Patents Assigned to UNIVERSITE LILLE 2 DROIT ET SANTE
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Publication number: 20200038489Abstract: The present invention relates to a von Willebrand factor composition for the prevention and/or the treatment of haemorrhage and/or bleeding in patients with mechanical circulatory support.Type: ApplicationFiled: October 10, 2019Publication date: February 6, 2020Applicants: Laboratoire Francais du Fractionnement et des Biotechnologies, Ctre Hospitalier Universitaire de Lille, Universite Lille 2 Droit et SanteInventors: Sophie SUSEN, Andre VINCENTELLI, Eric VAN BELLE, Antoine RAUCH, Flavien VINCENT
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Patent number: 10478475Abstract: The present invention relates to a von Willebrand factor composition for the prevention and/or the treatment of haemorrhage and/or bleeding in patients with mechanical circulatory support.Type: GrantFiled: April 6, 2016Date of Patent: November 19, 2019Assignees: LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES, CTRE HOSPITALIER UNIVERSITAIRE DE LILLE, UNIVERSITE LILLE 2 DROIT ET SANTEInventors: Sophie Susen, Andre Vincentelli, Eric Van Belle, Antoine Rauch, Flavien Vincent
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Publication number: 20180110838Abstract: The present invention relates to a von Willebrand factor composition for the prevention and/or the treatment of haemorrhage and/or bleeding in patients with mechanical circulatory support.Type: ApplicationFiled: April 6, 2016Publication date: April 26, 2018Applicants: Laboratoire Francais du Fractionnement des Biotechnologies, CTRE Hospitalier Universitaire de Lille, Universite Lille 2 Droit et SanteInventors: Sophie SUSEN, Andre VINCENTELLI, Eric VAN BELLE, Antoine RAUCH, Flavien VINCENT
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Patent number: 9808169Abstract: The invention relates to a system for electroencephalographic detection of an improper adjustment of a ventilator used on a mammal. The system includes an electroencephalograph, capable of measuring, as a function of time, an electroencephalographic signal representative of a breathing process; and an input for receiving a respiratory initiation signal, different from the electroencephalographic signal, capable of indicating a respiratory initiation time. The detection system further includes means for specifying a beta frequency band comprised between 15 and 30 Hz and with a width comprising between 5 and 10 Hz; means for processing the measured electroencephalographic signal, configured for processing the measured electroencephalographic signal as it is being acquired, in the sole specified beta frequency band; and means for identifying, for each breathing cycle, an improper adjustment of the ventilator from the electroencephalographic signals processed in the sole beta frequency band.Type: GrantFiled: July 6, 2011Date of Patent: November 7, 2017Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, UNIVERSITE LILLE 2 DROIT ET SANTE, CENTRE HOSPITALIER UNIVERSITAIRE DE LILLEInventors: Thomas Similowski, Mathieu Raux, Louise Tyvaert
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Patent number: 9796758Abstract: A method for producing a polypeptide, includes at least one native ligation step using a peptide functionalized with a selenium group. The selenium peptides and compounds are also described.Type: GrantFiled: March 18, 2013Date of Patent: October 24, 2017Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT PASTEUR DE LILLE, UNIVERSITE LILLE 2 DROIT ET SANTEInventors: Oleg Melnyk, Laurent Raibaut, Nathalie Ollivier
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Patent number: 9778259Abstract: The present invention concerns an in vitro method for diagnosing invasive candidiasis (IC) in a subject which comprises detecting the presence of a Candida glycan and detecting the presence of antibody directed against a protein selected from the group consisting of fructose bisphosphate aldolase (Fba1), enolase 1 (Eno1), heat shock protein 90 (Hsp90), hyphal wall protein (Hwp1), and mannoprotein 65 (Mp65) in a blood, plasma or serum sample of the subject. The invention also relates to a method of determining a suitable treatment regimen for a patient and to a kit for implanting the methods described herein.Type: GrantFiled: March 18, 2013Date of Patent: October 3, 2017Assignees: Bio-Rad Innovations, Centre Hospitalier Universitaire De Lille, Universite Lille 2 Droit et SanteInventors: Sebastien Damiens, Chantal Fradin, Daniel Poulain, Boualem Sendid, Marc Charles Victor Tabouret
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Publication number: 20150045506Abstract: A method for producing a polypeptide, includes at least one native ligation step using a peptide functionalized with a selenium group. The selenium peptides and compounds are also described.Type: ApplicationFiled: March 18, 2013Publication date: February 12, 2015Applicants: UNIVERSITE LILLE 2 DROIT ET SANTE, INSTITUT PASTEUR DE LILLEInventors: Oleg Melnyk, Laurent Raibaut, Nathalie Ollivier
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Patent number: 8680095Abstract: The present invention relates to compounds having the following Formula (I) for use in the prevention and/or the treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs.Type: GrantFiled: December 16, 2010Date of Patent: March 25, 2014Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Lille 2 Droit et Sante, Centre National de la Recherche Scientifique (C.N.R.S.), Universite Lille 1—Sciences et TechnologiesInventors: Andre Delacourte, Patricia Melnyk, Stephane Burlet, Nicolas Lefur
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Publication number: 20130204150Abstract: The invention relates to a system for electroencephalographic detection of an improper adjustment of a ventilator used on a mammal. The system includes an electroencephalograph, capable of measuring, as a function of time, an electroencephalographic signal representative of a breathing process; and an input for receiving a respiratory initiation signal, different from the electroencephalographic signal, capable of indicating a respiratory initiation time. The detection system further includes means for specifying a beta frequency band comprised between 15 and 30 Hz and with a width comprising between 5 and 10 Hz; means for processing the measured electroencephalographic signal, configured for processing the measured electroencephalographic signal as it is being acquired, in the sole specified beta frequency band; and means for identifying, for each breathing cycle, an improper adjustment of the ventilator from the electroencephalographic signals processed in the sole beta frequency band.Type: ApplicationFiled: July 6, 2011Publication date: August 8, 2013Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE HOSPITALIER UNIVERSITAIRE DE LILLE, UNIVERSITE LILLE 2 DROIT ET SANTE, ASSISTANCE PUBLIQUE-HOPITAUX DE PARISInventors: Thomas Similowski, Mathieu Raux, Louise Tyvaert
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Publication number: 20120238461Abstract: The present invention relates to an in vitro method for determining that an individual is at risk of developing Alzheimer's disease, which comprises: —determining whether the individual harbours at least one variant allele of a susceptibility gene selected from the apolipoprotein J gene (APOJ) and the complement component receptor 1 gene (CR 1); —deducing that if the individual harbours at least one variant allele of the APOJ and/or CR1 gene, then the individual is at risk of developing Alzheimer's disease.Type: ApplicationFiled: August 27, 2010Publication date: September 20, 2012Applicants: INSTITUT PASTEUR DE LILLE, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE LILLE 2 DROIT ET SANTEInventors: Philippe Amouyel, Mark Lathrop, Jean-Charles Lambert
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Publication number: 20120149735Abstract: The present invention relates to 1,4-dihydropyridine derivatives of the formula (I) and their uses in the treatment and/or prevention of diseases and disorders directly or indirectly associated with the modification (increase or decrease) of the activity of the cannabinoid receptor 2 (CB2).Type: ApplicationFiled: May 19, 2010Publication date: June 14, 2012Applicants: CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE, UNIVERSITE LILLE 2 DROIT ET SANTEInventors: Regis Millet, Jamal El Bakali, Philippe Chavatte, Nicolas Renault, Didier Lambert, Giulo Muccioli, Mathilde Body-Malapel, Pierre Desreumaux