Abstract: The present invention relates to nucleic acid regulatory elements that are able to enhance muscle-specific expression of genes, in particular expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly muscle-directed gene therapy, and for vaccination purposes.

Abstract: The present invention relates to the field of recombinant protein production in a host cell. More specifically the invention relates to the field of oral protein delivery. Specifically, the invention provides oral pharmaceutical formulations comprising the culture medium of a recombinant host secreting a recombinant protein. The resulting oral pharmaceutical formulations are useful for the treatment of gastro-intestinal and/or buccal disorders. Additionally, the oral pharmaceutical formulations are useful for prophylactic and vaccine purposes.

Abstract: The invention relates to a method to prepare a precursor for a polymer or to prepare a polymer, the polymer comprising at least one unit of formula (I) or at least one unit of formula (II) having a tertiary amine and a pendant carboxyl group Furthermore the invention relates to a precursor or polymer comprising at least one unit of formula (I) and/or at least one unit of formula (II) and to the use of such precursor or such polymer in extrusion, injection moulding, compression moulding, transfer moulding, foam moulding, thermoforming, rotation moulding or 3D printing

Abstract: The present invention relates to the field of plant genetic engineering, particularly the modulation of gene expression in plant cells for improved regeneration competence. The invention discloses means and methods wherein the Ethylene Response Factor (ERF) and Phytochrome A Signal Transduction 1 (PAT1) transcription factor complex activity in plant cells grants increased regeneration.

Abstract: The present invention provides a post-fabrication modification approach for the fabrication of colored and chromic materials and sensors using plasma surface modification to covalently bind the coloring agent to the substrate, thus avoiding leaching of the dye. Advantageously, in said methods, said coloring agent is a dye or pigment linked to a radical sensitive functional group, such as an alkenyl or alkynyl functional group, and is applied to the substrate prior to the gas plasma treatment. The methods envisaged herein are generic in nature, which allow the covalent immobilization of various dyes on different materials. The covalently coated materials after plasma surface modification, particularly the covalently coated chromic materials and sensors, can be used in many different applications, such as protective textile and wound dressing applications.

Abstract: The invention relates to a method to prepare pockets comprising encapsulated material. The pockets are formed by first forming one or more bases B of barrier material on a substrate, by subsequently applying core material on at least part of the bases B and by forming a lid L on bases B provided with core material. The core material comprises at least one photoemissive particle or photoemissive compound such as quantum dots. The invention also relates to a pocket or a plurality of pockets comprising encapsulated material obtained by such method, to a device comprising at least one pocket of encapsulating material and to a process to transfer such a pocket of encapsulated material from one substrate to another substrate.

Abstract: The present invention generally relates to the field of ionizable (also termed cationic) lipids, and in particular provides a novel type of such lipids as represented by formula (I). The present invention further provides methods for making such lipids as well as uses thereof, in particular in the preparation of nanoparticle compositions, more in particular nanoparticle compositions comprising nucleic acids. It further provides vaccine formulations comprising nanoparticle compositions based on the ionizable lipids disclosed herein.

Abstract: Provided is an elbow joint prosthetic implant (100) comprising: a humeral component (50) comprising a humeral stem portion (60) configured for placement within the humeral intramedullary canal of a subject, an ulnar component (110) comprising an ulnar stem portion (120) configured for placement within the ulnar intramedullary canal of the subject, wherein the humeral component (50) and ulnar component (110) are connected by an implant elbow joint (130), wherein the ulnar component (110) further comprises an angulation joint (140) that is separate from the implant elbow joint (130), wherein the angulation joint (140) and has at least one degree of freedom of rotational movement configured to adjust and fix a varus-valgus direction of the ulnar stem portion (120).

Abstract: The present invention provides nucleotide sequences encoding polypeptides comprising immunoglobulin variable domains with engineered glycosylation acceptor sites. Specifically, the invention provides immunoglobulin variable domain proteins modified with selected glycans and specific glycan-conjugates thereof. Also provided herein are methods for the production of glycosylated immunoglobulin variable domains and glycan-conjugates thereof.

Abstract: The disclosure relates to a computer-implemented method and control system for controlling provisioning of a service in a network. A network function specification data structure of a network function of the service is obtained, wherein the network function specification data structure is associated with at least a first network function implementation, e.g. a physical network function implementation, and a second network function implementation, e.g. a virtual network function implementation, for performing the network function of the service. Network service provisioning is controlled comprising selecting the first network function implementation or the second network function implementation of the network function in the network function specification data structure.

Abstract: A method for gait retraining of a runner includes: measuring acceleration data of at least one lower leg of the runner; diagnosing the acceleration data thereby determining a measure of the impact intensity of at least one external tibial shock; and providing real-time feedback to the runner by converting the measure of the impact intensity into distortion of music to a level which is perceived by the runner as a measure for the impact intensity. The conversion is done based on a predefined relationship between perceived distortion levels and imposed distortion levels, and the runner can reduce the distortion of the music by adjusting his or her gait.

Abstract: An extruder for extrusion of material, the extruder comprising a screw (110), a barrel (120), a controller, and a force sensor wherein at least a section (110b) of the screw (110) is conical and wherein at last a section (120b) of the barrel (120) is conical wherein the extruder (100) is adapted for displacing the screw (110) in an axial direction of the screw (110), such that by an axial displacement of the screw with regard to the barrel the size of a leakage gap (180) between the screw (110) and the barrel (120) is modified, wherein the extruder is adapted for actively obtaining operational characteristics and wherein the controller (160) is adapted for controlling the axial displacement of the screw (110) as a function of the operational characteristics of which at least one is an upward force of the material or an upward force on the screw.

Abstract: Polyoxazoline polymers, polymer combinations, and compositions comprising those polymers or combinations of polymers are disclosed. The invention further relates to the use of said polyoxazoline polymers, said combinations and compositions comprising such polymers and combinations for the sustained release of one or more active ingredients, in particular one or more active pharmaceutical ingredients. It further relates to the use of polyoxazoline polymers or polymer combinations as drug carrier.

Abstract: The present invention relates to an implantable device (10) for repairing at least one tendon or ligament, advantageously comprising a hollow braid (20) configured to receive in its interior volume (30) at least one portion of a tendon or ligament, and comprising over its length a central repair part (40) arranged between first and second lateral parts (50, 60). The braiding angle (?) in at least one region (42) of the central part (40) at rest is smaller than the braiding angle (?1) in at least one region (52) of the first lateral part (50) and/or than the braiding angle (?2) in at least one region (62) of the second lateral part (60) at rest.

Abstract: The present invention relates to a method for covalently binding a first agent and a second agent, the first agent comprising a first recognition element, wherein the first recognition element comprises an 1,4-dioxo moiety having a structure of Formula IA, IB or IC, wherein R12 is C1-30alkyl, C2-30alkenyl, C6-15aryl, or C5-15heteroaryl, wherein the C1-30alkyl, C2-30alkenyl, C6-15aryl, or C5-15heteroaryl group are optionally substituted with an C1-6alkyl, C3-6cycloalkyl, halogen, amine, hydroxyl, sulfhydryl, carboxyl, or C1-6alkoxy; and R13, if present, is hydrogen, C1-30alkyl or C2-30alkenyl; the second agent comprising a second recognition element, wherein the second recognition element comprises a nucleophilic moiety selected from a hydrazine moiety, an aminooxy moiety, an aminosulfanyl moiety or a hydroxylamine moiety; wherein: (A) the first recognition element and the second recognition element are capable of non-covalently binding to each other such that the 1,4-dioxo moiety and the nucleophilic moiety a

Abstract: A device for holding and monitoring a predetermined dose of a product during a freezing, drying and/or lyophilization process, includes a mold having a receptacle part for containing the predetermined dose of the product in direct contact with the receptacle part, a sensor, contacting the mold or integrated in the mold, for measuring a physical characteristic and/or quantity, and a transmitter for transmitting the measured characteristic and/or quantity in the form of a sensor signal to a control unit for controlling a heating and/or cooling element, integrated in the device, for heating and/or cooling a predetermined dose of product during a freezing, drying and/or lyophilization process, in the lyophilization process. The device relates in further aspects to a system and a method.

Abstract: Provided herein are lipidated imidazoquinoline compounds and compositions comprising such compounds. The lipidated imidazoquinoline compounds may be used as an adjuvant to enhance to immune response elicited by an antigen of interest. Accordingly, N also provided herein are methods for enhancing the immune response of an antigen of interest in a subject, comprising administering h to the subject an antigen of interest with a lipidated imidazoquinoline compound described herein in an immunogenic composition, or administering to the subject a composition comprising a lipidated imidazoquinoline compound described herein in combination with N (e.g., prior to, concurrently, or subsequently) the administration of an immunogenic composition comprising an antigen of interest to the subject.

Abstract: An integrated photonic device for wavelength division multiplexing comprises: a wavelength-splitting/combining component configured to be re-used for both splitting a single signal to be split, wherein the signal to be split comprises plural wavelengths, to plural split signals, wherein each of the plural split signals is related to a unique wavelength band, and combining plural signals to be combined, wherein each of the plural signals to be combined is related to a unique wavelength band, to a single combined signal, wherein the wavelength-splitting/combining component comprises at least one output channel for providing an output signal and at least one response channel for receiving a response input signal from a light interaction induced by the output signal, wherein the output channel and the response channel are connected to different ports of the wavelength-splitting/combining component.

Abstract: A computer-implemented system for obtaining therapeutic rehabilitation guidelines for a patient suffering from aphasia includes an input means for receiving evoked event-related potential data obtained through electroencephalography of a patient. The evoked event-related potential data is evoked by providing at least one predetermined language paradigm to the patient and the evoked event-related potential data includes amplitude, latency and source information for the evoked event-related potentials. The system also has a processor for processing the evoked event-related potential data including evaluating whether one or more of an amplitude, latency or source are within normative values for the at least one predetermined language paradigm and deriving based thereon a therapy to be applied to the patient, and an output for outputting the therapy instructions to be applied to the patient suffering from aphasia.

Abstract: The present invention relates to polyoxazoline polymers, polymer combinations and compositions comprising those polymers or combinations of polymers. The invention further relates to the use of said polyoxazoline polymers, said combinations and compositions comprising such polymers and combinations for the sustained release of one or more active ingredients, in particular one or more active pharmaceutical ingredients. It further relates to the use of polyoxazoline polymers or polymer combinations as drug carrier.