Patents Assigned to Universite Pierre et Marie Curie
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Patent number: 10711232Abstract: The invention relates to a bioreactor comprising a tank containing a culture medium in which a cell culture composed of algae cells is dispersed. The cell culture of algae has a concentration greater than 0.1 g/L in the culture medium, and each algal cell has a minimum absorption in a specific range of wavelengths of light. The bioreactor comprises a light source that is capable of emitting incident light in the direction of the tank, 60% of the photons of the incident light having a wavelength which is included in said specific range of wavelengths of light. The invention also relates to the use of the bioreactor for the production of biomass.Type: GrantFiled: March 18, 2016Date of Patent: July 14, 2020Assignees: Inria Institut National De Recherche En Informatique Et En Automatique, Centre National De La Recherche Scientifique (C.N.R.S.), Universite Pierre Et Marie Curie (Paris 6)Inventors: Francis Mairet, Olivier Bernard, Antoine Sciandra, Eric Pruvost, Charlotte Combe
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Patent number: 10680241Abstract: The present application describes a process for the preparation of titanium-based compounds having an anatase type structure with cationic vacancies arising from a partial substitution of oxygen atoms by fluorine atoms and hydroxyl groups. Electrochemically active materials comprising the titanium-based compounds for use in lithium-ion battery electrodes are also described.Type: GrantFiled: November 20, 2015Date of Patent: June 9, 2020Assignees: HYDRO-QUEBEC, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Damien Dambournet, Wei Li, Henri Groult, Sandrine Leclerc, Christian Julien, Karim Zaghib
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Patent number: 10668129Abstract: The present invention relates to the synergistic combination of the short and long Rod-Derived Cone Viability Factors and to methods for treating retinal degenerative diseases.Type: GrantFiled: May 20, 2016Date of Patent: June 2, 2020Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Thierry Leveillard, John Flannery, Xin Mei, Leah Byrne, José-Alain Sahel, Emmanuelle Clerin-Lachapelle, Junwei Sun, Jean Bennett, Jeannette Bennicelli
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Patent number: 10661274Abstract: Disclosed is a fluidic device including at least: a) a solid matrix; b) a textile component, embedded in the matrix and mechanically cohesive with the matrix; c) at least one channel embedded in the matrix and entangled with the textile component, the channel being at least partly open. A method for making a fluidic device includes providing a textile component including support fibers and at least a movable fiber entangled with the textile, embedding at least part of the textile and part of the movable fiber, in a matrix precursor material, applying a treatment in order to obtain a solid matrix.Type: GrantFiled: July 22, 2016Date of Patent: May 26, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE PIERRE ET MARIE CURIEInventors: Jean-Louis Viovy, Bastien Venzac, Laurent Malaquin, Stephanie Descroix
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Patent number: 10653387Abstract: Method for functional imaging of the brain, comprising the following steps: (a) a brain is imaged by ultrasound imaging in order to obtain a vascular image to be studied (IVO), (b) the vascular image to be studied (IVO) is compared automatically, by shape recognition, with a cerebral vascular atlas (AV), and the vascular image to be studied (IVO) is thus located in the cerebral vascular atlas (AV), (c) a cerebral functional atlas (AF) corresponding to said cerebral vascular atlas (AV) and comprising cerebral functional zones (1c) located in this cerebral vascular atlas (AV) is used in such a way as to identify cerebral functional zones (1e) on the vascular image to be studied (IVO).Type: GrantFiled: June 29, 2015Date of Patent: May 19, 2020Assignees: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ÉCOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITÉ PARIS DIDEROT—PARIS 7Inventors: Mickaél Tanter, Jean-luc Gennisson, Thomas Deffieux, Mathieu Pernot
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Patent number: 10639472Abstract: The invention relates to a process for manufacturing at least one implant for focal electrical stimulation of a nervous structure, said implant being of the type including in a supporting structure a network of cavities at the bottom of which are placed microelectrodes, the cavities being bounded by walls erected and located around the microelectrodes, the supporting structure being produced beforehand by implementing the following steps: deposition and etching, in a planar manner, on an insulating substrate, of electrical contacts, of electrical tracks and of microelectrodes, first tracks electrically connecting the microelectrodes and the electrical contacts, second electrical tracks being electrically connected to a ground.Type: GrantFiled: November 19, 2015Date of Patent: May 5, 2020Assignees: Chambre de Commerce et D'Industrie de Region Paris Ile de France (ESIEE Paris), Universite Pierre Et Marie Curie (Paris 6), Centre National de la Recherche Scientifique (CNRS), Institut National de la Sante et de la Recherche Medicale (INSERM)Inventors: Lionel Rousseau, Gaëlle Lissorgues, Myline Cottance, Serge Picaud, Julie Degardin
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Patent number: 10590420Abstract: The invention relates to a method for the treatment of amyotrophic lateral sclerosis (ALS). Specifically, the invention implements the use of an antisense sequence adapted to affect alternative splicing in a human SOD1 pre-mRNA, thereby leading to the destruction of the skipped m RNA by the cell machinery.Type: GrantFiled: July 31, 2015Date of Patent: March 17, 2020Assignees: ASSOCIATION INSTITUT DE MYOLOGIE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)Inventors: Martine Barkats, Maria-Grazia Biferi, Thomas Voit
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Patent number: 10578619Abstract: The present invention relates to methods and kits for identifying effector regulatory T cells. In particular the present invention relates to use of CD15s as a biomarker for eTreg cells. The present invention also relates to a method for identifying effector Treg cells (eTreg) in a fluid sample comprising the steps of i) detecting the cell surface expression of CD4, CD25, CD127 and CD15s markers on the cell population contained in the fluid sample and ii) concluding that the cells expressing CD4, CD25, CD127 at low levels and CD15s are the effector Treg cells. The present invention also relates to a method for identifying effector Treg cells (eTreg) in a tissue sample comprising the steps of i) detecting the cell expression of CD4, CD25, Foxp3 and CD15s markers and ii) concluding that the cells expressing CD4, CD25, Foxp3 and CD15s are the effector Treg cells.Type: GrantFiled: July 30, 2014Date of Patent: March 3, 2020Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)Inventors: Guy Gorochov, Makoto Miyara
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Publication number: 20200049127Abstract: The invention relates to a method for designing a flexible blade or an articulated rigid blade with one or more torsion springs, for a wind turbine or a water turbine, the flexible blade being designed to passively control the pitch angle of the wind turbine or of the water turbine during operation, the method comprising the following steps: a) receiving the known geometric profile; b) determining a change in the optimal pitch angle, 0o opt rigid, as a function of the specific speed ?; c) determining the local behaviour of the flexible blade or of the articulated blade and local ratios relating to the aerodynamic loading and to the centrifugal force being exerted on the blade; d) determining local values of the bending modulus B of the flexible blade/the stiffness of the torsion spring and of the mass density p of the blade; and e) providing information relating to the selection of the material.Type: ApplicationFiled: February 14, 2018Publication date: February 13, 2020Applicants: Universite Paris Diderot Paris 7, Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris, Centre National de la Recherche Scientifique (CNRS), Universite Pierre Et Marie Curie (Paris 6)Inventors: Vincent Cognet, Sylvain Courrech Du Pont, Benjamin Thiria
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Patent number: 10530971Abstract: A pixel cell circuit comprises an electrode, one or more main photosensitive elements electrically coupled to the electrode for outputting a stimulation signal to the electrode responsive to light illumination, and a shunt arrangement comprising a shunt switch electrically coupled in parallel across the one or more photosensitive elements, and a control arrangement operatively coupled to the shunt switch and configured for placing the shunt switch in an open state responsive to incident light received at the pixel cell and placing the shunt switch in a closed state if no incident light is received at the pixel cell.Type: GrantFiled: April 6, 2016Date of Patent: January 7, 2020Assignees: PIXIUM VISION, UNIVERSITE PIERRE ET MARIE CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Daniel Matolin, Christoph Posch, Benjamin Ryad Benosman
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Patent number: 10519039Abstract: The present invention relates to a process for the preparation of a boron phosphide, more specifically BP and/or B12P2, comprising the mechanochemical reaction of boron phosphate (BPO4) with at least one alkaline earth metal (EA). In particular, the process of the invention allows for the selective preparation of either BP or B12P2 with more than 95% purity, through the reduction of boron phosphate (BPO4) with at least one alkaline earth metal (EA) according to reaction (1) for BP and according to reaction (2) for B12P2: BPO4+4 EA?BP+4 EA(O) (1) 2BPO4+5 (EA)B2+3 EA?B12P2+8 EA(O) (2). The present invention further relates to boron phosphide powders, in particular BP or B12P2 powders, of nanometric or micrometric size.Type: GrantFiled: April 8, 2016Date of Patent: December 31, 2019Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIV PARIS XII-NORD VILLETANEUSEInventors: Yann Le Godec, Vladimir A. Mukhanov, Vladimir L. Solozhenko, Petr S. Sokolov, Dominique Vrel
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Publication number: 20190381115Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.Type: ApplicationFiled: November 13, 2015Publication date: December 19, 2019Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP), ECOLE D'INGENIEURS DE PURPANInventors: Philippe LANGELLA, Sylvie MIQUEL, Rebeca MARTIN ROSIQUE, Luis BERMUDEZ HUMARAN, Muriel THOMAS, Harry SOKOL, Frédéric CARVALHO, Vassilia THEODOROU
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Patent number: 10507234Abstract: The present invention relates to methods and pharmaceutical compositions of inducing immune tolerance by mucosal vaccination with Fc-coupled antigens. In particular, the present invention relates to a method for inducing tolerance to one antigen of interest in a subject in need thereof, comprising the mucosal administration to the subject of a therapeutically effective amount of a recombinant chimeric construct comprising a FcRn targeting moiety and an antigen-containing moiety.Type: GrantFiled: July 13, 2016Date of Patent: December 17, 2019Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS DESCARTES, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS DIDEROT—PARIS 7Inventors: Roberto Mallone, Slobodan Culina, Nimesh Gupta, Sebastien Lacroix-Desmazes
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Patent number: 10494410Abstract: The invention concerns peptides useful as MAP kinase/ERK pathway-specific inhibitors relative to a given substrate in a given subcellular compartment.Type: GrantFiled: February 22, 2016Date of Patent: December 3, 2019Assignees: UNIVERSITE PIERRE ET MARIE CURIE, Centre National de la Recherche Scientifique—CNRS—Inventors: Jocelyne Caboche, Peter Vanhoutte
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Publication number: 20190353590Abstract: The invention relates to a portable device (1) for estimating at least one parameter characteristic of a polymer material, characterized in that the device comprises at least one infrared source (101), each infrared source (101) being capable of emitting towards the polymer material a spectral line, representing maximum emission energy, selected in one of the wavelengths 10 ?m, 9.5 ?m, 7.2 ?m, 6 ?m, 3.5 ?m, 2.7 ?m or in one of the wave numbers 1000 cm?1, 1050 cm?1, 1350 cm?1, 1700 cm?1, 2900 cm?1, 3700 cm?1, at least one infrared detector (102), capable of receiving infrared radiation (112), which is reflected by the polymer material (M) in response to the spectral line, a unit for determining the parameter characteristic of the polymer material (M) as a function of the energy present in said spectral line in the infrared radiation (112), having been reflected by the polymer material (M) and having been received by the infrared detector (102).Type: ApplicationFiled: November 17, 2017Publication date: November 21, 2019Applicants: Electricite de France, Universite Pierre Et Marie Curie (Paris 6)Inventors: Alejandro Ribes Cortes, Mohamed Ben Chouikha
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Publication number: 20190338423Abstract: A sol-gel method for producing an anti-corrosion coating consisting of at least one layer of an oxide on a metal substrate. A non-aqueous solution of a precursor of the oxide is prepared and deposited on one surface at least of the metal substrate in order to cover said surface at least partially with a film comprising the precursor of the oxide. Hydrolysis-condensation of the precursor of the oxide is carried out by exposing the film to a humid atmosphere in order to form an oxide network in the film. Then, a treatment for stabilizing the film on the surface of the substrate is carried out, followed by a heat treatment of the surface of the metal substrate in order to crystallize the network of oxide and form the anti-corrosion coating.Type: ApplicationFiled: December 20, 2017Publication date: November 7, 2019Applicants: ELECTRICITE DE FRANCE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE- CNRS-, COLLEGE DE FRANCEInventors: Adele Astorg, Xavier Crozes, Lionel Nicole, Clement Sanchez
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Patent number: 10440296Abstract: Disclosed is a method for processing an asynchronous signal produced by a light sensor, the sensor having a pixel matrix disposed opposite a scene, the method including: receiving from the light sensor the asynchronous signal including, for each pixel of the matrix, successive events from the pixel; analysing the asynchronous signal using activity profiles as events are received in the asynchronous signal. The activity profile includes at least, for each pixel of the sensor, an activity value that decreases as a function of the time that has passed since the most recent event among the successive events from the pixel.Type: GrantFiled: March 15, 2016Date of Patent: October 8, 2019Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Ieng Sio-Hoi, Benosman Ryad, Shi Bertram
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Patent number: 10371774Abstract: A method for carrying out two-field nuclear magnetic resonance (=2FNMR) measurements involves preparing a sample (9a) in a first working volume (5) of a highly homogeneous magnetic field with a first field strength; transferring the sample (9a) to a second working volume (7) with a magnetic field having lower homogeneity and having a second field strength, wherein the first field strength is at least 2 Tesla larger than the second field strength; manipulating the sample (9a) at the second working volume (7) by applying a sequence of radio-frequency (=RF) and/or field gradient pulses; transferring the sample (9a) back to the first working volume (5); and detecting an NMR signal of the sample (9a) in the first working volume (5). The method allows for NMR experiments with which more and/or improved quality information about an investigated sample can be obtained.Type: GrantFiled: April 12, 2016Date of Patent: August 6, 2019Assignees: Bruker S.A.S, Ecole normale supérieur, Centre National de la Recherche Scientifique, Université Pierre et Marie Curie (Paris 6)Inventors: Samuel Cousin, Cyril Charlier, Fabien Ferrage, Jean-Max Tyburn, Thorsten Marquardsen
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Patent number: 10365246Abstract: Device for the representation, in a frequency-wave number reference frame f-k, of the propagation of an ultrasound wave in a dihedral guide (1), which comprises ultrasound emitters (2) referenced by “Ej” with j an integer varying between 1 and N, N a strictly positive integer and ultrasound receivers (3) referenced by “Ri” with i an integer varying between 1 and M, M a strictly positive integer, the receivers being disposed spatially over a first segment of a straight line according to a regular pitch “A”, which comprises means for processing the signal received by the receivers, originating from the emitters, and in which the processing means comprise means for calculating a modified discrete spatial Fourier transform, for a spatial integration variable “x”, centered in the middle of said first segment and running through the receivers in the direction of increasing x, and for a wave vector k(x) equal to a product k.Type: GrantFiled: July 4, 2014Date of Patent: July 30, 2019Assignees: Azalée, Centre National de la Recherche Scientifique, Université Pierre et Marie Curie - Paris 6Inventors: Ludovic Moreau, Jean-Gabriel Minonzio, Maryline Talmant, Pascal Laugier
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Publication number: 20190228919Abstract: The invention relates to a supercapacitor comprising: an electrolyte having a first end and a second end opposite the first end, a first electrode in contact with the first end of the electrolyte, and a second electrode in contact with the second end of the electrolyte. In particular, the electrolyte is made of a solid material that is ion-conductive and electronically insulating.Type: ApplicationFiled: September 29, 2017Publication date: July 25, 2019Applicants: PARIS SCIENCES ET LETTRES - QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIME INDUSTRIELLES DE LA VILLE DE PARISInventors: Brigitte Leridon, Stéphane Hole, Rémi Federicci