Patents Assigned to University Court of the University of Dundee
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Publication number: 20130131102Abstract: The present invention provides glucoimidazole derivatives and methods of making them. The compounds can be used to inhibit the activity of O-GlcNAcase enzymes, including both bacterial OGA (bOGA) and human OGA (hOGA) and can be selective, showing low inhibition of hexosaminidases. The compounds can be used to study the role of the O-GlcNAcase modification in human or animal cells. Furthermore the compounds can have therapeutic uses in the treatment of diseases mediated by the activity of O-GlcNAcase enzymes including type II diabetes, Alzheimers Disease, and cancer.Type: ApplicationFiled: November 13, 2012Publication date: May 23, 2013Applicant: The University Court of the University of DundeeInventor: The University Court of the University of Dundee
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Patent number: 8394382Abstract: The present invention relates to agents capable of binding sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) and their use in the treatment of cell proliferation and differentiation disorders. Furthermore, the present invention provides associated pharmaceutical formulations and methods.Type: GrantFiled: September 16, 2010Date of Patent: March 12, 2013Assignee: University Court of the University of DundeeInventors: Paul Richard Crocker, Bjoern Biedermann, David Bowen
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Patent number: 8338386Abstract: The present invention relates to the prevention/treatment of ichthyosis vulgaris (IV), atopy and potentially other disorders associated with loss-of-function mutations in the filaggrin gene sequence. The prevention/therapy is based on the use of agents which enable the host's translational machinery to read through a nonsense mutation found in a mutant allele of the filaggrin gene.Type: GrantFiled: January 17, 2007Date of Patent: December 25, 2012Assignee: University Court of the University of DundeeInventors: William Henry Irwin McLean, Frances Jane Dorothy Smith
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Publication number: 20120302748Abstract: The disclosure relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450 1B1 (CYP1B1) and allelic variants thereof. Also provided are pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. Provided are methods for identifying novel compounds for use in the treatment of prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express CYP1B1 and allelic variants thereof. Finally, provided is a method for determining the efficacy of a compound as described herein in treating cancer.Type: ApplicationFiled: February 28, 2012Publication date: November 29, 2012Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: Steven Albert Everett, Saraj Ulhaq
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Patent number: 8247064Abstract: This invention relates to coating a surface wherein the coated surface inhibits foulants such as cell and/or protein and/or prion adhesion or formation. In particular, the coated surface may be part of a medical device which inhibits bacterial adhesion and colonisation, thrombus formation and/or prion, blood protein and/or protein formation.Type: GrantFiled: July 10, 2003Date of Patent: August 21, 2012Assignee: The University Court of the University of DundeeInventors: Qi Zhao, Eric Abel
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Publication number: 20120190639Abstract: The invention relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450 1B1 (CYP1B1) and allelic variants thereof. The invention also provides pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. The invention also provides methods for identifying novel compounds for use in the treatment of prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express CYP1 B1 and allelic variants thereof. The invention also provides a method for determining the efficacy of a compound of the invention in treating cancer.Type: ApplicationFiled: April 30, 2010Publication date: July 26, 2012Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: Steven Albert Everett, Saraj Ulhaq
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Patent number: 8207175Abstract: The present invention relates to compounds and uses of compounds which interact with chitinase enzymes, in particular the inhibition of those enzymes.Type: GrantFiled: June 21, 2006Date of Patent: June 26, 2012Assignee: University Court of the University of DundeeInventors: Daniel Marinus Ferdinand Van Aalten, Ian Michael Eggleston
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Publication number: 20120082684Abstract: The present invention provides methods for diagnosing cell proliferation and/or differentiation disorders, compounds and methods for treating the same and methods for identifying agents potentially useful in the treatment of cell proliferation and/or differentiation disorders.Type: ApplicationFiled: March 15, 2010Publication date: April 5, 2012Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: Sonia Rocha, Angus Iain Lamond, Motoharu Ono, Kayo Yamada
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Publication number: 20110104149Abstract: The present invention relates to agents capable of binding sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) and their use in the treatment of cell proliferation and differentiation disorders. Furthermore, the present invention provides associated pharmaceutical formulations and methods.Type: ApplicationFiled: September 16, 2010Publication date: May 5, 2011Applicant: University Court of the University of DundeeInventors: Paul Richard Crocker, Bjoern Biedermann, David Bowen
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Publication number: 20110027385Abstract: A process for the production of an aqueous dispersion of metal nano particles comprising palladium is provided. The process comprises the admixture of a water soluble organic polymer, a palladium salt and a first reducing agent to an aqueous liquid. The first reducing agent is a metal-containing polymer which has reducing properties or a saccharide which has reducing properties. The nano particles can include a second metal. The dispersions can be used as catalysts for electroless plating, to produce heterogeneous catalysts and in the production of anti-microbial devices and compositions.Type: ApplicationFiled: November 21, 2008Publication date: February 3, 2011Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: James Anthony Cairns, Graham James Berry, Roderick Allan George Gibson
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Publication number: 20110021529Abstract: The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions (involving sirtuin function).Type: ApplicationFiled: September 4, 2007Publication date: January 27, 2011Applicants: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE, UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWSInventors: Sonia Lain, David Phillip Lane, Michael John Raymond Stark, Anna Rose McCarthy, Jonathan James Hollick, Nicholas James Westwood
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Publication number: 20100305070Abstract: The disclosure relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450 1B1 (CYP1B1) and allelic variants thereof. Also provided are pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. Provided are methods for identifying novel compounds for use in the treatment of prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express CYP1B1 and allelic variants thereof. Finally, provided is a method for determining the efficacy of a compound as described herein in treating cancer.Type: ApplicationFiled: April 30, 2010Publication date: December 2, 2010Applicant: The University Court of the University of DundeeInventors: Steven Albert Everett, Saraj Ulhaq
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Publication number: 20100210578Abstract: The present invention relates to the prevention/treatment of ichthyosis vulgaris (IV), atopy and potentially other disorders associated with loss-of-function mutations in the filaggrin gene sequence. The prevention/therapy is based on the use of agents which enable the host's translational machinery to read through a nonsense mutation found in a mutant allele of the filaggrin gene.Type: ApplicationFiled: January 17, 2007Publication date: August 19, 2010Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: William Henry Irwin McLean, Frances Jan Dorothy Smith
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Publication number: 20100017896Abstract: The present invention relates to the identification of loss-of-function mutations in the filaggrin gene and their use in diagnosing ichthyosis vulgaris and/or susceptibility to other diseases including atopic dermatitis (eczema), asthma, psoriasis and allergies (including food allergy).Type: ApplicationFiled: December 15, 2006Publication date: January 21, 2010Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: William Henry Irwin McLean, Frances Jane Dorothy Smith
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Patent number: 7592191Abstract: A field emission backplate formed by laser crystallizing of an area of amorphous semiconductor based material. Emitter sites result from the rough surface texture caused by the crystallization process. The crystallization may be localized using laser interferometry, and profiled emitter tips grown on the localized crystalline areas. Such backplates can be used in field emission devices emitting into either a vacuum or a wide band gap light-emitting polymer. Furthermore, a backplate having self-aligned gates can be formed by depositing an insulator layer and a metal layer over the emitter tips, removing the top of the metal layer and etching away the insulator, leaving each tip surrounded by a metal rim. A planarizing agent can be used to refine this process.Type: GrantFiled: February 6, 2004Date of Patent: September 22, 2009Assignee: The University Court of the University of DundeeInventors: Mervyn John Rose, Ravi Silva, John Shannon
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Publication number: 20090215798Abstract: The present invention relates to compounds and uses of compounds which interact with chitinase enzymes, in particular inhibition of those enzymes.Type: ApplicationFiled: June 21, 2006Publication date: August 27, 2009Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: Danile Marinus Ferdinand Van Aalten, Ian Michael Eggleston
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Publication number: 20090036464Abstract: This invention relates to a method of testing agents, such as sigma ligands for their potential use in treating posterior capsule opacification (PCO). The present invention also relates to the use of sigma ligands, such as sigma-1 antagonists in the manufacture of a medicament for preventing posterior capsule opacification (PCO), as well as methods of treating PCO using sigma ligands.Type: ApplicationFiled: August 26, 2005Publication date: February 5, 2009Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: Barbara Ann Spruce, George Duncan, Peter Reid Duncan, Alan Prescott
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Publication number: 20090010888Abstract: The invention provides a method of enhancing the effectiveness of pesticides, as well as pesticidal formulations. Furthermore, it also provides the means for the de novo rational design of pesticides. The present invention also relates to a method of screening agents for potential use in insecticides, particularly against mosquitoes.Type: ApplicationFiled: June 22, 2007Publication date: January 8, 2009Applicants: University Court of the University of Dundee, The University of LiverpoolInventors: Mark John Ingraham Paine, Charles Roland Wolf, Lesley Ann McLauchlin
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Patent number: 7304420Abstract: A field emission device having improved properties and which finds use in display devices, such as a flat panel displays. Known devices and displays suffer from problems such as complexity of fabrication and limited color gamut. The present device provides a field emission backplate which is made from a substantially semiconductor based material and has a plurality of grown tips. The device also includes at least one electro-luminescent or photo-luminescent material having a fluorescent material such as a fluorescent dye doped material chemically attached thereto.Type: GrantFiled: December 17, 2004Date of Patent: December 4, 2007Assignee: The University Court of the University of DundeeInventors: Mervyn John Rose, Ravi Silva, John Shannon, Janos Peter Hajto
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Publication number: 20070166712Abstract: This invention relates to a retinoic acid metabolizing cytochrome P450 2S1 (CYP2S1) and to uses of sequence specific nucleic acid, primers and antibodies, in, for example, assays for the analysis of CYP2S1 messenger RNA and/or protein expression in skin. The invention also relates to assays for detecting agents which modulate CYP2S1 expression and/or activity and methods of testing drug efficacy.Type: ApplicationFiled: April 5, 2004Publication date: July 19, 2007Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEEInventors: Gillian Smith, Sally Ibbotson, Charles Wolf