Abstract: A method for controlling an insulin injection device and a system for delivering insulin in a patient in need thereof. The method includes the steps of defining a time interval; receiving the level of blood glucose; computing an insulin dose to be injected in the next time interval, and transmitting the computed insulin dose to be injected to the insulin injection device.

Abstract: A microstructured substrate includes a plurality of at least one elementary microstructure. An electrical storage device, and more particularly an all-solid-state battery, can include the microstructured substrate.

Abstract: Described herein are anti-CD277 antibodies which: activates or inhibit the cytolytic function of V?9/V?2 T cells, and/or costimulates T cells together with CD3-TCR, and/or costimulates T cells in addition to CD28-B7 costimulation, and/or increases the activity and/or survival of monocytes and dendritic cells. The use of said antibodies in therapy is also described.

Abstract: The invention relates to a genetically modified infectious measles virus derived from a live-attenuated measles virus strain, in which the gene encoding the viral accessory C protein has been knocked out (MV-deltaC). It concerns in particular the use of said genetically modified infectious MV-deltaC in the treatment of malignant tumor or cancer conditions, and for the preparation of agents or compositions for such treatment.

Abstract: Device for measuring the endogenous deformations of a structure of materials, during the transition of said structure from a liquid phase to a solid phase, comprising: a uniaxial test body suitable for being embedded in the structure; a deformation measurement fiber attached to the interior of the test body; a system connected to the measurement fiber and suitable for detecting signals representative of the deformations of the measurement fiber and for determining the endogenous deformations from these signals and from known mechanical properties of the materials of the test body, the test body having a rigidity comprised between 2 and 5 gigapascals.

Abstract: The present invention relates to composite material comprising a matrix and a metallic layer located at at least one surface of said composite material, said matrix comprising at least one polymer and a first population of particles of at least one electronically conducting metal, said layer comprising a second population of particles of at least one electronically conducting metal, a method for preparing such composite material and applications thereof.

Abstract: The present invention relates to multimeric mannosides, a process for preparing the same and their uses in medicine for treating Escherichia coli infections.

Abstract: Method of assembling a first thin copper part and a second thin aluminum part, each to be welded using heterogeneous welding, includes placing the ends of the parts so that they face one another and pressing the ends against one another so as to constitute a welding zone extending therebetween; and applying an aluminum alloy by way of filler metal to the welding zone using a low energy welding method in which the electric arc and the meltable filler wire are wider than the combined thickness of the parts, the parts being held so as to maintain the welding zone at the top using a fixing element including at least two rigid blocks of a conductive material whose thickness is between 1 and 2 mm, whose length is greater than that of the parts and whose width is sufficient to hold the parts, and a pressure fixing system.

Abstract: The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory diseases. In particular, the present invention relates to an IL-15 mutant polypeptide having the amino acid sequence as set forth in SEQ ID NO:1 wherein the leucine residue at position 45 is substituted by an aspartic acid residue, the asparagines residue at position 65 is substituted by a lysine residue and the leucine residue at position 69 is substituted by an arginine residue.

Abstract: The present invention concerns novel fused pyrimidinone and triazinone derivatives containing bridged nitrogen, their process of preparation and their use as antifungal or antiparasitic agents.

Abstract: The invention relates to a Rac1 inhibitor for use as bronchodilator in a patient in need thereof. The invention provides a Rac1 inhibitor for use in a method for inducing bronchodilation in a patient in need thereof. The invention also relates to a Rac1 inhibitor for use in a method for reducing AHR in a patient in need thereof.

Abstract: The invention relates to a method for controlling an automated orbital sander, in which method an electrically powered orbital sander is moved around automatically, at constant pressure, over the surface of an object, along at least one predefined sanding path so as to perform sanding, characterized in that the instantaneous power consumed by the sander along the sanding path is measured and in that the measurement thus taken is processed in order to deduce therefrom information regarding the level of abrasion along said path and/or to detect any sanding incident that has occurred along the latter.

Abstract: The present invention relates to the field of lithium-sulphur batteries having high energy and power densities. In particular the present invention relates to a lithium-sulphur battery comprising a porous separator made of biaxially oriented polypropylene and to its process of manufacture.

Abstract: The invention relates to an peptide derived from a polymorphic region of donor MHC class II molecules which induces tolerance and thus prevents transplant rejection in a patient in need thereof. The invention relates to an isolated peptide of 15 or 16 amino acids long that comprises or consists of the amino acid sequence: REEYARFDSDVGEYR (SEQ ID NO: 1) or a function-conservative variant for use as drug. The invention relates to an in vitro method for determining whether a transplanted patient is tolerant, comprising a step of determining the presence of CD8+CD45RClow Tregs in a biological sample obtained from said transplanted patient, wherein the presence of CD8+CD45RClow Tregs is indicative of tolerance.

Abstract: The present invention relates to a compound with formula (I) or a salt and/or a pharmaceutically acceptable solvate thereof, the method for preparing same as well as the uses thereof, in particular the therapeutic use thereof, mainly in the treatment of diseases associated with a hyperactivity of the endocannabinoid system.

Abstract: The invention relates to a method of determining characteristics of orifices (O1, . . . , O9) to be made through a plate (2) positioned in a circuit (10) across the fluid passage. Said method comprises defining fluid data, the number of orifices, and for each orifice a control segment or area. The fluid flow rate through each orifice of the perforated plate is calculated, and for each orifice, the flow rate density is calculated by dividing said fluid flow rate by the associated control segment length or control area. The optimized or non-optimized nature of the orifice characteristic is determined by comparing said flow rate density with the mean flow rate density. If the difference in absolute value lies within a predetermined range of values, then the orifice characteristics are considered as being optimized. Otherwise at least one characteristic of at least some of the orifices is modified.

Abstract: The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.

Abstract: The invention concerns a device for locally measuring strains within a measurement volume that comprises a test body formed from a homogeneous material of known mechanical properties and ellipsoidal in shape intended to be included in the measurement volume, at least one measurement optical fiber for measuring deformation embedded within said test body and means for linking the at least one measurement optical fiber to a system designed to stimulate the at least one measurement optical fiber, detect signals coming from the fibers and, by means of an electronic system capable of carrying out calculations, determine strains from at least one of the detected signals and known mechanical properties.

Abstract: An antibody recognizing the O-acetylated-GD2 ganglioside for the treatment of Cancer Stem Cells (CSC) cancer, a pharmaceutical composition including the antibody for treating a CSC cancer and a method for treating a CSC cancer in a patient in need thereof, the method including administering the antibody to the patient. A method for diagnosing a CSC, the use of the O-acetylated-GD2 ganglioside as a biomarker of CSC cancer, and a method for predicting the response of a subject affected with CSC cancer to a treatment with the antibody or the composition are also described.

Abstract: A composition for treating Neurodegenerative Diseases with Parkinsonian Syndromes in a subject in need thereof, wherein the composition includes an effective amount of a modulator of a chloride transporter.