Abstract: The present invention relates to peptides biomarkers that are specifically recognized by autoantibodies present in the sera of patients with Rheumatoid Arthritis (RA). More specifically, the invention provides epitopes of PAD4, of BRAF, and of calpastatin as well as methods and kits for using these sequences for the diagnosis of RA, in particular for the diagnosis of RA in CCP-negative subjects.
Type:
Application
Filed:
March 29, 2010
Publication date:
April 5, 2012
Applicant:
UNIVERSITE DE LA MEDITERRANEE - AIX-MARSEILLE 11