Abstract: The present invention relates to a nisin derivative comprising amino acid substitutions in the peptide sequence encoding the hinge region of the protein, wherein the derivative exhibits an increased anti-microbial activity.

Abstract: A sensor material of the type comprising a long-decay photoluminescent, protonable dye embedded in a suitable polymeric matrix, is used for generating a specific optical response to two different analytes present in a sample, thus allowing selective determination of the two analytes in the sample. Also described is a method for the simultaneous sensing of a first and second analyte in a sample. The method comprises the steps of irradiating a sensor material of the type comprising a long-decay photoluminescent protonable dye embedded in a suitable polymeric matrix with light of one or two wavelengths, determining photoluminescence intensity and lifetime signals originating from the sensor, and correlating the photoluminescence intensity signal with a concentration of the first analyte and the photoluminescence lifetime signal(s) with the concentration of the second analyte.

Abstract: The current inventions relates to a strain of Lactobacillus amylovorus designated FST 2.11 as deposited under the accession no DSM 19280 on 13 Apr. 2007 in the DSMZ depository, and strains substantially similar thereto also encoding anti-fungal and bread antistaling properties and applications thereof.

Abstract: One aspect of the invention is a homodyne coherent receiver, suitable for high speed phase shift keying (PSK), the receiver comprising a receiver for receiving an incoming signal having a carrier-less modulation format, a signal conditioning sub-system that generates a carrier component from the incoming signal, and an optical injection phase locked loop (OIPLL) that phase locks the generated carrier component of the incoming signal. Embodiments of the invention may enable DSP free detection of optical PSK signals, which may be required in next generation fiber transmission systems and in optical constellation analyzer systems. In addition, embodiments of the invention may provide improved receiver sensitivity performance comparing to prior art systems using direct detection schemes. Also, embodiments of the invention may be advantageous in terms of cost and energy efficiency.

Abstract: A method of assessing toxicity of a candidate agent to a sample of cells comprises the steps of providing a sample of cells, exposing the cells to the candidate agent for a suitable period of time, assaying the cells to measure data for at least one parameter of cellular function; and correlating the measured data of the at least one parameter of cellular function with toxicity, wherein the step of exposing the cells to the candidate agent is carried out in the presence of a reagent capable of facilitating transport of the candidate agent into the cell. The transport reagent may be an endocytosis, pinocytosis inducing agent, a peptide, or a liposome. The at least one parameter of cellular function may be selected from the group consisting of: cell viability; proliferation rate; membrane integrity; and a metabolic parameter.

Abstract: The use of a compound of general formula (I): or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment or prevention of a disease or condition characterised by apoptosis or degeneration of mammalian cells, wherein: R1 is a alkoxy, alkyl, ether or ester group; R2 is H or has the formula wherein Y is linear or branched, saturated or unsaturated, aliphatic group with from 2 to 23 carbon atoms, or a cyclic group, and which can contain substituents selected from the group consisting of hydroxyl, alkoxy, amino, carboxyl, cyano, nitro, alkylsuphonyl or halogen atoms, X is O or S; and R3 is any substituent.

Abstract: Described herein are isolated mammalian cells (progenitor cell biomarkers), referred to as primitive vascular progenitor cells (PVPC), which are present in and isolated from blood (e.g., peripheral blood) and useful as biomarkers of vascular remodeling in mammals (e.g., humans, rodents).

Abstract: The invention provides time-synchronised transmission of data on the (polarisation or phase-modulated) QKD channel and the (on-off modulated) conventional channel such that a QKD bit is only transmitted when a zero, or sequence of zeros, is transmitted on the conventional channel. Also, there is co-directional propagation of the QKD and conventional channel. Further, there is dispersion management through wavelength selection or control of fibre properties or other means such that the “walk-off in time of the QKD pulses and the Raman pulses generated by the ones on the conventional channel is less than or of the order of one bit period. The latter can be achieved, for example, by placing the conventional and QKD channel wavelengths close to the point where the group velocity-induced time delay for optical pulses propagating in the fibre reaches a minimum. This dispersion minimum occurs at a wavelength of 1.3 microns in standard fibre. The invention discloses a receiver embodiment to implement the invention.

Abstract: The invention is based on the surprising finding that treatment with a chemotherapeutic agent such as 5-fluorouracil (5-FU) and an autophagy inducer effectively inhibit the continued growth of, and prevent the recovery following drug withdrawal, of cancer cells. In vivo, drug resistance from a failure to adequately engage in apoptotic programmed cell death leads to a recurrence of cancer and tumours can remain dormant for periods of time before re-emerging as drug resistant metastases. It has been hypothesised that autophagy (Type II cell death) may help cancer cells survive in response to growth limiting conditions, such as nutrient depletion, hypoxia, absence of growth factor, or presence of cytotoxic drug. LiCl is a known autophagy inducer and accelerates cell survival to autophagic programmed cell death.

Abstract: A wireless network (1) comprises a base station (2) and sensor nodes (3). The base station (2) comprises a network interface (10), an application interface (11), topology control functions (12) a timer (13), and a buffer (14). Each sensor node (3) comprises a network interface (20), route control functions (21), processing functions (22), sensors (23), flood mechanism programs (24), tree mechanism programs (25), and data forwarding programs (26). The network operates by establishing a conventional routing tree from the sink node that is used when the network is stable. But when a sending node detects a node or link failure it dynamically switches to sending its data packets using a flooding mechanism, rather than waiting for the routing tree to be reestablished. This reduces the latency for data delivery. Also, when flooding the data packets, it allows the packets to be flooded to nodes that are an equal number of hops from the sink node as the send node is from the sink node.

Abstract: A laser device (1) comprises a ridge waveguide (2) comprising an upper cladding layer (5) and a lower cladding layer (6), between which is located an active layer (7). A ridge (8) formed in the upper cladding layer (5) defines the lateral width of a light guiding region (9) in the active layer (7). The ridge (8) is formed so that a portion (13) of the light guiding region (9) extends above the active layer (7) into the ridge (8). A plurality of lateral reflecting slots (15) extend laterally across the ridge (8) and extend into the ridge (8) to a depth sufficient to extend into the portion (13) of the light guiding region (9) which extends into the ridge (8) in order that the reflectivity of each lateral slot (15) is in the order of 2%.

Abstract: The current invention provides use of a CLA-producing bacterium for the in vivo conversion in the gut of polyunsaturated fatty acids to CLA. The CLA-producing bacterium is selected from one or more of the group consisting of propionibacteria, lactobacilli, lactococci and streptococci, and bifidobacteria.

Abstract: A junctionless metal-oxide-semiconductor transistor is described. In one aspect, a transistor device comprises a semiconductor material. The semiconductor material comprises first, second, and third portions. The second portion is located between the first and third portions. The first, second, and third portions are doped with dopants of the same polarity and the same concentration. The transistor device further comprises an electrode connected to the second portion. A current flows between the first and third portions when a voltage is applied to the electrode.

Abstract: An animation tool which is configured to enable a user to generate one or more animations for subsequent execution on a computer platform is described. The animation tool provides a plurality of graphical integers which a user can use to generate an animation. The graphical integers are divisible into graphical elements and graphical element effects, the effects being applied by a user onto an element and defining the viewing properties of that element.

Abstract: A method of wet etching produces high-precision microneedle arrays for use in medical applications. The method achieves precise process control over microneedle fabrication, at single wafer or batch-level, using wet etching of silicon with potassium hydroxide (KOH) solution by accurately identifying the etch time endpoint. Hence, microneedles of an exactly required height, shape, sharpness and surface quality are achieved. The outcome is a reliable, reproducible, robust and relatively inexpensive microneedle fabrication process. Microneedles formed by KOH wet etching have extremely smooth surfaces and exhibit superior mechanical and structural robustness to their dry etched counterparts. These properties afford extra reliability to such silicon microneedles, making them ideal for medical applications. The needles can also be hollowed. Wet etched silicon microneedles can then be employed as masters to replicate the improved surface and structural properties in other materials (such as polymers) by moulding.

Abstract: An array of highly efficient micro-LEDs where each micro-LED is an integrated diode structure in a mesa, in which the mesa shape and the light-emitting region are chosen for optimum efficiency. A single one of the micro-LEDs includes, on a substrate and a semiconductor layer, a mesa, a light emitting layer, and an electrical contact. The micro-LEDs in this device have a very high EE because of their shape. Light is generated within the mesa, which is shaped to enhance the escape probability of the light. Very high EEs are achieved, particularly with a near parabolic mesa that has a high aspect ratio. The top of the mesa is truncated above the light-emitted layer (LEL), providing a flat surface for the electronic contact on the top of the semiconductor mesa. It has been found that the efficiency is high, provided the top contact has a good reflectivity value. Also, it has been found that efficiency is particularly high if the contact occupies an area of less than 16% of the truncated top mesa surface area.

Abstract: A strain of Bifidobacterium isolated from resected and washed human gastrointestinal tract is significantly immunomodulatory following oral consumption in humans. The strain is useful in the prophylaxis and/or treatment of undesirable inflammatory activity, especially gastrointestinal inflammatory activity such as inflammatory bowel disease or irritable bowel syndrome. The inflammatory activity may also be due to cancer.

Abstract: An initial epitaxial layer of GaN is grown on a sapphire substrate. The epitaxial layer is then etched in a reactive ion etch (RIE) chamber. This etching acts preferentially at defects, causing them to become enlarged cavities. The cavities are too large in proportion to the crystal lattice to act as defects in the usual sense, and so a further GaN epitaxial layer fills into the cavities. Thus, propagation of defects is avoided.

Abstract: The invention provides a method of manufacturing an avalanche diode comprising the steps of applying a mask (6) over an active diode region (5) in a wafer (1), and damaging the region the surrounding the active diode region by breaking bonds in the semiconductor lattice to provide gettering sites in this surrounding region.

Abstract: An insulating layer (5) and a conductive seed layer (6) are applied to a substrate (1) in a simple process. A photo resist with palladium chloride are provided in a bath for electrophoretic deposition onto the substrate. The photo resist is an insulator and the palladium chloride is a catalyst. The layer is heated with UV to cure it. The layer is plasma etched to expose more of the palladium chloride, which acts as a catalyst for electrodes plating of the conductive seed layer. A thicker conductive layer (7) is then electroplated onto the seed layer. These steps may be repeated for successive insulating and/or conductive layers.