Abstract: Indole compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, schemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.
Type:
Application
Filed:
August 5, 2020
Publication date:
September 22, 2022
Applicants:
NEW YORK UNIVERSITY, UNIVERSITY OF ALBANY
Inventors:
Ann Marie SCHMIDT, Ravichandran RAMASAMY, Alexander SHEKHTMAN, Vivek RAI, Michaele B. MANIGRASSO
Abstract: The present disclosure identifies compounds that bind to a t-RNA-dependent riboswitch of aaRS gene expression unique to Gram-positive bacteria. The compounds have anti-bacterial activity.
Type:
Grant
Filed:
July 23, 2014
Date of Patent:
April 23, 2019
Assignee:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF ALBANY