220027Abstract: The invention relates to a method for depositing metal particles on a textile support, which comprises: placing at least one textile sheet (1) made of side-emitting optical fibers (2) in contact with a solution containing at least one ionic precursor of a metal to be deposited, the textile sheet (1) being formed from optical fibers (2) woven in warp and/or weft with binding threads in warp and/or weft, each of the optical fibers (2) having invasive alterations (5) along the fiber and allowing the emission of light propagating in the fiber at these alterations (5), the textile sheet (1) being coated on all or part of the surfaces thereof with a layer of semiconductor particles (4) having photocatalytic properties, the textile sheet (1) and the solution being contained in a space of a reactor (9), the space being free of oxygen; illuminating the textile sheet (1) by at least one light source (7) connected to all or part of the free ends (6) of the optical fibers (2), the light source generating light radiatiType: ApplicationFiled: May 5, 2020Publication date: July 14, 2022Applicants: Brochier Technologies, Centre National de la Recherche Scientifique, Universite Claude Bernard Lyon 1Inventors: Eric PUZENAT, Cédric BROCHIER, Davide LORITO, Lina LAMAA, Laure PERUCHON
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Patent number: 11383053Abstract: The invention relates to a device for olfactory stimulation of a patient with a plurality of scents, said device comprising: —a source (2) of a carrier gas (G); —a plurality of scent odorization circuits, each odorization circuit (4) comprising: —a container (18) containing an odorous volatile substance (V), —a container inlet line (26), provided with a container inlet valve (28), connecting an inlet (30) of said container with said source of carrier gas, and —a container outlet line (36), provided with a container outlet valve (38), connecting an outlet (40) of said container with an exit line (12); —a control unit (8), configured to control said container inlet valve and container outlet valve according to a medical protocol.Type: GrantFiled: February 2, 2017Date of Patent: July 12, 2022Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1, UNIVERSITE JEAN MONNET SAINT ETIENNEInventors: Marc Thevenet, Patricia Viret
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Patent number: 11384081Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.Type: GrantFiled: September 20, 2017Date of Patent: July 12, 2022Assignees: CENTRE LEON BERARD, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Toufic Renno, Isabelle Coste-Invernizzi, Stéphane Giraud, Serge Lebecque
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Publication number: 20220186321Abstract: A method of prognosis of patient outcome and of the resistance to a chemotherapy treatment of an individual afflicted by a tumor. The method involves determining the amount of the product of each of at least 21 genes belonging to the group of 160 genes as set forth in SEQ ID NO: 1 to SEQ ID NO: 160.Type: ApplicationFiled: March 27, 2020Publication date: June 16, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE LÉON BERARD, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ CLAUDE BERNARD LYON 1Inventors: Véronique MAGUER-SATTA, Boris GUYOT, Flora CLÉMENT, Pierre SAINTIGNY, Jean-Philippe FOY, Emmanuel DELAY
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Publication number: 20220178949Abstract: The invention relates to a process in vitro for diagnosing a paraneoplastic neurological syndrome (PNS) associated with a tumor in an individual, comprising the detection of at least one antibody chosen among antibodies against TRIM9 and antibodies against TRIM67, in a biological fluid of said individual.Type: ApplicationFiled: May 2, 2019Publication date: June 9, 2022Applicants: HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Le Duy DO, Jérôme HONNORAT, Véronique ROGEMOND
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Patent number: 11351180Abstract: The present invention relates to a pharmaceutical or veterinary composition for the use thereof in preventing and/or treating infection by the influenza viruses. Said composition is characterized in that it contains, in an appropriate pharmaceutical carrier, at least one compound selected from among Etilefrine and Diltiazem.Type: GrantFiled: March 18, 2016Date of Patent: June 7, 2022Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), HOSPICES CIVILS DE LYON, UNIVERSITE LAVALInventors: Manuel Rosa-Calatrava, Olivier Terrier, Julien Textoris, Guy Boivin, Mario Pizzorno
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Publication number: 20220146402Abstract: A particle detector includes at least one resonant cavity partially formed at least by a first reflector, a second reflector disposed at a distance from the first reflector and a channel located between the first and second reflectors, the channel being intended to receive at least one fluid comprising particles and to receive at least one light radiation; and at least one detection system having at least one photodetector. The particle detector is configured so that a portion of the light radiation present in the channel escapes from the cavity throughout the second reflector and reaches the detection system, thereby enabling the at least one photodetector to detect leakage of the cavity. The second reflector is a photonic crystal membranes PCM based reflector.Type: ApplicationFiled: December 23, 2019Publication date: May 12, 2022Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CPE LYON, ECOLE CENTRALE DE LYON, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1Inventors: Gabriel JOBERT, Salim BOUTAMI, Maryse FOURNIER, Christian SEASSAL
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Patent number: 11313800Abstract: A method for the detection and quantification, in a complex aqueous fluid, of additives and water-soluble polymers used in the enhanced recovery of oil and shale gas.Type: GrantFiled: April 20, 2016Date of Patent: April 26, 2022Assignees: TOTAL SA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Mattéo Martini, Olivier Tillement, Arthur Marais, Christian Hurtevent, Stéphane Jouenne
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Publication number: 20220119893Abstract: The invention relates to an in vitro process for classifying a glioma, comprising the following steps: a. Measuring at least, from a glioma patient biological sample, the Alternative Lengthening of Telomeres (ALT) status of said glioma; b. Optionally, determining the isocitrate dehydrogenase genes mutation status (IDH status) of said glioma; c. Based on the data obtained in steps (a) and optionally (b) and, if available, on the histological grade of said glioma, classifying said glioma in one of the five following classes: oligodendroglioma-like, glioblastoma IDHwt-like, glioblastoma IDHmt-like, low-grade astrocytoma-like, and other gliomas.Type: ApplicationFiled: February 19, 2020Publication date: April 21, 2022Applicants: HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1Inventor: Delphine PONCET
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Patent number: 11287397Abstract: This gaseous elementary-particle detector is equipped with a readout plate comprising: conductive tiles (80) that are all identical to one another and all located at the same distance from an exterior face (39), these conductive tiles being distributed over the front face of a dielectric layer (72) and being mechanically separated from one another by a dielectric material (76), the smallest dimension of each tile being larger than 300 ?m, and electrical connections (88), which are located under the dielectric layer (72) and which electrically connect the conductive tiles in series so as to form conductive strips, these electrical connections being arranged so that each conductive tile belongs to a single conductive strip and each side of one tile is adjacent to the side of another tile belonging to another conductive strip.Type: GrantFiled: February 13, 2018Date of Patent: March 29, 2022Assignees: Université Claude Bernard Lyon 1, Centre National De La Recherche ScientifiqueInventor: Imad Laktineh